Biopolymer coating of soybean lecithin liposomes via layer-by-layer self-assembly as novel delivery system for ellagic acid

Madrigal‐Carballo, Sergio; Lim, Seokwon; Rodríguez, Gerardo; Vila, A.O.; Krueger, Christian G.; Gunasekaran, Sundaram; Reed, Jess D.

doi:10.1016/j.jff.2010.01.002

Cited by 103 publications

(54 citation statements)

References 30 publications

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“…El uso de polímeros tanto sintéticos (Hristova, Kenworthy y McIntosh, 1995;Hristova y Needham, 1995;Kenworthy, Simon y McIntosh, 1995;Robertson et al, 2004;Sou, Endo, Takeoka y Tsuchida, 2000) como naturales (Madrigal-Carballo et al, 2010) ha sido también reportado en la bibliografía. La estabilización mediante la adsorción de sus cadenas iónicas o neutras sobre la superficie de las vesículas genera una barrera estérica o electro estérica que evita la colisión entre las partículas.…”

Section: Palavras-chavesunclassified

Caracterización estructural de vesículas modificadas con quitosano

Soto-Cruz

Alvarado-Aguilar

Vega-Baudrit³

et al. 2018

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Vesículas a base de L-α-fosfatidilcolina (PC) y mezclas de PC/fosfogliceroles fueron caracterizadas por medio de dispersión de luz dinámica (DLS), microscopía electrónica de barrido-criogénico (Cryo-SEM) y calorimetría de titulación isotérmica (ITC). La incorporación de fosfogliceroles en la formulación de vesículas a base PC disminuyó el tamaño y la polidispersidad de las partículas, debido a un mayor empaquetamiento de las cadenas alifáticas por medio de interacciones de van der Waals. Además, resultó en una disminución significativa de la carga superficial de -75 mV comparada con el potencial Z (ξ) de las vesículas a base de PC. Ambos sistemas fueron modificados usando un polielectrolito catiónico (quitosano) de un peso molecular de 865 kDa y con un grado de desacetilación de 77 %. La naturaleza aniónica de la vesícula fosfolipídica resultó en una efectiva interacción con el polielectrolito catiónico mediante fuerzas del tipo electrostática, la cual fue determinada por medio de ITC. Los resultados fueron complementados mediante la determinación de potencial Z de los sistemas modificados, lo cual demostró que no es necesaria una inversión completa de la carga inicial de la superficie de la vesícula para asegurar el recubrimiento de esta. La adición de concentraciones de quitosano mayores a 0,1 mg/mL condujo a la agregación de las vesículas, lo cual fue demostrado mediante Cryo-SEM y DLS. Este efecto fue más significativo para el sistema basado en dimiristoilfosfoglicerol sal de sodio y quitosano, debido a la fuerte atracción electrostática.

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Section: Palavras-chavesunclassified

Caracterización estructural de vesículas modificadas con quitosano

Soto-Cruz

Alvarado-Aguilar

Vega-Baudrit³

et al. 2018

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“…As supported by Madrigal-Carballo et al (2010), the challenge now consists of the incorporation of natural bioactive molecules into dosage forms for preventive and therapeutic applications, knowing that the use of natural materials as drug delivery vehicles arouses interest among scientists, due to numerous advantages like their accessibility (Amin et al 2012). This is why it seemed useful to investigate the behavior of tablets in different surrounding liquids simulating physiologic media, choosing the EC as indicator of release properties of arbutus berry tablets (only data for distilled water are shown here).…”

Section: Resultsmentioning

confidence: 99%

Modeling of the Dissolution Kinetics of Arbutus Wild Berries-Based Tablets as Evaluated by Electric Conductivity

Abbas-Aksil¹,

Salem²

2015

JSM

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“…They are effective carriers for both lipophilic and hydrophilic flavour components, and have been shown to increase bioavailability as compared with oral administration of unencapsulated material [15][16][17][18]. Several liposome-containing food ingredients have already been approved for use or entered trial development [19][20][21][22]. The limitations of liposomes for food encapsulation, however, include a relatively low loading capacity, rapid flavour component release, and instability in storage [23].…”

Section: Introductionmentioning

confidence: 99%

Electrosprayed nanoparticle delivery system for controlled release

Eltayeb

Stride

Edirisinghe

et al. 2016

Materials Science and Engineering: C

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This study utilises an electrohydrodynamic technique to prepare core-shell lipid nanoparticles with a tunable size and high active ingredient loading capacity, encapsulation efficiency and controlled release. Using stearic acid and ethylvanillin as model shell and active ingredients respectively, we identify the processing conditions and ratios of lipid:ethylvanillin required to form nanoparticles. Nanoparticles with a mean size ranging from 60 to 70 nm at the rate of 1.37 × 10 9 nanoparticles per minute were prepared with different lipid:ethylvanillin ratios. The polydispersity index was ≈ 21% and the encapsulation efficiency ≈ 70%. It was found that the rate of ethylvanillin release was a function of the nanoparticle size, and lipid:ethylvanillin ratio. The internal structure of the lipid nanoparticles was studied by transmission electron microscopy which confirmed that the ethylvanillin was encapsulated within a stearic acid shell. Fourier transform infrared spectroscopy analysis indicated that the ethylvanillin had not been affected. Extensive analysis of the release of ethylvanillin was performed using several existing models and a new diffusive release model incorporating a tanh function. The results were consistent with a core-shell structure.

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Biopolymer coating of soybean lecithin liposomes via layer-by-layer self-assembly as novel delivery system for ellagic acid

Cited by 103 publications

References 30 publications

Caracterización estructural de vesículas modificadas con quitosano

Caracterización estructural de vesículas modificadas con quitosano

Modeling of the Dissolution Kinetics of Arbutus Wild Berries-Based Tablets as Evaluated by Electric Conductivity

Electrosprayed nanoparticle delivery system for controlled release

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