Biophysics involved in the process of tumor immune escape

Wang, Maonan; Jiang, Hui; Liu, Xiaohui; Wang, Xuemei

doi:10.1016/j.isci.2022.104124

Cited by 7 publications

(4 citation statements)

References 141 publications

(190 reference statements)

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“…CAFs also strongly contribute to generating and maintaining an immune-suppressed microenvironment by secreting WNT-2, a suppressor in differentiating and activating dendritic cells [ 54 ]. Furthermore, the drop-in of the anti-tumor T-cells and their contact with tumor cells is hampered by a stiff TME contributing to immune exclusion [ 16 , 55 , 56 ].…”

Section: Cancer-associated Fibroblasts In the Tumor Microenvironmentmentioning

confidence: 99%

Cancer-Associated Fibroblasts and Extracellular Matrix: Therapeutical Strategies for Modulating the Cholangiocarcinoma Microenvironment

Minini

Fouassier

2023

Current Oncology

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During the last decade, immunotherapy has radically changed perspectives on anti-tumor treatments. However, solid tumor treatment by immunotherapy has not met expectations. Indeed, poor clinical response to treatment has highlighted the need to understand and avoid immunotherapy resistance. Cholangiocarcinoma (CCA) is the second cause of hepatic cancer-related deaths because of drug inefficacy and chemo-resistance in a majority of patients. Thus, intense research is ongoing to better understand the mechanisms involved in the chemo-resistance processes. The tumor microenvironment (TME) may be involved in tumor therapy resistance by limiting drug access. Indeed, cells such as cancer-associated fibroblasts (CAFs) alter TME by producing in excess an aberrant extracellular matrix (ECM). Interestingly, CAFs are the dominant stromal component in CCA that secrete large amounts of stiff ECM. Stiff ECM could contribute to immune exclusion by limiting anti-tumor T-cells drop-in. Herein, we summarize features, functions, and interactions among CAFs, tumor-associated ECM, and immune cells in TME. Moreover, we discuss the strategies targeting CAFs and the remodeling of the ECM to improve immunotherapy and drug therapies.

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Section: Cancer-associated Fibroblasts In the Tumor Microenvironmentmentioning

confidence: 99%

Cancer-Associated Fibroblasts and Extracellular Matrix: Therapeutical Strategies for Modulating the Cholangiocarcinoma Microenvironment

Minini

Fouassier

2023

Current Oncology

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“…The confined migration of cancer cells has also been shown to promote resistance to anoikis and NK cell-mediated immune surveillance, although the translational consequences of this have not yet been evaluated [ 90 ]. Beyond mechanical stresses, mechanical properties such as stiffness and viscoelasticity can also promote tumor immune escape, as reviewed by M. Wang and colleagues, rationalizing further investigation [ 91 ]. However, the direct induction of immune evasion—involving any of the immune cells discussed here—by mechanical stresses has not been casually demonstrated (e.g., via in vivo force application [ 92 ]) and the potential relevance to the immunotherapeutic response has not been studied.…”

Section: Potential Implications Of Tumor Mechanical Stress-induced Im...mentioning

confidence: 99%

Do Tumor Mechanical Stresses Promote Cancer Immune Escape?

Onwudiwe

Najera

Siri

et al. 2022

Cells

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Immune evasion—a well-established cancer hallmark—is a major barrier to immunotherapy efficacy. While the molecular mechanisms and biological consequences underpinning immune evasion are largely known, the role of tissue mechanical stresses in these processes warrants further investigation. The tumor microenvironment (TME) features physical abnormalities (notably, increased fluid and solid pressures applied both inside and outside the TME) that drive cancer mechanopathologies. Strikingly, in response to these mechanical stresses, cancer cells upregulate canonical immune evasion mechanisms, including epithelial–mesenchymal transition (EMT) and autophagy. Consideration and characterization of the origins and consequences of tumor mechanical stresses in the TME may yield novel strategies to combat immunotherapy resistance. In this Perspective, we posit that tumor mechanical stresses—namely fluid shear and solid stresses—induce immune evasion by upregulating EMT and autophagy. In addition to exploring the basis for our hypothesis, we also identify explicit gaps in the field that need to be addressed in order to directly demonstrate the existence and importance of this biophysical relationship. Finally, we propose that reducing or neutralizing fluid shear stress and solid stress-induced cancer immune escape may improve immunotherapy outcomes.

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“…Moreover, dynamic ECM factors (e.g., laminin) play key roles in determining the characteristics of the BCSFB and capillaries in the ChP [ 31 ]. In addition to ChP physiology, the dynamic conditions can significantly affect the tumor microenvironment (TME), including its immune system [ [32] , [33] , [34] , [35] , [36] ]. The effects of CSF flow dynamics on drug responses in the brain are also regarded as critical factors, but they remain unexplored [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

Engineering choroid plexus-on-a-chip with oscillatory flow for modeling brain metastasis

Lim,

Rhee,

Choi

et al. 2023

Materials Today Bio

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Biophysics involved in the process of tumor immune escape

Cited by 7 publications

References 141 publications

Cancer-Associated Fibroblasts and Extracellular Matrix: Therapeutical Strategies for Modulating the Cholangiocarcinoma Microenvironment

Cancer-Associated Fibroblasts and Extracellular Matrix: Therapeutical Strategies for Modulating the Cholangiocarcinoma Microenvironment

Do Tumor Mechanical Stresses Promote Cancer Immune Escape?

Engineering choroid plexus-on-a-chip with oscillatory flow for modeling brain metastasis

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