Biophysical characterization of gold nanoparticles-loaded liposomes

Mady, Mohsen M.; Fathy, Mohamed; Youssef, Tareq; Khalil, Wafaa A.

doi:10.1016/j.ejmp.2011.10.001

Cited by 47 publications

(25 citation statements)

References 42 publications

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“…This appropriate size was necessary for a drug delivery system to escape from reticuloendothelial system (RES) system [13,14,37]. This is in accordance with the characteristic previously reported [38,39]. Incorporation of CAMNP into the liposomes changes zeta potential values into −24 mV.…”

Section: Resultssupporting

confidence: 81%

Magnetic liposomes for colorectal cancer cells therapy by high-frequency magnetic field treatment

et al. 2014

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In this study, we developed the cancer treatment through the combination of chemotherapy and thermotherapy using doxorubicin-loaded magnetic liposomes. The citric acid-coated magnetic nanoparticles (CAMNP, ca. 10 nm) and doxorubicin were encapsulated into the liposome (HSPC/DSPE/cholesterol = 12.5:1:8.25) by rotary evaporation and ultrasonication process. The resultant magnetic liposomes (ca. 90 to 130 nm) were subject to characterization including transmission electron microscopy (TEM), dynamic light scattering (DLS), X-ray diffraction (XRD), zeta potential, Fourier transform infrared (FTIR) spectrophotometer, and fluorescence microscope. In vitro cytotoxicity of the drug carrier platform was investigated through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay using L-929 cells, as the mammalian cell model. In vitro cytotoxicity and hyperthermia (inductive heating) studies were evaluated against colorectal cancer (CT-26 cells) with high-frequency magnetic field (HFMF) exposure. MTT assay revealed that these drug carriers exhibited no cytotoxicity against L-929 cells, suggesting excellent biocompatibility. When the magnetic liposomes with 1 μM doxorubicin was used to treat CT-26 cells in combination with HFMF exposure, approximately 56% cells were killed and found to be more effective than either hyperthermia or chemotherapy treatment individually. Therefore, these results show that the synergistic effects between chemotherapy (drug-controlled release) and hyperthermia increase the capability to kill cancer cells.

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Section: Resultssupporting

confidence: 81%

Magnetic liposomes for colorectal cancer cells therapy by high-frequency magnetic field treatment

et al. 2014

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“…[21] Moreover, gold nanoparticles are already used for drug delivery. [22] One of the most important properties of gold nanoparticles is so called "surface plasmon", which results in significant optical absorption in the visible and near-infrared region. The optical properties of Fe 3 O 4 @Au nanoparticles are desired in biological applications, such as imaging and photothermal therapy.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in the synthesis of Fe3O4@AU core/shell nanoparticles

Salihov

Ivanenkov

Krechetov

et al. 2015

Journal of Magnetism and Magnetic Materials

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“…The radiation boost could also be customized by varying the 3-dimensional intra-tumor biodistribution over time as function of CNP size, shape, initial concentration etc. Furthermore, the CNP could be functionalized, as mentioned above, with moieties actively targeting molecular epitopes on tumor cells [2,33]. The location of the smart biomaterial could also be optimized by ensuring the biomaterial is near the target high-risk tumor sub-volume where radiation boosting is most needed.…”

Section: Discussionmentioning

confidence: 99%

New potential for enhancing concomitant chemoradiotherapy with FDA approved concentrations of cisplatin via the photoelectric effect

et al. 2015

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We predict, for the first time, that by using United States Food and Drug Administration approved concentrations of cisplatin, major radiosensitization may be achieved via photoelectric mechanism during concomitant chemoradiotherapy (CCRT). Our analytical calculations estimate that radiotherapy (RT) dose to cancer cells may be enhanced via this mechanism by over 100% during CCRT. The results proffer new potential for significantly enhancing CCRT via an emerging clinical scenario, where the cisplatin is released in-situ from RT biomaterials loaded with cisplatin nanoparticles.

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Biophysical characterization of gold nanoparticles-loaded liposomes

Cited by 47 publications

References 42 publications

Magnetic liposomes for colorectal cancer cells therapy by high-frequency magnetic field treatment

Magnetic liposomes for colorectal cancer cells therapy by high-frequency magnetic field treatment

Recent advances in the synthesis of Fe3O4@AU core/shell nanoparticles

New potential for enhancing concomitant chemoradiotherapy with FDA approved concentrations of cisplatin via the photoelectric effect

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