Biopolymer‐Assembled Porous Hydrogel Microfibers from Microfluidic Spinning for Wound Healing

Abstract

Hydrogels are considered as a promising medical patch for wound healing. Researches in this aspect are focused on improving their compositions and permeability to enhance the effectiveness of wound healing. Here, novel prolamins‐assembled porous hydrogel microfibers with the desired merits for treating diabetes wounds are presented. Such microfibers are continuously generated by one‐step microfluidic spinning technology with acetic acid solution of prolamins as the continuous phase and deionized water as the dispersed phase. By adjusting the prolamin concentration and flow rates of microfluidics, the porous structure and morphology as well as diameters of microfibers can be well tailored. Owing to their porosity, the resultant microfibers can be employed as flexible delivery systems for wound healing actives, such as bacitracin and vascular endothelial growth factor (VEGF). It is demonstrated that the resultant hydrogel microfibers are with good cell‐affinity and effective drug release efficiency, and their woven patches display superior in vivo capability in treating diabetes wounds. Thus, it is believed that the proposed prolamins‐assembled porous hydrogel microfibers will show important values in clinic wound treatments.

Toward the Next Generation Human–Machine Interaction: Headworn Wearable Devices

“…One of the important characteristics of microfluidics is that it has unique fluid properties in the microscale environment, such as laminar flow and droplets. With the help of these unique fluid phenomena, microfluidics can realize a series of micromachining and micromanipulation processes that are difficult to accomplish by conventional methods. − A simple microfluidic system can be a single microchannel, while a complex system may be a tiny microchannel. At present, microfluidics are considered to have great development potential and wide application prospects in biomedical research. − As of now, there are many studies and reviews on wearable devices, and there are also many reviews involving microfluidics.…”