1990
DOI: 10.1002/jps.2600790715
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Biopharmaceutical evaluation of ketoprofen following intravenous, oral, and rectal administration in dogs

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1991
1991
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Cited by 25 publications
(17 citation statements)
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“…The short half-life of ketoprofen in Japanese quail may have been due to rapid metabolism and excretion of the drug since birds have a higher metabolic rate when compared to mammals of similar body size (Dorrestein, 1992). The 24% bioavailability of ketoprofen after oral administration to Japanese quail in this study was low compared to humans (approximately 90%; Jamali & Brocks, 1990) and rats and dogs (approximately 100%; Julou et al, 1983;Schmitt & Guentert, 1990). In horses, oral bioavailability varied according to drug formulation and food availability, where bioavailability was 0% with an oil-based paste with unrestricted food access and was 5% with the same oil-based paste with restricted food access (Landoni & Lees, 1995b).…”
contrasting
confidence: 49%
See 1 more Smart Citation
“…The short half-life of ketoprofen in Japanese quail may have been due to rapid metabolism and excretion of the drug since birds have a higher metabolic rate when compared to mammals of similar body size (Dorrestein, 1992). The 24% bioavailability of ketoprofen after oral administration to Japanese quail in this study was low compared to humans (approximately 90%; Jamali & Brocks, 1990) and rats and dogs (approximately 100%; Julou et al, 1983;Schmitt & Guentert, 1990). In horses, oral bioavailability varied according to drug formulation and food availability, where bioavailability was 0% with an oil-based paste with unrestricted food access and was 5% with the same oil-based paste with restricted food access (Landoni & Lees, 1995b).…”
contrasting
confidence: 49%
“…The range of half-lives among mammals is 1.5-19 h (Kantor, 1986;Foster & Jamali, 1988;Schmitt & Guentert, 1990;Landoni & Lees, 1995a). The short half-life of ketoprofen in Japanese quail may have been due to rapid metabolism and excretion of the drug since birds have a higher metabolic rate when compared to mammals of similar body size (Dorrestein, 1992).…”
mentioning
confidence: 96%
“…These values were not significantly merent (P = 0.05: Friedman test). Bioavailability values of ketoprofen in mares after rectal administration of 1 g ketoprofen in the different rectal formulations are shown in (Schmitt & Guentert, 1990). the absolute bioavailability of ketoprofen in horses after rectal administration of the three formulations was relatively low, with a large interindividual variability (24.5 +9.5%, 28.7+ 18% and 31.356.8% for the fatty suppository, the hydrophilic suppository and the liquid suspension respectively).…”
Section: Resultsmentioning
confidence: 99%
“…1988). horses (Jassaud et al, 1993: Landoni & Lees, 1995 and dogs (Schmitt & Guentert 1990) have been documented. Little is known about the rectal administration of drugs to horses.…”
Section: Introductionmentioning
confidence: 99%
“…In humans ketoprofen acid is usually given orally and is rapidly and almost completely absorbed (bioavailability about 92%, as reported by Jamali and Brocks (7). Its oral bioavailability is also high in dogs (90%) (17), but in horses with restricted access to food, Landoni and Lees (10) showed that after oral administration only 51% and 54% of R(-) and S(+) ketoprofen are absorbed, respectively. This is consistent with the digestion processes in the horse in which most digesta remain in the stomach briefly and spend most of the time in the large intestine (4), and the fact that the range in the gut (near 6 in stomach for two hours after a meal, 6 in the duodenum, 7-7.4 in the ileum, and 6 in the large intestine)(18) is unfavourable for ketoprofen absorption (plc 5.02 and octanolbuffer partition coefficient at pH 7.4 approximately 1) (13).…”
Section: Introductionmentioning
confidence: 99%