1989
DOI: 10.1007/978-1-4684-0324-4
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Bioorganic Chemistry

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Cited by 58 publications
(11 citation statements)
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References 347 publications
(434 reference statements)
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“…The base-catalyzed hydrolysis of RNA proceeds through the formation of a strained five-membered cyclic phosphate that results from nucleophilic attack of the vicinal hydroxyl group . The resistance of 24a to base-catalyzed hydrolysis is similar to that observed for deoxyribonucleotide oligomers and is consistent with the fact that the hydroxyl function on the proximal 2‘-ethyl side chain is unable to assist hydrolysis …”
Section: Resultssupporting
confidence: 55%
“…The base-catalyzed hydrolysis of RNA proceeds through the formation of a strained five-membered cyclic phosphate that results from nucleophilic attack of the vicinal hydroxyl group . The resistance of 24a to base-catalyzed hydrolysis is similar to that observed for deoxyribonucleotide oligomers and is consistent with the fact that the hydroxyl function on the proximal 2‘-ethyl side chain is unable to assist hydrolysis …”
Section: Resultssupporting
confidence: 55%
“…[27,28] Analogously to the interactions that are abundant in many reaction centers of enzymes between the amino acid side chains and the metal centers, the interaction between organic ligands and the surface of an inorganic nanoparticle paves the way for the coupling of biomolecular recognition systems to generate novel materials. For instance, bioorganic model systems have long been elaborated to provide tools for probing the mechanisms of biological principles, as well as to develop chemical means for the handling and manipulating biological components.…”
Section: Coupling Of Nanoparticles and Biomoleculesmentioning
confidence: 99%
“…The design and synthesis of molecules having catalytic activity and substrate specificity, mimicking natural enzymes, have been a long-standing goal of chemists (1). RNA has become an interesting target for artificial hydrolytic enzymes during the last few years, partly because of possible therapeutic applications.…”
mentioning
confidence: 99%