2015
DOI: 10.1021/acs.langmuir.5b01639
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Biophysicochemical Interaction of a Clinical Pulmonary Surfactant with Nanoalumina

Abstract: We report on the interaction of pulmonary surfactant composed of phospholipids and proteins with nanometric alumina (Al 2 O 3 ) in the context of lung exposure and nanotoxicity. We study the bulk properties of phospholipid/nanoparticle dispersions and determine the nature of their interactions. The clinical surfactant Curosurf®, both native and extruded, and a protein-free surfactant are investigated. The phase behavior of mixed surfactant/particle dispersions was determined by optical and electron microscopy,… Show more

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Cited by 37 publications
(81 citation statements)
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“…below and above the gel-to-fluid transition of Curosurf® membrane at 29.5 °C (Supplementary Information S2). 8,48 The outcomes of Fig. 1 suggest a strong electrostatic attraction between the oppositely charged NPs and vesicles.…”
Section: Ii1 -Nanoparticles Curosurf® Vesicles and Interactionmentioning
confidence: 93%
“…below and above the gel-to-fluid transition of Curosurf® membrane at 29.5 °C (Supplementary Information S2). 8,48 The outcomes of Fig. 1 suggest a strong electrostatic attraction between the oppositely charged NPs and vesicles.…”
Section: Ii1 -Nanoparticles Curosurf® Vesicles and Interactionmentioning
confidence: 93%
“…[42,46,47] TiO 2 nanoparticles were obtained from Nano-structured & Amorphous Material Inc (Houston, TX, USA) as a 150 g L −1 dispersion. [52,53] The CeO 2 , TiO 2 , γ-Fe 2 O 3 , and Al 2 O 3 nanoparticles were also studied by dynamic light scattering, revealing hydrodynamic diameters D H of 9.6, 46.2, 29.8, and 55.3 nm, respectively. Some small size aggregates are also observed in the TEM image.…”
Section: Nanoparticlesmentioning
confidence: 99%
“…Particles have the shape of irregular platelets of sizes 41.5 nm in length and 10 nm in thickness. [52,53] The CeO 2 , TiO 2 , γ-Fe 2 O 3 , and Al 2 O 3 nanoparticles were also studied by dynamic light scattering, revealing hydrodynamic diameters D H of 9.6, 46.2, 29.8, and 55.3 nm, respectively. For cerium, iron, and aluminum oxide nanoparticles, the differences found between the geometric and hydrodynamic diameters are attributed to the particle size and shape dispersity.…”
Section: Nanoparticlesmentioning
confidence: 99%
“…In particular they exhibit excellent temporal stability, allowing to perform extended characterization and interaction experiments. 34 Despite many efforts, the mechanisms of particles interacting with the pulmonary surfactant are not fully understood. The question of the nature of the physico-chemical interactions is central, as these interactions modify the particle biological identity and regulate its transfer through the air-blood barrier.…”
Section: -Introductionmentioning
confidence: 99%