Bionic manufacturing strategy of hydroxyapatite-coated polyether ether ketone scaffolds for promoting mineralization and osseointegration

Yakufu, Maihemuti; Wang, Zongliang; Liu, Jianguo; Zhang, Peibiao

doi:10.1016/j.matdes.2022.111193

Cited by 11 publications

(3 citation statements)

References 58 publications

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“…[ 40,41 ] Nevertheless, the addition of HA into the PXDD led to a lower surface roughness of PXDD140/HA‐Fe scaffolds as shown in the AFM results in Figure 3D, in comparison to that of PXDD140‐Fe scaffolds. Despite some studies that reported the less favorable cell attachment on a smoother surface, the bioactive surface of HA that can promote osteointegration with bone tissue [ 42 ] could surpass the declining effect.…”

Section: Resultsmentioning

confidence: 99%

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Evaluation of in vitro corrosion behavior and biocompatibility of poly[xylitol‐(1,12‐dodecanedioate)](PXDD)‐HA coated porous iron for bone scaffolds applications

Md Yusop,

Wan Ali,

Jamaludin

et al. 2024

Biotechnology Journal

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The present study evaluates the corrosion behavior of poly[xylitol‐(1,12‐dodecanedioate)](PXDD)‐HA coated porous iron (PXDD140/HA‐Fe) and its cell‐material interaction aimed for temporary bone scaffold applications. The physicochemical analyses show that the addition of 20 wt.% HA into the PXDD polymers leads to a higher crystallinity and lower surface roughness. The corrosion assessments of the PXDD140/HA‐Fe evaluated by electrochemical methods and surface chemistry analysis indicate that HA decelerates Fe corrosion due to a lower hydrolysis rate following lower PXDD content and being more crystalline. The cell viability and cell death mode evaluations of the PXDD140/HA‐Fe exhibit favorable biocompatibility as compared to bare Fe and PXDD‐Fe scaffolds owing to HA's bioactive properties. Thus, the PXDD140/HA‐Fe scaffolds possess the potential to be used as a biodegradable bone implant.

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Section: Resultsmentioning

confidence: 99%

“…Despite some studies that reported the less favorable cell attachment on a smoother surface, the bioactive surface of HA that can promote osteointegration with bone tissue [42] could surpass the declining effect.…”

Section: Cell Death Mode In Hfob Cellsmentioning

confidence: 88%

Evaluation of in vitro corrosion behavior and biocompatibility of poly[xylitol‐(1,12‐dodecanedioate)](PXDD)‐HA coated porous iron for bone scaffolds applications

Md Yusop,

Wan Ali,

Jamaludin

et al. 2024

Biotechnology Journal

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“…In order to improve PEEK’s bioactivity, scholars have explored a variety of modification methods and often employed the deposition of bone-like apatite in simulated body fluids (SBF) to evaluate bioactivity improvements . One of the popular methods is to simply produce a bioactive coating onto the surfaces, such as bioglass, hydroxyapatite, calcium phosphate, or calcium silicate, − through which the bioactivity can be indeed improved. However, there are several drawbacks to the coatings, such as poor adherence to the substrate surface, which results in a lack of bioactivity even when the substrate is exposed and usually causes subsequent osteolysis and implant loosening. , Sulfonation of PEEK with sulfuric acid is another commonly used modification strategy.…”

Section: Introductionmentioning

confidence: 99%

Efficient Osteogenic Activity of PEEK Surfaces Achieved by Femtosecond Laser–Hydroxylation

Luo

Huang

et al. 2023

ACS Appl. Mater. Interfaces

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Poly(etheretherketone) (PEEK) is regarded as an attractive orthopedic material because of its good biocompatibility and mechanical properties similar to natural bone. The efficient activation methods for the surfaces of PEEK matrix materials have become a hot research topic. In this study, a method using a femtosecond laser (FSL) followed by hydroxylation was developed to achieve efficient bioactivity. It produces microstructures, amorphous carbon, and grafted −OH groups on the PEEK surface to enhance hydrophilicity and surface energy. Both experimental and simulation results show that our modification leads to a superior ability to induce apatite deposition on the PEEK surface. The results also demonstrate that efficient grafting of C–OH through FSL–hydroxylation can effectively enhance cell proliferation and osteogenic differentiation compared to other modifications, thus improving osteogenic activity. Overall, FSL hydroxylation treatment is proved to be a simple, efficient, and environmentally friendly modification method for PEEK activation. It could expand the applications of PEEK in orthopedics, as well as promote the surface modification and structural design of other polymeric biomaterials to enhance bioactivity.

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Recent developments in functional organic polymer coatings for biomedical applications in implanted devices

Yang,

Jia,

Zhao

et al. 2024

Friction

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Organic polymer coatings have been commonly used in biomedical field, which play an important role in achieving biological antifouling, drug delivery, and bacteriostasis. With the continuous development of polymer science, organic polymer coatings can be designed with complex and advanced functions, which is conducive to the construction of biomedical materials with different performances. According to different physical and chemical properties of materials, biomedical organic polymer coating materials are classified into zwitterionic polymers, non-ionic polymers, and biomacromolecules. The strategies of combining coatings with substrates include physical adsorption, chemical grafting, and self-adhesion. Though the coating materials and construction methods are different, many biomedical polymer coatings have been developed to achieve excellent performances, i.e., enhanced lubrication, anti-inflammation, antifouling, antibacterial, drug release, anti-encrustation, anti-thrombosis, etc. Consequently, a large number of biomedical polymer coatings have been used in artificial lungs, ureteral stent, vascular flow diverter, and artificial joints. In this review, we summarize different types, properties, construction methods, biological functions, and clinical applications of biomedical organic polymer coatings, and prospect future direction for development of organic polymer coatings in biomedical field. It is anticipated that this review can be useful for the design and synthesis of functional organic polymer coatings with various biomedical purposes.

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Bionic manufacturing strategy of hydroxyapatite-coated polyether ether ketone scaffolds for promoting mineralization and osseointegration

Cited by 11 publications

References 58 publications

Evaluation of in vitro corrosion behavior and biocompatibility of poly[xylitol‐(1,12‐dodecanedioate)](PXDD)‐HA coated porous iron for bone scaffolds applications

Evaluation of in vitro corrosion behavior and biocompatibility of poly[xylitol‐(1,12‐dodecanedioate)](PXDD)‐HA coated porous iron for bone scaffolds applications

Efficient Osteogenic Activity of PEEK Surfaces Achieved by Femtosecond Laser–Hydroxylation

Recent developments in functional organic polymer coatings for biomedical applications in implanted devices

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