Biophysical interactions of mixed lipid-polymer nanoparticles incorporating curcumin: Potential as antibacterial agent

Naziris, Nikolaos; Sękowski, Szymon; Grabarek, Ewa Olchowik; Buczkowski, Adam; Balcerzak, Łucja; Chrysostomou, Varvara; Pispas, Stergios; Małecka, Magdalena; Bryszewska, Maria; Йонов, Максим

doi:10.1016/j.bioadv.2022.213200

Cited by 10 publications

(8 citation statements)

References 64 publications

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“…Quirós-Fallas and colleagues fabricated a composite fortified with lipid nanoparticles incorporating curcumin and showed effective antioxidant properties and immune-stimulating effects with biocompatibility impacts on malignant cell lines [ 66 ]. In another study, curcumin nanoparticles were formulated, demonstrating superior anti-bacterial properties against potential pathogenic microorganisms and the apoptosis of cells [ 67 ]. By triggering apoptosis in cells due to caspase activation, inhibiting NF activation, and upregulating TNF-R for SLNs when in comparison with unbound curcumin in human carcinoma cell lines, Vandita et al demonstrated a 32- to 155-fold rise in bioavailability for curcumin when used alongside the SLNs ( Figure 4 ) [ 68 ].…”

Section: Natural Bioactive Compounds In Lipid-based Drug Delivery Sys...mentioning

confidence: 99%

Lipid-Based Nanoparticles in Delivering Bioactive Compounds for Improving Therapeutic Efficacy

Patel,

Garala,

Singh

et al. 2024

Pharmaceuticals

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In recent years, due to their distinctive and adaptable therapeutic effects, many natural bioactive compounds have been commonly used to treat diseases. Their limited solubility, low bioavailability, inadequate gastrointestinal tract stability, high metabolic rate, and shorter duration of action limited their pharmaceutical applications. However, those can be improved using nanotechnology to create various drug delivery systems, including lipid-based nanoparticles, to adjust the compounds’ physicochemical properties and pharmacokinetic profile. Because of the enormous technical advancements made in the fundamental sciences and the physical and chemical manipulation of individual atoms and molecules, the subject of nanotechnology has experienced revolutionary growth. By fabricating certain functionalized particles, nanotechnology opens an innovative horizon in research and development for overcoming restrictions, including traditional medication administration systems. Nanotechnology-driven bioactive compounds are certain to have a high impact and clinical value for current and future uses. Lipid-based nanotechnologies were shown to deliver a range of naturally occurring bioactive compounds with decent entrapment potential and stability, a successfully controlled release, increased bioavailability, and intriguing therapeutic activity. This review outlines bioactive compounds such as paclitaxel, curcumin, rhodomyrtone, quercetin, kaempferol, resveratrol, epigallocatechin-3-gallate, silymarin, and oridonin, fortified within either a natural or synthetic lipid-based drug delivery system based on nanotechnology and their evaluation and clinical considerations.

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Section: Natural Bioactive Compounds In Lipid-based Drug Delivery Sys...mentioning

confidence: 99%

Lipid-Based Nanoparticles in Delivering Bioactive Compounds for Improving Therapeutic Efficacy

Patel,

Garala,

Singh

et al. 2024

Pharmaceuticals

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“…Quirós-Fallas and coworkers developed curcumin-loaded hybrid lipid polymeric nanoparticles and demonstrated efficient antioxidant activity, immune-stimulant response, and cytotoxic effect against both gastric and colon cancer cell lines [274]. Naziris and coworkers developed curcumin-loaded mixed lipid-polymer nanoparticles and found higher interaction of the system with bacterial membrane proteins leading to an efficient antibacterial effect [275]. Abosabaa and coworkers developed green tea extract-loaded hybrid chitosan-lipid nanoparticles.…”

Section: Recent Advancesmentioning

confidence: 99%

Polymeric Nanoparticles for Delivery of Natural Bioactive Agents: Recent Advances and Challenges

et al. 2023

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In the last few decades, several natural bioactive agents have been widely utilized in the treatment and prevention of many diseases owing to their unique and versatile therapeutic effects, including antioxidant, anti-inflammatory, anticancer, and neuroprotective action. However, their poor aqueous solubility, poor bioavailability, low GIT stability, extensive metabolism as well as short duration of action are the most shortfalls hampering their biomedical/pharmaceutical applications. Different drug delivery platforms have developed in this regard, and a captivating tool of this has been the fabrication of nanocarriers. In particular, polymeric nanoparticles were reported to offer proficient delivery of various natural bioactive agents with good entrapment potential and stability, an efficiently controlled release, improved bioavailability, and fascinating therapeutic efficacy. In addition, surface decoration and polymer functionalization have opened the door to improving the characteristics of polymeric nanoparticles and alleviating the reported toxicity. Herein, a review of the state of knowledge on polymeric nanoparticles loaded with natural bioactive agents is presented. The review focuses on frequently used polymeric materials and their corresponding methods of fabrication, the needs of such systems for natural bioactive agents, polymeric nanoparticles loaded with natural bioactive agents in the literature, and the potential role of polymer functionalization, hybrid systems, and stimuli-responsive systems in overcoming most of the system drawbacks. This exploration may offer a thorough idea of viewing the polymeric nanoparticles as a potential candidate for the delivery of natural bioactive agents as well as the challenges and the combating tools used to overcome any hurdles.

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“…61 S. aureus is affected by CUR through the inhibition of sortase A, a surface protein that anchors the transpeptidase (cell membrane structure), as well as the inhibition of fibronectin-binding protein, related to cell adhesion. 65,66 In relation to S. epidermidis, mechanisms are not yet elucidated; however, MIC results were in agreement with previous studies. 67 Furthermore, CUR is also able to bind to and suppress the FtsZ cytoskeletal protein, related to the cell division and proliferation 68 in several eukaryotes.…”

Section: Chemical Mapping Via Atomic Force Microscopy-mentioning

confidence: 99%

Selection and Control of Process Conditions Enable the Preparation of Curcumin-Loaded Poly(lactic-co-glycolic acid) Nanoparticles of Superior Performance

Feltrin

D'Angelo

Guarnieri

et al. 2023

ACS Appl. Mater. Interfaces

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Curcumin (CUR) is one natural bioactive compound acknowledged for diverse therapeutic activities, but its use is hindered by its poor bioavailability, fast metabolism, and susceptibility to pH variations and light exposure. Thus, the encapsulation in poly(lactic-co-glycolic acid), or PLGA, has been successfully used to protect and enhance CUR absorption in the organism, making CUR-loaded PLGA nanoparticles (NPs) promising drug delivery systems. However, few studies have focused beyond CUR bioavailability, on the environmental variables involved in the encapsulation process, and whether they could help obtain NPs of superior performance. Our study evaluated pH (3.0 or 7.0), temperature (15 or 35 °C), light exposure, and inert atmosphere (N2) incidence in the encapsulation of CUR. The best outcome was at pH 3.0, 15 °C, without light incidence, and without N2 usage. This best nanoformulation showed NP size, zeta potential, and encapsulation efficiency (EE) of 297 nm, −21 mV, and 72%, respectively. Moreover, the CUR in vitro release at pH values 5.5 and 7.4 suggested different potential applications for these NPs, one of which was demonstrated by the effective inhibition of multiple bacteria (i.e., Gram-negative, Gram-positive, and multi-resistant) in the minimal inhibition concentration assay. Besides, statistical analyses confirmed a significant impact of temperature on the NP size; in addition, temperature, light, and N2 affected the EE of CUR. Thus, the selection and control of process variables resulted in higher CUR encapsulation and customizable outcomes, ultimately enabling more economical processes and providing future scale-up guidelines.

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Biophysical interactions of mixed lipid-polymer nanoparticles incorporating curcumin: Potential as antibacterial agent

Cited by 10 publications

References 64 publications

Lipid-Based Nanoparticles in Delivering Bioactive Compounds for Improving Therapeutic Efficacy

Lipid-Based Nanoparticles in Delivering Bioactive Compounds for Improving Therapeutic Efficacy

Polymeric Nanoparticles for Delivery of Natural Bioactive Agents: Recent Advances and Challenges

Selection and Control of Process Conditions Enable the Preparation of Curcumin-Loaded Poly(lactic-co-glycolic acid) Nanoparticles of Superior Performance

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