Biophysical aspects of neutron scattering from vibrational modes of proteins

Martel, P.

doi:10.1016/0079-6107(92)90023-y

Cited by 56 publications

(19 citation statements)

References 110 publications

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“…Subsequently, low-frequency modes have been indeed observed by Raman spectroscopy for a number of protein molecules [47,48] and different types of DNA [49][50][51][52]. These observed results have also been further confirmed by the neutron scattering experiments [53].…”

Section: Basic Mechanisms Underlying the Efficacy Of Elf-emf Treatmentssupporting

confidence: 73%

Steps to the clinic with ELF EMF

Madkan¹,

Blank²,

Elson³

et al. 2009

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There have been many models to identify and analyze low-frequency motions in protein and DNA molecules. It has been successfully used to simulate various low-frequency collective motions in protein and DNA molecules. Lowfrequency motions in biomacromolecules originate from two common and intrinsic characteristics; i.e., they contain 1) a series of weak bonds, such as hydrogen bonds, and 2) a substantial mass distributed over the region of these weak bonds. Many biological functions and dynamic mechanisms, including cooperative effects have been reported. In this regard, some phenomenological theories were established. However, differences in experimental outcomes are expected since many factors could influence the outcome of experiments in EMF research. Any effect of EMF has to depend on the energy absorbed by a biological organism and on how the energy is delivered in space and time. Frequency, intensity, exposure duration, and the number of exposure episodes can affect the response, and these factors can interact with each other to produce different effects. In addition, in order to understand the biological consequence of EMF exposure, one must know whether the effect is cumulative, whether compensatory responses result, and when homeostasis will break down. Such findings will have great potential for use in translation medicine at the clinical level without being invasive.

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Section: Basic Mechanisms Underlying the Efficacy Of Elf-emf Treatmentssupporting

confidence: 73%

Steps to the clinic with ELF EMF

Madkan¹,

Blank²,

Elson³

et al. 2009

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show abstract

“…In this ®eld, computer simulations have always been essential for interpreting the experimental spectra due to the complexity of the systems [1,2]. The prevalent simulation technique has been molecular dynamics (MD) simulation, which calculates the detailed motion of all atoms.…”

Section: Introductionmentioning

confidence: 99%

Harmonicity in slow protein dynamics

et al. 2000

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“…Since the pioneer paper entitled ''The Biological Functions of Low-Frequency Phonons'' (Chou and Chen, 1977) was published in 1977, a series of investigations into biomacromolecules from dynamic point of view have been stimulated. These studies have suggested that low-frequency (or terahertz frequency) collective motions do exist in proteins and DNA that hold a very high potential to reveal the profound dynamic mechanisms of many marvelous biological functions in biological systems (see, e.g., Chou, 1983aChou, , 1983bChou, , 1984aChou, , 1984bChou, , 1984cChou, , 1985Chou, , 1987Chou, , 1989Chou and Mao, 1988;Chou et al, 1981Chou et al, , 1989Chou et al, , 1994Martel, 1992;Sinkala, 2006), and a comprehensive review (Chou, 1988)). Such inferences have been later observed by NMR (Chou et al, 2001), and applied in medical treatments (Gordon, 2007(Gordon, , 2008Madkan et al, 2009).…”

Section: Resultsmentioning

confidence: 98%