Biomonitoring of workers exposed to aromatic amines in rubber vulcanization

Pavan, I; Belliardo, Flavio; Buglione, E.; Massiccio, M. M.

doi:10.1007/bf02688561

Cited by 3 publications

References 1 publication

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N‐Isopropyl‐N′‐phenyl‐p‐phenylendiamin (IPPD) [MAK Value Documentation in German language, 2013]

2013

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 55. Lieferung, Ausgabe 2013 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme, Verteilung, Ausscheidung Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Bewertung

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N‐Isopropyl‐N′‐phenyl‐p‐phenylendiamin (IPPD) [MAK Value Documentation in German language, 2013]

2013

The MAK‐Collection for Occupational Health and Safety

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N‐Isopropyl‐N′‐phenyl‐p‐phenylenediamine [MAK Value Documentation, 2013]

Hartwig

2016

The MAK‐Collection for Occupational Health and Safety

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The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated the maximum concentration at the workplace (MAK value) of N‐ Isopropyl‐ N′ ‐phenyl‐ p‐ phenylenediamine, considering all toxicity endpoints. Available unpublished study reports and publications are described in detail. Critical effects of N‐ Isopropyl‐ N′ ‐;?>phenyl‐ p‐ phenylenediamine are increased liver weights, changes in haematological parameters indicating anaemia and its skin‐sensitizing property. In oral studies no NOAEL was obtained, therefore a read‐across to the structurally analogous N‐ (1,3‐dimethylbutyl)‐ N′‐ phenyl ‐p‐ phenylenediamine is used. The chronic NOAEL for N‐ (1,3‐dimethylbutyl)‐ N′‐ phenyl ‐p‐ phenylenediamine in male rats is 2.6 mg/kg body weight based on effects on the liver which can be used to calculate a MAK value of 2 mg/m 3 for the inhalable fraction. This value also provides protection from irritation. As the critical effect is systemic, Peak Limitation Category II is assigned. The default excursion factor of 2 is set as no half‐life in blood is known. Damage to the embryo is unlikely if the MAK value for N‐ Isopropyl‐ N′ ‐phenyl‐ p‐ phenylenediamine is observed and the substance is classified in Pregnancy Risk Group C. N‐ Isopropyl‐ N′ ‐phenyl‐ p‐ phenylenediamine is a skin sensitizer and the designation with “Sh” is confirmed. There are no data concerning the potential for respiratory sensitization. Skin contact is not expected to contribute significantly to systemic toxicity. N‐ Isopropyl‐ N′ ‐phenyl‐ p‐ phenylenediamine is regarded as not being genotoxic or carcinogenic like its analog N‐ (1,3‐dimethylbutyl)‐ N′‐ phenyl ‐p‐ phenylenediamine.

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