Biophysical and biochemical roles of Moringa oleifera leaves as radioprotector

Elwan, Azhar M.; Salama, Ahmed; Sayed, A. M.; Ghoneim, Ahmed; Elsaied, Aziza A.; Ibrahim, Fatma; Elnasharty, Mohamed M. M.

doi:10.1016/j.pbiomolbio.2018.06.003

Cited by 12 publications

(4 citation statements)

References 41 publications

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“…Boonanantanasarn et al [ 56 ] discovered that MO leaf extract stimulated osteogenic differentiation and mineralization in human PDL cells, showing its potential for tissue regeneration. Elwan et al reported the radioprotective characteristics of MO leaf extract, which improved bone marrow electrical properties and blood antioxidant levels [ 57 ]. Burali et al also mentioned the ability of MO leaf extract to prevent bone loss, implying that it could help mitigate the effects of radiation therapy on the PDL, cementum, and bone [ 58 , 59 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

The effectiveness of Moringa oleifera in the preservation of periodontium after radiation therapy: An experimental animal study

Bakr,

Balbola,

Gawad Mohamed

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

The effectiveness of Moringa oleifera in the preservation of periodontium after radiation therapy: An experimental animal study

Bakr,

Balbola,

Gawad Mohamed

et al. 2024

Heliyon

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“…A limited number of reports have suggested the role of Moringa oleifera leaf ethanolic extract (MLEE) as a radioprotective agent. MLEE shielded gamma-irradiated rats from redox imbalances, resulting in decreased relaxation time and increased electrical conductivity in bone marrow 15 . Furthermore, MLEE prevented lipid peroxidation and nuclear translocation of nuclear factor kappa B while restoring reduced glutathione levels in the livers of mice exposed to gamma radiation 16 , 17 .…”

Section: Introductionmentioning

confidence: 99%

Protective effect of Moringa oleifera leaf ethanolic extract against uranyl acetate-induced testicular dysfunction in rats

Ragab,

Almohaimeed,

Alghriany

et al. 2024

Sci Rep

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Uranyl acetate (UA) is used in civilian and military applications, predisposing it to wide dispersion in ecosystems. Using high-performance liquid chromatography, gas chromatography–mass spectrometry, and 2,2-Diphenyl-1-picrylhydrazyl scavenging radical analysis, we confirmed that Moringa oleifera leaf ethanolic extract (MLEE) is rich in biologically active phytochemicals. Thus, this study aims to investigate the possible defensive effect of MLEE against UA-induced testicular dysfunction. To achieve this, rats were divided randomly and evenly into three groups for 14 days. The control group received no treatment, while the UA group received a single intraperitoneal injection of UA at a dose of 5 mg/kg BW dissolved in saline on the 12th day of the experiment, followed by no treatment the following day. The MLEE + UA group received daily oral administration of MLEE (300 mg/kg BW) dissolved in distilled water before exposure to UA intoxication. The disruption observed in the pituitary–gonadal axis of UA-intoxicated rats was characterized by a significant decrease in luteinizing hormone, follicle-stimulating hormone, testosterone, and estradiol 17beta levels. Additionally, there was a notable increase in malondialdehyde and a decrease in catalase, superoxide dismutase, reduced glutathione, and nitric oxide, accompanied by an up-regulation in the immuno-expression of nuclear factor-kappa B, indicating a disturbance in the redox balance. The TUNEL assay confirmed a substantial rise in apoptotic cell numbers in the UA group. Testicular histopathological changes, excessive collagen deposition, and reduced glycogen content were evident following UA exposure. However, supplementation with MLEE effectively countered these mentioned abnormalities. MLEE is proposed to combat the toxicological molecular targets in the UA-affected testis by restoring the balance between oxidants and antioxidants while obstructing the apoptotic cascade. MLEE contains an abundance of redox-stabilizing and cytoprotective phytochemicals that have the potential to counteract the mechanistic pathways associated with UA exposure. These findings encourage further research into other plausible protective aspects of Moringa oleifera against the UA challenge.

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“…The leaves are also used to treat wounds, fever, sores, bronchitis, eye, and ear infections [41]. Moreover, several studies have shown that the aqueous extracts of M. oleifera leaves possess a wide range of biological actions including antioxidant, tissue protective, cardioprotective, hepatoprotective, neuroprotective [42,43], analgesic [44], diuretic [45], antiulcer [46], anticancer [18], antidiabetic, anti-inflammatory [47], antimicrobial [48], antihypertensive [49], radioprotective [50,51], and immunomodulatory [52,53] effects. Furthermore, it was reported that the administration of an aqueous extract of M. oleifera leaves or seeds manifested potent antihyperglycemic [54,55] and antihyperlipidemic [39,56] effects in insulin-resistant and insulin-deficient rat models [30,57].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antidiabetic Effect of Combined Leaf and Seed Extracts of Moringa oleifera (Moringaceae) on Alloxan-Induced Diabetes in Mice: A Biochemical and Histological Study

Aljazzaf,

Regeai,

Elghmasi

et al. 2023

Oxidative Medicine and Cellular Longevity

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Moringa oleifera (Moringaceae) is a medicinal plant rich in biologically active compounds. The aim of the present study was to screen M. oleifera methanolic leaf (L) extract, seed (S) extract, and a combined leaf/seed extract (2L : 1S ratio) for antidiabetic and antioxidant activities in mice following administration at a dose level of 500 mg/kg of body weight/day. Diabetes was induced by alloxan administration. Mice were treated with the extracts for 1 and 3 months and compared with the appropriate control. At the end of the study period, the mice were euthanized and pancreas, liver, kidney, and blood samples were collected for the analysis of biochemical parameters and histopathology. The oral administration of the combined L/S extract significantly reduced fasting blood glucose to normal levels compared with L or S extracts individually; moreover, a significant decrease in cholesterol, triglycerides, creatinine, liver enzymes, and oxidant markers was observed, with a concomitant increase in antioxidant biomarkers. Thus, the combined extract has stronger antihyperlipidemic and antioxidant properties than the individual extracts. The histopathological results also support the biochemical parameters, showing recovery of the pancreas, liver, and kidney tissue. The effects of the combined L/S extracts persisted throughout the study period tested. To the best of our knowledge, this is the first study to report on the antidiabetic, antioxidant, and antihyperlipidemic effects of a combined L/S extract of M. oleifera in an alloxan-induced diabetic model in mice. Our results suggest the potential for developing a natural potent antidiabetic drug from M. oleifera; however, clinical studies are required.

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Biophysical and biochemical roles of Moringa oleifera leaves as radioprotector

Cited by 12 publications

References 41 publications

The effectiveness of Moringa oleifera in the preservation of periodontium after radiation therapy: An experimental animal study

The effectiveness of Moringa oleifera in the preservation of periodontium after radiation therapy: An experimental animal study

Protective effect of Moringa oleifera leaf ethanolic extract against uranyl acetate-induced testicular dysfunction in rats

Evaluation of Antidiabetic Effect of Combined Leaf and Seed Extracts of Moringa oleifera (Moringaceae) on Alloxan-Induced Diabetes in Mice: A Biochemical and Histological Study

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