Biophysical modeling of excitability and membrane integration at the single cell and network levels

From spinal cord to hippocampus: links between bifurcation structure, ion channel expression, and firing patterns in a variety of neuron types

“…Neurons throughout the brain show remarkable diversity in their firing patterns, ranging from the generation of single action potentials to repetitive firing characterized by distinct latencies, firing frequencies, and spike shapes in response to current injection [ 3 - 5 ]. We present a minimal electrodiffusion-based model of membrane potential dynamics [ 1 , 2 ] to explore the diversity of firing patterns in a variety of neuron types, including spinal motor neurons and hippocampal granule cells. The minimal model includes voltage-gated sodium and potassium currents as well as a non-voltage-gated leak current.…”