Bioprinting and Tissue Engineering: Recent Advances and Future Perspectives

Seliktar, Dror; Dikovsky, Daniel; Napadensky, Eduardo

doi:10.1002/ijch.201300084

Cited by 42 publications

(22 citation statements)

References 104 publications

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“…3D bioprinting is a layer-by-layer bioadditive approach, which involves cells during the fabrication process and allows the precise simultaneous 3D positioning of multiple cell types 24, 25 . In this regard, Norotte et al 15 used tissue spheroids and printed them sequentially in cylindrical form to build multicellular short stretches of vessels ranging from 0.9 to 2.5 mm in diameter.…”

Section: Introductionmentioning

confidence: 99%

In vitro study of directly bioprinted perfusable vasculature conduits

et al. 2015

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The ability to create three dimensional (3D) thick tissues is still a major tissue engineering challenge. It requires the development of a suitable vascular supply for an efficient media exchange. An integrated vasculature network is particularly needed when building thick functional tissues and/or organs with high metabolic activities, such as the heart, liver and pancreas. In this work, human umbilical vein smooth muscle cells (HUVSMCs) were encapsulated in sodium alginate and printed in the form of vasculature conduits using a coaxial deposition system. Detailed investigations were performed to understand the dehydration, swelling and degradation characteristics of printed conduits. In addition, because perfusional, permeable and mechanical properties are unique characteristics of natural blood vessels, for printed conduits these properties were also explored in this work. The results show that cells encapsulated in conduits had good proliferation activities and that their viability increased during prolonged in vitro culture. Deposition of smooth muscle matrix and collagen was observed around the peripheral and luminal surface in long-term cultured cellular vascular conduit through histology studies.

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Section: Introductionmentioning

confidence: 99%

In vitro study of directly bioprinted perfusable vasculature conduits

et al. 2015

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“…In the former case, scaffolds of complex geometries should be printed using only biocompatible materials. The technology of engineering artificial tissues by directly encapsulating cells as part of the ink (called ‘bioink’) during the printing process is known as bioprinting 63, 64 . While 3D printing, using routine methods for industrial applications, allows a direct use of commercial printers without modifications, bioprinting technologies may not be compatible with commercial printer use and would require custom-built printing devices and bio-compatible ink materials.…”

Section: D Printing Approach In Tissue and Organ Engineeringmentioning

confidence: 99%

From Microscale Devices to 3D Printing

Borovjagin

Ogle

Berry

et al. 2017

Circulation Research

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Current strategies for engineering cardiovascular cells and tissues have yielded a variety of sophisticated tools for studying disease mechanisms, for development of drug therapies, and for fabrication of tissue equivalents that may have application in future clinical use. These efforts are motivated by the need to extend traditional two-dimensional (2D) cell culture systems into 3D to more accurately replicate in vivo cell and tissue function of cardiovascular structures. Developments in microscale devices and bioprinted 3D tissues are beginning to supplant traditional 2D cell cultures and pre-clinical animal studies that have historically been the standard for drug and tissue development. These new approaches lend themselves to patient-specific diagnostics, therapeutics, and tissue regeneration. The emergence of these technologies also carries technical challenges to be met before traditional cell culture and animal testing become obsolete. Successful development and validation of 3D human tissue constructs will provide powerful new paradigms for more cost effective and timely translation of cardiovascular tissue equivalents.

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“…This technology represents the bottom up process in which biological materials and/or cells are patterned and assembled into computer-designed two-dimensional (2D) or three-dimensional (3D) organizations [1] . 3D bioprinting brings new approaches in addressing traditional tissue engineering issues such as the lack of a controlled and functional histoarchitecture [2][3][4][5] . For example, patient-specific bone grafts with well-defined shapes and internal structures can be constructed using the 3D bioprinting and medical imaging techniques [6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

Smart hydrogels for 3D bioprinting

Wang¹,

Lee²,

Yeong³

2024

IJB

149

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Hydrogels are 3D networks that have a high water content. They have been widely used as cell carriers and scaffolds in tissue engineering due to their structural similarities to the natural extracellular matrix. Among these, "Smart" hydrogels refer to a group of hydrogels that is responsive to various external stimuli such as pH, temperature, light, electric, and magnetic field. Combining the potential of 3D printing and smart hydrogels is an exciting new paradigm in the fabrication of a functional 3D tissue. In this article, we provide a state-of-the-art review on smart hydrogels and bioprinting. We identify the critical material properties needed for the most commonly used bioprinting techniques, namely extrusion-based, inkjet-based, and laser-based techniques. The latest progress in different smart hydrogel systems and their applications in bioprinting are presented. The challenges of printing these hydrogel systems are also highlighted. Lastly, we present the potentials and the future perspectives of smart hydrogels in 3D bioprinting.

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Bioprinting and Tissue Engineering: Recent Advances and Future Perspectives

Cited by 42 publications

References 104 publications

In vitro study of directly bioprinted perfusable vasculature conduits

In vitro study of directly bioprinted perfusable vasculature conduits

From Microscale Devices to 3D Printing

Smart hydrogels for 3D bioprinting

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