Biophysical investigation of the interfacial properties of cationic fluorocarbon/hydrocarbon hybrid surfactant: Mimicking the lung surfactant protein C

Aydoğan, Nihal; Uslu, Burcin; Tanacı, Hacer

doi:10.1016/j.jcis.2011.04.018

Cited by 16 publications

(17 citation statements)

References 59 publications

(117 reference statements)

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“…The difference between compression and expansion isotherms is small, considering that it was only performed at the first cycle, which is essential for an efficient PS [32,43]. The maximum C s −1 calculated for Curosurf® was 439 mN/m (Table 1), close to the value for pure DPPC [44,55].…”

Section: Comparison Of Compression Isothermsmentioning

confidence: 58%

“…This parameter was determined by extrapolation of a line tangent to the condensed region. Hysteresis was acquired by the monolayer compression/decompression isotherms and corresponds to the difference between compression and decompression areas [32]. The cycle of compression/decompression was performed to mimic the expiration/inspiration movements, respectively.…”

Section: Parameters Studied From the Surface Pressure-area Langmuir Imentioning

confidence: 99%

“…The hydrophobic proteins present in Curosurf® are surfactant protein B (SP-B) (0.4% w/w) and SP-C (0.7% w/w), which extensively interact with the surfactant phospholipids and increase their ability to efficiently decrease the surface tension [9,29]. These proteins are cationic due to the positively charged arginine and lysine amino acids present in their composition [31,32].…”

Section: Introductionmentioning

confidence: 99%

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Interplay of mycolic acids, antimycobacterial compounds and pulmonary surfactant membrane: A biophysical approach to disease

Pinheiro

Giner‐Casares

Lúcio

et al. 2013

Biochimica et Biophysica Acta (BBA) - Biomembranes

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This work focuses on the interaction of mycolic acids (MAs) and two antimycobacterial compounds (Rifabutin and N'-acetyl-Rifabutin) at the pulmonary membrane level to convey a biophysical perspective of their role in disease. For this purpose, accurate biophysical techniques (Langmuir isotherms, Brewster angle microscopy, and polarization-modulation infrared reflection spectroscopy) and lipid model systems were used to mimic biomembranes: MAs mimic bacterial lipids of the Mycobacterium tuberculosis (MTb) membrane, whereas Curosurf® was used as the human pulmonary surfactant (PS) membrane model. The results obtained show that high quantities of MAs are responsible for significant changes on PS biophysical properties. At the dynamic inspiratory surface tension, high amounts of MAs decrease the order of the lipid monolayer, which appears to be a concentration dependent effect. These results suggest that the amount of MAs might play a critical role in the initial access of the bacteria to their targets. Both molecules also interact with the PS monolayer at the dynamic inspiratory surface. However, in the presence of higher amounts of MAs, both compounds improve the phospholipid packing and, therefore, the order of the lipid surfactant monolayer. In summary, this work discloses the putative protective effects of antimycobacterial compounds against the MAs induced biophysical impairment of PS lipid monolayers. These protective effects are most of the times overlooked, but can constitute an additional therapeutic value in the treatment of pulmonary tuberculosis (Tb) and may provide significant insights for the design of new and more efficient anti-Tb drugs based on their behavior as membrane ordering agents.

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Section: Comparison Of Compression Isothermsmentioning

confidence: 58%

Section: Parameters Studied From the Surface Pressure-area Langmuir Imentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Interplay of mycolic acids, antimycobacterial compounds and pulmonary surfactant membrane: A biophysical approach to disease

Pinheiro

Giner‐Casares

Lúcio

et al. 2013

Biochimica et Biophysica Acta (BBA) - Biomembranes

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“…Furthermore, bolaform surfactants are also relevant for biochemistry and pharmaceutical applications, by modeling lipid membranes [327][328][329], as permeability enhancers [330] or to be used for drugs encapsulation [331], respectively.…”

Section: Bolaform Surfactantsmentioning

confidence: 99%

The formation of host–guest complexes between surfactants and cyclodextrins

Valente

Söderman

2014

Advances in Colloid and Interface Science

183

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Cyclodextrins are able to act as host molecules in supramolecular chemistry with applications ranging from pharmaceutics to detergency. Among guest molecules surfactants play an important role with both fundamental and practical applications. The formation of cyclodextrin/surfactant host-guest compounds leads to an increase in the critical micelle concentration and in the solubility of surfactants. The possibility of changing the balance between several intermolecular forces, and thus allowing the study of, e.g., dehydration and steric hindrance effects upon association, makes surfactants ideal guest molecules for fundamental studies. Therefore, these systems allow for obtaining a deep insight into the host-guest association mechanism. In this paper, we review the influence on the thermodynamic properties of CD-surfactant association by highlighting the effect of different surfactant architectures (single tail, double-tailed, gemini and bolaform), with special emphasis on cationic surfactants. This is complemented with an assessment of the most common analytical techniques used to follow the association process. The applied methods for computation of the association stoichiometry and stability constants are also reviewed and discussed; this is an important point since there are significant discrepancies and scattered data for similar systems in the literature.In general, the surfactant-cyclodextrin association is treated without reference to the kinetics of the process. However, there are several examples where the kinetics of the process can be investigated, in particular those where volumes of the CD cavity and surfactant (either the tail or in special cases the head group) are similar in magnitude.This will also be critically reviewed.

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“…It is indicative of both the molecular packing and the interactions between the monolayer components. [27][28][29] The p collapse value corresponds to the beginning of a plateau region in the isotherm in which the surface pressure remains constant even with decreasing area, and is indicative of the stability of the monolayer. [30] The p-A isotherms of EPC:CHOL (4:1) on phosphate buffer in the absence and in the presence of the antimycobacterial compounds are shown in Figure 2.…”

Section: Surface Pressure-molecular Area Isothermsmentioning

confidence: 99%

Evaluation of the Structure–Activity Relationship of Rifabutin and Analogs: A Drug–Membrane Study

et al. 2013

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This work focuses on the influence of rifabutin and two novel analogs, namely, N'-acetyl-rifabutin and N'-butanoyl-rifabutin, on the biophysical properties of lipid membranes. Monolayers and multilamellar vesicles composed of egg L-α-phosphatidylcholine:cholesterol in a molar ratio of 4:1 are chosen to mimic biological membranes. Several accurate biophysical techniques are used to establish a putative relationship between the chemical structure of the antimycobacterial compounds and their activity on the membranes. A combination of in situ experimental techniques, such as Langmuir isotherms, Brewster angle microscopy, polarization-modulated infrared reflection-absorption spectroscopy, and small-angle X-ray scattering, is used to assess the drug-membrane interaction. A relationship between the effect of a drug on the organization of the membranes and their chemical structure is found and may be useful in the development of new drugs with higher efficacy and fewer toxic effects.

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Biophysical investigation of the interfacial properties of cationic fluorocarbon/hydrocarbon hybrid surfactant: Mimicking the lung surfactant protein C

Cited by 16 publications

References 59 publications

Interplay of mycolic acids, antimycobacterial compounds and pulmonary surfactant membrane: A biophysical approach to disease

Interplay of mycolic acids, antimycobacterial compounds and pulmonary surfactant membrane: A biophysical approach to disease

The formation of host–guest complexes between surfactants and cyclodextrins

Evaluation of the Structure–Activity Relationship of Rifabutin and Analogs: A Drug–Membrane Study

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