2019
DOI: 10.1016/j.bbamem.2019.04.004
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Biophysical characterization of mycobacterial model membranes and their interaction with rifabutin: Towards lipid-guided drug screening in tuberculosis

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Cited by 17 publications
(20 citation statements)
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“…Complementary to image‐based viscosity profiling are spectroscopy‐based methods, which offer a quick screening of membrane viscosity using lipid probes and can easily be adapted to a high‐throughput scale (Figure 4B). 156–158 The lipid probe diphenylhexatriene (DPH) intercalates near the acyl chains, with its charged counterpart trimethylamino (TMA)‐DPH being 3–4 Å shallower than DPH 159 . Thus, DPH provides information on the hydrophobic acyl region and TMA‐DPH on the interfacial head group region of the lipid membrane and can be used for the in‐depth understanding of the mechanisms linking chemoresistance to microscopic viscosity changes.…”
Section: The Road Ahead: How To Harness Lipid Membrane Properties For...mentioning
confidence: 99%
See 1 more Smart Citation
“…Complementary to image‐based viscosity profiling are spectroscopy‐based methods, which offer a quick screening of membrane viscosity using lipid probes and can easily be adapted to a high‐throughput scale (Figure 4B). 156–158 The lipid probe diphenylhexatriene (DPH) intercalates near the acyl chains, with its charged counterpart trimethylamino (TMA)‐DPH being 3–4 Å shallower than DPH 159 . Thus, DPH provides information on the hydrophobic acyl region and TMA‐DPH on the interfacial head group region of the lipid membrane and can be used for the in‐depth understanding of the mechanisms linking chemoresistance to microscopic viscosity changes.…”
Section: The Road Ahead: How To Harness Lipid Membrane Properties For...mentioning
confidence: 99%
“…[156][157][158] The lipid probe diphenylhexatriene (DPH) intercalates near the acyl chains, with its charged counterpart trimethylamino (TMA)-DPH being 3-4 Å shallower than DPH. 159 Thus, DPH provides information on the hydrophobic acyl region and TMA-DPH on the interfacial head group region of the lipid membrane and can be used for the in-depth understanding of the mechanisms linking chemoresistance to microscopic viscosity changes.…”
Section: The Road Ahead: How To Harness Lipid Membrane Properties For...mentioning
confidence: 99%
“…Drug‐membrane interactions are becoming increasingly critical in drug discovery [4b,5] . Membrane‐drug interactions are lipid composition‐specific; head group and acyl chain structures, conformations, hydrophobicity, and stereochemistry affect drug passage [3b,6] …”
Section: Introductionmentioning
confidence: 99%
“…Aligning with the approach of lipid-guided drug screening in tuberculosis, Dadhich et al . developed membrane scaffolds specific to mycobacterial OM and demonstrated them as selective and novel platforms for investigating anti-tubercular drug interactions (Dadhich et al 2019 ). Designed membrane scaffolds such as TDM:DAG:DPPG (9.1:18.2:72.7 mol %), TDM:DAG (33.3:66.6 mol %) and TDM were characterized for their interaction with antituberculotic drug, rifabutin.…”
Section: Lipids In Bacterial Infectionsmentioning
confidence: 99%