2020
DOI: 10.1021/acs.chemrev.9b00789
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Bioprinting: From Tissue and Organ Development to in Vitro Models

Abstract: Bioprinting techniques have been flourishing in the field of biofabrication with pronounced and exponential developments in the past years. Novel biomaterial inks used for the formation of bioinks have been developed, allowing the manufacturing of in vitro models and implants tested preclinically with a certain degree of success. Furthermore, incredible advances in cell biology, namely, in pluripotent stem cells, have also contributed to the latest milestones where more relevant tissues … Show more

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Cited by 235 publications
(175 citation statements)
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“…Special benefits of in situ gelling systems are that they can exactly fill the defects in the host tissue and be loaded with drugs and cells [19]. In addition, such type of hydrogel precursors are also useful as inks for 3D bioprinting [20]. Chemical cross-linked synthetic hydrogels are usually hydrolytic and enzymatic resistant, which might be unfavorable for applications in tissue engineering.…”
Section: Of 18mentioning
confidence: 99%
“…Special benefits of in situ gelling systems are that they can exactly fill the defects in the host tissue and be loaded with drugs and cells [19]. In addition, such type of hydrogel precursors are also useful as inks for 3D bioprinting [20]. Chemical cross-linked synthetic hydrogels are usually hydrolytic and enzymatic resistant, which might be unfavorable for applications in tissue engineering.…”
Section: Of 18mentioning
confidence: 99%
“…[17][18][19][20][21][22][23][24][25][26][27] The technique most commonly used is extrusion-based bioprinting, whereby a socalled bioink is extruded through a nozzle in a layer-by-layer fashion via mechanical pressure, thus creating 3D constructs in a preprogrammed design. [17][18][19][20][21] Despite the great flexibility of this technique, major limitations are related to low resolution, cell deformation induced by shear stress, and limited bioink selection. 28 Laser-assisted printing represents another 3D bioprinting technique that fabricates precise structures via a layer-by-layer technique, resulting in high printing resolutions.…”
Section: D Bioprintingmentioning
confidence: 99%
“…31 Digital light processing, a variant of stereolithography, has been used to print high resolution constructs in a layer-by-layer fashion by using UV light to cross-link photopolymerizable polymers. 17,32 Major drawbacks of this technique are the lack of biocompatible and biodegradable materials and the harsh nature of UV radiation necessary for the cross-linking. 33 Piezo-assisted bioprinting fabricates constructs through accurate ejection of cells into droplets to form highly organized patterns.…”
Section: D Bioprintingmentioning
confidence: 99%
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“…The complex interplay between the varied components, including mechanical dynamics, can greatly influence the form and function of a fabricated tissue. Bioprinting is a rapidly progressing field, enabling the fabrication of a variety of biomedical-related constructs and structures, including tissue therapeutics (Datta et al, 2017;Xiang et al, 2020), in vitro tissue models and phantoms (Mao et al, 2020;Mota et al, 2020;Sasikumar et al, 2020), and biomedical devices (Bedell et al, 2020). Furthermore, bioprinting, as a type of additive manufacturing, is amenable to scaled up tissue fabrication and manufacturing, an important consideration as clinical use of fabricated tissues increases (Wu et al, 2017;Skylar-Scott et al, 2019;Castilho et al, 2020).…”
Section: Introductionmentioning
confidence: 99%