Bioprinting of Organ-on-Chip Systems: A Literature Review from a Manufacturing Perspective

Thakare, Ketan; Jerpseth, Laura; Pei, Zhijian; Elwany, Alaa; Quek, Francis; Qin, Hongmin

doi:10.3390/jmmp5030091

Cited by 19 publications

(14 citation statements)

References 80 publications

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“…Recently the concept of bioprinting has been used by many researchers which could lead to more cost-efficient fabrication of the OoC. Soft-lithography and photolithography, cost, time and design improvements are all more advantageous if bioprinting is used ( Carvalho et al, 2021 ; Thakare et al, 2021 ). More importantly the different paths that are opened can reach to the automation of medical procedures and the elimination of mistreatment.…”

Section: Discussionmentioning

confidence: 99%

Organ-On-A-Chip: A Survey of Technical Results and Problems

Danku

Dulf

Braicu

et al. 2022

Front. Bioeng. Biotechnol.

103

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Organ-on-a-chip (OoC), also known as micro physiological systems or “tissue chips” have attracted substantial interest in recent years due to their numerous applications, especially in precision medicine, drug development and screening. Organ-on-a-chip devices can replicate key aspects of human physiology, providing insights into the studied organ function and disease pathophysiology. Moreover, these can accurately be used in drug discovery for personalized medicine. These devices present useful substitutes to traditional preclinical cell culture methods and can reduce the use of in vivo animal studies. In the last few years OoC design technology has seen dramatic advances, leading to a wide range of biomedical applications. These advances have also revealed not only new challenges but also new opportunities. There is a need for multidisciplinary knowledge from the biomedical and engineering fields to understand and realize OoCs. The present review provides a snapshot of this fast-evolving technology, discusses current applications and highlights advantages and disadvantages for biomedical approaches.

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Section: Discussionmentioning

confidence: 99%

Organ-On-A-Chip: A Survey of Technical Results and Problems

Danku

Dulf

Braicu

et al. 2022

Front. Bioeng. Biotechnol.

103

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“…[60,61] Prerequisite requirements for bioinks include biocompatibility (not adversely affecting cell functionality), biomimicry (mimic the ECM characteristics), shear-thinning behavior (nonlinear rise in viscosity when stressed, which is a sign of printable materials), structural constancy, and acceptable mechanical properties. [62] In many 3D bioprinting methods, highly viscous bioinks, typically cell-laden hydrogels, solidify using external factors such as ions and temperature. A negative consequence is that cells experience shear stress during the printing procedure in these systems, and their functionality and viability can be affected.…”

Section: D Printing For the Biofabrication Of In Vitro Systemsmentioning

confidence: 99%

Advanced Materials and Sensors for Microphysiological Systems: Focus on Electronic and Electrooptical Interfaces

2022

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Advanced in vitro cell culture systems or microphysiological systems (MPSs), including microfluidic organ‐on‐a‐chip (OoC), are breakthrough technologies in biomedicine. These systems recapitulate features of human tissues outside of the body. They are increasingly being used to study the functionality of different organs for applications such as drug evolutions, disease modeling, and precision medicine. Currently, developers and endpoint users of these in vitro models promote how they can replace animal models or even be a better ethically neutral and humanized alternative to study pathology, physiology, and pharmacology. Although reported models show a remarkable physiological structure and function compared to the conventional 2D cell culture, they are almost exclusively based on standard passive polymers or glass with none or minimal real‐time stimuli and readout capacity. The next technology leap in reproducing in vivo‐like functionality and real‐time monitoring of tissue function could be realized with advanced functional materials and devices. This review describes the currently reported electronic and optical advanced materials for sensing and stimulation of MPS models. In addition, an overview of multi‐sensing for Body‐on‐Chip platforms is given. Finally, one gives the perspective on how advanced functional materials could be integrated into in vitro systems to precisely mimic human physiology.

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“…By transferring the pattern from the stamp to other polymer structures, complex 3D microchannels may be formed. A closed-circuit channel is created and is then sealed with a glass slide[ 113 - 115 ]. Replica molding uses a photolithographically patterned silicon mold, PDMS pouring, and heat curing to build a device that is affixed to a flat, smooth surface, such as glass, to create a microfluidic chip with microchannels.…”

Section: Tumor-on-a-chip Platformsmentioning

confidence: 99%

Bioprinting and its Use in Tumor-On-A-Chip Technology for Cancer Drug Screening: A Review

Fang¹,

Liu²,

Qiu³

et al. 2022

IJB

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The rising global incidence of cancer and high attrition rates of anticancer drugs make it imperative to design novel screening platforms to increase the success rate of chemotherapeutic agents. Advances in cell culture models from two-dimensional to three-dimensional platforms, along with microfluidics, have resulted in the creation of tumor-on-a-chip technology, which enables high-throughput molecular screening and helps to simulate the dynamic tumor microenvironment. Furthermore, advancements in bioprinting have allowed the structural and physiological aspects of the tumor to be recreated accurately and help to mimic cell-cell interactions and cell-extracellular matrix. This paper provides a comprehensive review of three-dimensional bioprinting to fabricate a tumor-on-a-chip platform to advance the discovery and screening of anticancer agents and provides a perspective on the challenges and future directions associated with the adoption of this technology to advance cancer research.

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Bioprinting of Organ-on-Chip Systems: A Literature Review from a Manufacturing Perspective

Cited by 19 publications

References 80 publications

Organ-On-A-Chip: A Survey of Technical Results and Problems

Organ-On-A-Chip: A Survey of Technical Results and Problems

Advanced Materials and Sensors for Microphysiological Systems: Focus on Electronic and Electrooptical Interfaces

Bioprinting and its Use in Tumor-On-A-Chip Technology for Cancer Drug Screening: A Review

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