Bioprinting of Stem Cell Spheroids Followed by Post‐Printing Chondrogenic Differentiation for Cartilage Tissue Engineering (Adv. Healthcare Mater. 19/2023)

Decarli, Monize Caiado; Seijas‐Gamardo, Adrián; Morgan, Francis L. C.; Wieringa, Paul; Baker, Matthew B.; Silva, Jorge Vicente L.; Moraes, Ângela Maria; Moroni, Lorenzo; Mota, Carlos

doi:10.1002/adhm.202370107

Cited by 1 publication

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“…[ 45,57,96 ] Different bioprinting modalities for processing spheroid‐containing inks have been reported in the literature, including extrusion‐based, Kenzan, and aspiration‐assisted bioprinting. [ 45,46,97 ] For instance, leveraging on aspiration‐assisted bioprinting, researchers demonstrated to successfully pick spheroids assembled from multiple cell types, including, HUVECs and MSCs, into place them in an alginate‐based sacrificial gel, acting as supporting bath. [ 46 ] Resorting to this methodology, spheroids were successfully combined into multiple cell‐rich constructs, including rings, pyramids, and diamond‐shaped architectures, achieving a positional accuracy of ≈15% relative to spheroid size.…”

Section: Bioprinting Cell‐rich Living Inksmentioning

confidence: 99%

Advances in Cell‐Rich Inks for Biofabricating Living Architectures

Almeida‐Pinto,

Moura,

Gaspar

et al. 2024

Advanced Materials

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Advancing biofabrication towards manufacturing living constructs with well‐defined architectures and increasingly biologically relevant cell densities is highly desired to mimic the biofunctionality of native human tissues. The formulation of tissue‐like, cell‐dense inks for biofabrication remains, however, challenging at various levels of the bioprinting process. Promising advances have been made towards this goal, and relatively high cell densities have been achieved, surpassing the limited cell densities of conventional platforms, pushing the current boundaries a step closer to achieving tissue‐like cell densities. On this focus, herein we discuss the overarching challenges in the bioprocessing of cell‐rich living inks into clinically‐grade engineered tissues, as well as highlight the most recent advances in cell‐rich living ink formulations and their processing technologies. Additionally, an overview of the foreseen developments in the field is provided and critically discussed.This article is protected by copyright. All rights reserved

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Section: Bioprinting Cell‐rich Living Inksmentioning

confidence: 99%