Biophysical characterization of small molecule antiviral-loaded nanolipogels for HIV-1 chemoprophylaxis and topical mucosal application

Ramanathan, Renuka; Jiang, Yuanchun; Read, Benjamin J.; Golan‐Paz, Sharon; Woodrow, Kim A.

doi:10.1016/j.actbio.2016.02.034

Cited by 21 publications

(14 citation statements)

References 44 publications

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“…Other more complex molecules have also been considered (e.g., fusion inhibitor peptides [57], RANTES analogues [58,59], or siRNA [60]). Polymeric NPs have been amongst the most popular nanocarriers used [61], although solid lipid NPs [62], liposomes [63], or nanolipogels [64] have been considered as alternatives. Furthermore, nanofibers attracted great interest as vaginal microbicides due to their ability to modulate drug release, provide fast distribution of incorporated compounds, and allow formulation of multiple active molecules in the same system [65].…”

Section: Potential Of Nanotechnology In Developing Microbicidesmentioning

confidence: 99%

Pharmaceutical Vehicles for Vaginal and Rectal Administration of Anti-HIV Microbicide Nanosystems

et al. 2019

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Prevention strategies play a key role in the fight against HIV/AIDS. Vaginal and rectal microbicides hold great promise in tackling sexual transmission of HIV-1, but effective and safe products are yet to be approved and made available to those in need. While most efforts have been placed in finding and testing suitable active drug candidates to be used in microbicide development, the last decade also saw considerable advances in the design of adequate carrier systems and formulations that could lead to products presenting enhanced performance in protecting from infection. One strategy demonstrating great potential encompasses the use of nanosystems, either with intrinsic antiviral activity or acting as carriers for promising microbicide drug candidates. Polymeric nanoparticles, in particular, have been shown to be able to enhance mucosal distribution and retention of promising antiretroviral compounds. One important aspect in the development of nanotechnology-based microbicides relates to the design of pharmaceutical vehicles that allow not only convenient vaginal and/or rectal administration, but also preserve or even enhance the performance of nanosystems. In this manuscript, we revise relevant work concerning the selection of vaginal/rectal dosage forms and vehicle formulation development for the administration of microbicide nanosystems. We also pinpoint major gaps in the field and provide pertinent hints for future work.

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Section: Potential Of Nanotechnology In Developing Microbicidesmentioning

confidence: 99%

Pharmaceutical Vehicles for Vaginal and Rectal Administration of Anti-HIV Microbicide Nanosystems

et al. 2019

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“…Moreover, this virus infection induced high mortality rate and long incubation period [114]. A composite system was fabricated by Ramanathan et al [115] using hydrogel as a core structure and a phospholipid bilayer as shell structure to carry maraviroc and tenofovir disoproxil fumarate. This system was applied in the treatment of HIV in mouse by absorbing in mouse vaginal mucosa, leading to antiviral activity against HIV-1 BaL in cervicovaginal lavages.…”

Section: Human Immunodeficiency Virus (Hiv)mentioning

confidence: 99%

Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications

et al. 2020

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Liposome is one of the most commonly used drug delivery systems in the world, due to its excellent biocompatibility, satisfactory ability in controlling drug release, and passive targeting capability. However, some drawbacks limit the application of liposomes in clinical, such as problems in transporting, storing, and difficulties in maintaining the drug concentration in the local area. Scaffolds usually are used as implants to supply certain mechanical supporting to the defective area or utilized as diagnosis and imaging methods. But, in general, unmodified scaffolds show limited abilities in promoting tissue regeneration and treating diseases. Therefore, liposome-scaffold composite systems are designed to take advantages of both liposomes' biocompatibility and scaffolds' strength to provide a novel system that is more suitable for clinical applications. This review introduces and discusses different types of liposomes and scaffolds, and also the application of liposome-scaffold composite systems in different diseases, such as cancer, diabetes, skin-related diseases, infection and human immunodeficiency virus, and in tissue regeneration like bone, teeth, spinal cord and wound healing.Journal Pre-proof Drug-loaded liposomesLiposomes have been widely investigated as drug carriers, from the approved amphotericin B liposome in 1990 to the successful Onivyde™ in 2015. As drug carriers, liposomes have several advantages, for instance, they can carry various types of drugs, specifically, the internal water core can load hydrophilic drugs and the bilayers can carry hydrophobic ones. Additionally, liposomes exhibit the ability in controlling the drug release and decreasing the side effect of drugs. Furthermore, liposomes also show advantages in low toxicity, non-immunogenic and biodegradability. The phospholipid bilayer can be regarded as satisfactory platforms that can be modified with diverse ligands to achieve the goal of targeting delivery. Furthermore, the stability and efficacy of biological products can also be improved by utilizing liposomes as vehicles. Delivering small molecule hydrophilic drugsSeveral methods, such as reverse evaporation, pH gradient, ammonium sulfate gradient and repeated freeze thawing, are usually applied in the process of preparing small hydrophilic drugs-loaded liposomes. For example, Takeuchi et al. [14] fabricated polyborane encapsulated liposomes though pH gradient or reverse-phase evaporation, then they found that for the encapsulation efficiency of the liposome Journal Pre-proof 6 prepared using the pH gradient was twice as high as that prepared, using reverse-phase evaporation. Additionally, they observed that boron concentration of the polyborane encapsulated liposomes prepared using the pH gradient achieved 110-150 μg/g of tumor tissue. Delivering small molecule hydrophobic drugsUsually the film dispersion method is one of the simplest ways to fabricate lipid drug-loaded liposomes. For example, Fu et al.[15] fabricated novel temperature-sensitive liposomes loading paclitaxel (PTX-...

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“…Ramanathan, Jiang et al [ 146 ] investigated the capability of hybrid nanoparticles composed of a hydrogel-core and a lipid-shell for improving the antiviral activity of tenofovir disoproxil fumarate (TDF) and maraviroc (MVC) toward HIV. A sustained release of both MVC and TDF was obtained by incorporation of them within these lipogel nanoparticles.…”

Section: Nanoparticle Delivery Systems In Antiviral Therapymentioning

confidence: 99%

Development of nanoparticle-delivery systems for antiviral agents: A review

Delshadi¹,

Bahrami

McClements

et al. 2021

Journal of Controlled Release

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Biophysical characterization of small molecule antiviral-loaded nanolipogels for HIV-1 chemoprophylaxis and topical mucosal application

Cited by 21 publications

References 44 publications

Pharmaceutical Vehicles for Vaginal and Rectal Administration of Anti-HIV Microbicide Nanosystems

Pharmaceutical Vehicles for Vaginal and Rectal Administration of Anti-HIV Microbicide Nanosystems

Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications

Development of nanoparticle-delivery systems for antiviral agents: A review

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