Biopolymeric amphiphiles and their assemblies as functional food ingredients and nutraceutical delivery systems

Livney, Y.D.

doi:10.1533/9780857095909.3.252

Cited by 9 publications

(6 citation statements)

References 211 publications

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“…Each domain is composed of two subdomains (A and B). The six subdomains assemble to form a column-shaped structure. − BSA contains three domains specified for metal ion, lipid, and nucleotide binding. , The two main binding sites are respectively located in the hydrophobic cavities of the subdomains IIA and IIIA, namely, site I and site II…”

Section: Introductionmentioning

confidence: 99%

Formation of a Multiligand Complex of Bovine Serum Albumin with Retinol, Resveratrol, and (−)-Epigallocatechin-3-gallate for the Protection of Bioactive Components

Cheng

Chen

et al. 2017

J. Agric. Food Chem.

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Clarification of the interaction mechanisms between proteins and bioactive components is important to develop effective carriers for encapsulation and protection of bioactive components. Bovine serum albumin (BSA), a globular protein in serum and milk, contains multiple sites to bind a variety of low-molecular-weight molecules, forming protein-monoligand complexes. In this study, the interactions of BSA with retinol, resveratrol, and/or (-)-epigallocatechin-3-gallate (EGCG) were investigated by using fluorescence, circular dichroism, and molecular docking techniques. BSA-triligand complexes were successfully formed when added in the sequence of retinol, resveratrol, and EGCG. The stability of these bioactive components was improved in the complexes relative to free ones. The complexes provided a better protective effect on retinol and resveratrol than did BSA-monoligand complexes, in which the presence of EGCG played an important role.

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Section: Introductionmentioning

confidence: 99%

Formation of a Multiligand Complex of Bovine Serum Albumin with Retinol, Resveratrol, and (−)-Epigallocatechin-3-gallate for the Protection of Bioactive Components

Cheng

Chen

et al. 2017

J. Agric. Food Chem.

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“…One of the challenges of food enrichment with such bioactive compounds is related to the poor solubility, in the case of hydrophobic compounds, in food matrices and their instability during digestion and consequent poor bioavailability. These challenges are promoting research efforts to find more effective delivery systems based on natural biopolymers (Livney, 2012). Protein nanohydrogels are promising systems to be used as carriers of bioactive compounds in food products (Martins et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

In vitro digestion of lactoferrin-glycomacropeptide nanohydrogels incorporating bioactive compounds: Effect of a chitosan coating

2018

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The behaviour of lactoferrin (Lf)glycomacropeptide (GMP) nanohydrogels with and without a chitosan coating was evaluated during gastrointestinal digestion. The application of a chitosan coating allowed to reduce the protein degradation from 86% to 76% for Lf and from 71% to 53% for GMP. Protein bioaccessibility results showed that in nanohydrogels with chitosan coating 23% of Lf and 40% of GMP remained intact until absorption. Based on these results, the bioaccessibility of two different bioactive compounds encapsulated in Lf-GMP nanohydrogels with chitosan coating was evaluated during gastrointestinal digestion. Curcumin was used as lipophilic model compound and caffeine as a hydrophilic model compound. Bioaccessibility of curcumin in coated nanohydrogels was 72% while the corresponding value for curcumin in free form only reached 66%. It was also observed that under simulated gastric and intestinal conditions, free curcumin lost around 68% of its antioxidant activity while when incorporated into nanohydrogels only 30% of this activity was lost. Results also showed that the bioaccessibility of caffeine encapsulated in coated nanohydrogels was 63% while caffeine in free form only reached 59%.

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“…The number of available/allowable building blocks for food systems is by far smaller than for pharmaceutical systems, which makes the design and implementation more challenging (and interesting). The topic of biopolymeric amphiphiles and their assemblies as nutraceutical delivery systems, and the physicochemical principles for their self-assembly and co-assembly with bioactives has been recently reviewed [94]. Low molecular weight surfactants based delivery systems like micelles and microemulsions [101], and liposomes [102] have also been reviewed.…”

Section: Points For Further Thought and Discussionmentioning

confidence: 99%

Nanostructured delivery systems in food: latest developments and potential future directions

Livney

2015

Current Opinion in Food Science

140

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Biopolymeric amphiphiles and their assemblies as functional food ingredients and nutraceutical delivery systems

Cited by 9 publications

References 211 publications

Formation of a Multiligand Complex of Bovine Serum Albumin with Retinol, Resveratrol, and (−)-Epigallocatechin-3-gallate for the Protection of Bioactive Components

Formation of a Multiligand Complex of Bovine Serum Albumin with Retinol, Resveratrol, and (−)-Epigallocatechin-3-gallate for the Protection of Bioactive Components

In vitro digestion of lactoferrin-glycomacropeptide nanohydrogels incorporating bioactive compounds: Effect of a chitosan coating

Nanostructured delivery systems in food: latest developments and potential future directions

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