Bionanocomposites based on cationic and anionic layered clays as controlled release devices of amoxicillin

Rebitski, Ediana P.; Souza, Gabriel Pinto de; Santana, Sirlane Aparecida Abreu; Pergher, Sibele Berenice Castellã; Alcántara, Ana C. S.

doi:10.1016/j.clay.2019.02.024

Cited by 51 publications

(15 citation statements)

References 54 publications

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“…[1][2][3][4][5][6] Of particular relevance are those systems in which the inorganic component is a silicate belonging to the family of clay minerals, giving rise to nanocomposite materials involving porous and layered silicates. [7][8][9][10][11][12] The resulting materials may exhibit markedly improved mechanical, thermal, optical, and physicochemical properties compared to those of the pure polymer or conventional (microscale) composites, 13 as first demonstrated by Fukushima and co-workers for nylon-clay nanocomposites. 14 In recent years, nanocellulose based materials have been the focus of active research with the aim of developing a wide variety of hybrid materials for applications in adaptive and responsive materials, energy storage and conversion, water treatment, biomedicine, packaging, fire retardancy, as a support for metal and metal oxide nanoparticles in catalysts, and electronics.…”

Section: Introductionmentioning

confidence: 99%

Functional biohybrid materials based on halloysite, sepiolite and cellulose nanofibers for health applications

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Functional biohybrid materials based on halloysite, sepiolite and cellulose nanofibers for health applications

et al. 2020

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“…In recent years, hybrid nanomaterials composed by biopolymers and inorganic nanoparticles have attracted growing interest within several fields, including biomedicine [ 1 , 2 , 3 , 4 , 5 ], pharmaceutics [ 6 , 7 , 8 , 9 , 10 ], food packaging [ 11 , 12 , 13 , 14 , 15 ], remediation [ 16 , 17 ] and cultural heritage [ 18 , 19 , 20 ]. As evidenced in a recent review [ 21 ], both ionic and non-ionic polysaccharides can be suitable polymers for the development of functional nanocomposites, with excellent performances in terms of thermal stability, barrier properties and mechanical behavior.…”

Section: Introductionmentioning

confidence: 99%

Halloysite Nanotubes Coated by Chitosan for the Controlled Release of Khellin

2020

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In this work, we have developed a novel strategy to prepare hybrid nanostructures with controlled release properties towards khellin by exploiting the electrostatic interactions between chitosan and halloysite nanotubes (HNT). Firstly, khellin was loaded into the HNT lumen by the vacuum-assisted procedure. The drug confinement within the halloysite cavity has been proved by water contact angle experiments on the HNT/khellin tablets. Therefore, the loaded nanotubes were coated with chitosan as a consequence of the attractions between the cationic biopolymer and the halloysite outer surface, which is negatively charged in a wide pH range. The effect of the ionic strength of the aqueous medium on the coating efficiency of the clay nanotubes was investigated. The surface charge properties of HNT/khellin and chitosan/HNT/khellin nanomaterials were determined by ζ potential experiments, while their morphology was explored through Scanning Electron Microscopy (SEM). Water contact angle experiments were conducted to explore the influence of the chitosan coating on the hydrophilic/hydrophobic character of halloysite external surface. Thermogravimetry (TG) experiments were conducted to study the thermal behavior of the composite nanomaterials. The amounts of loaded khellin and coated chitosan in the hybrid nanostructures were estimated by a quantitative analysis of the TG curves. The release kinetics of khellin were studied in aqueous solvents at different pH conditions (acidic, neutral and basic) and the obtained data were analyzed by the Korsmeyer–Peppas model. The release properties were interpreted on the basis of the TG and ζ potential results. In conclusion, this study demonstrates that halloysite nanotubes wrapped by chitosan layers can be effective as drug delivery systems.

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“…17,18 More recently, biopolymers are considered perspective candidates as they have been defined ''intrinsically reversible'' because they are expected to vanish from the stone surface once their action has ceased or to produce nonaggressive residues, and they do not create any issues in subsequent conservation treatments. [19][20][21][22] Actually, biopolymers are widely used in restoration protocols as thickening agents for cleaning formulations and, to some extent, they have been introduced as coatings against sulphation or to enhance water repellency. [23][24][25][26][27][28][29] Their combination with nanoparticles is a promising strategy to further improve the physicochemical properties.…”

Section: Introductionmentioning

confidence: 99%

Halloysite nanotubes-based nanocomposites for the hydrophobization of hydraulic mortar

et al. 2021

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The treatment of stone surfaces for their protection from ageing caused by natural and anthropogenic effects is an open issue in materials development for Cultural Heritage. We thought interesting to verify the suitability of a modified cellulose biofilm filled with halloysite nanotubes as wax compatibilizers to design a protecting layer. A hydraulic mortar was selected as a stone prototype. To improve the physico-chemical properties of the covering layer, wax microparticles have been incorporated to control transport, consolidation and wettability features. In particular, different application protocols have been studied, namely brushing and spraying, to assess whether the proposed procedures can be scaled up. Colorimetric analysis has been carried out to evidence the applicability in terms of color alteration after the treatment. Water adhesion was investigated by measuring the contact angle values as a function of time to obtain information on spreading and adsorption phenomena. These physico-chemical properties have been correlated to the microstructure evidenced by both electron and optical microscopies. Graphic abstract

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Bionanocomposites based on cationic and anionic layered clays as controlled release devices of amoxicillin

Cited by 51 publications

References 54 publications

Functional biohybrid materials based on halloysite, sepiolite and cellulose nanofibers for health applications

Functional biohybrid materials based on halloysite, sepiolite and cellulose nanofibers for health applications

Halloysite Nanotubes Coated by Chitosan for the Controlled Release of Khellin

Halloysite nanotubes-based nanocomposites for the hydrophobization of hydraulic mortar

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