2013
DOI: 10.1016/j.addr.2013.09.004
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Biophysics of cell membrane lipids in cancer drug resistance: Implications for drug transport and drug delivery with nanoparticles

Abstract: In this review, we focus on the biophysics of cell membrane lipids, particularly when cancers develop acquired drug resistance, and how biophysical changes in resistant cell membrane influence drug transport and nanoparticle-mediated drug delivery. Recent advances in membrane lipid research show the varied roles of lipids in regulating membrane P-glycoprotein function, membrane trafficking, apoptotic pathways, drug transport, and endocytic functions, particularly endocytosis, the primary mechanism of cellular … Show more

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Cited by 235 publications
(226 citation statements)
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“…It is important to note that ABCB1 is in a mutual relationship with its membrane environment, that is, not only the membrane lipids alter the function of ABCB1 but this protein may actively modify its lipid environment (for reviews, see Denning & Beckstein, 2013;Orlowski et al, 2006;Peetla, Vijayaraghavalu, & Labhasetwar, 2013;Pohl, Devaux, & Herrmann, 2005;Sharom, 2014). ABCG2 is less characterized in this respect, but lipid interactions certainly affect its function.…”
Section: P0100mentioning
confidence: 99%
See 1 more Smart Citation
“…It is important to note that ABCB1 is in a mutual relationship with its membrane environment, that is, not only the membrane lipids alter the function of ABCB1 but this protein may actively modify its lipid environment (for reviews, see Denning & Beckstein, 2013;Orlowski et al, 2006;Peetla, Vijayaraghavalu, & Labhasetwar, 2013;Pohl, Devaux, & Herrmann, 2005;Sharom, 2014). ABCG2 is less characterized in this respect, but lipid interactions certainly affect its function.…”
Section: P0100mentioning
confidence: 99%
“…MDR-ABC transporters may actively alter the membrane lipid environment p0250 Since ABCB1 and ABCG2 transport hydrophobic compounds, they may significantly modulate the composition of the plasma membrane around their residing areas. Several publications revealed differences in the lipid composition of parental and MDR-ABC-expressing drug-resistant cell line pairs (Hinrichs, Klappe, & Kok, 2005;Peetla et al, 2013). ABCB1 has indeed been shown to be capable of the outward transport of NBD labeled or radiolabeled short PC and PE analogues (Bosch, Dunussi-Joannopoulos, Wu, Furlong, & Croop, 1997;van Helvoort et al, 1996).…”
Section: Article In Pressmentioning
confidence: 99%
“…2 Variations in sphingolipid membrane composition were observed between anticancer drug-resistant cells compared with the drug-sensitive ones, and SM level increases were shown to be associated with doxorubicin resistances in P388, T47D, and MCF-7/ADR cells. 3,4 Strategies to interfere with sphingolipid metabolism were largely studied.…”
Section: Introductionmentioning
confidence: 99%
“…Lipids play a major role in the regulation of membrane trafficking and endocytosis, the primary mechanism of uptake of nanoparticle-based systems. 39 Vijayaraghavalu et al investigated the use of Doxil ® , the liposomal formulation of doxorubicin, in delivering doxorubicin to resistant breast cancer cells. 40 The compact and rigid nature of drug-resistant cell membranes resulted in impaired endocytic function that inhibited intracellular drug delivery using Doxil.…”
Section: Intracellular Accumulation Of Gns Within Ibc Tumor Emboli Almentioning
confidence: 99%