Bioprocess Development for Large Scale Production of Anticancer Exo-Polysaccharide by Pleurotus ostreatus in Submerged Culture

El‐Enshasy, Hesham Ali; Daba, A. S.; El-Demella, M.; Ibrahim, A.; Sayed, Salah El; El-Badry, I.

doi:10.3923/jas.2010.2523.2529

Cited by 24 publications

(14 citation statements)

References 17 publications

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“…The advantage of this feeding strategy was to overcome the negative impact of overfeeding and underfeeding on cell growth and product formation (Lee et al 1999). Carbon source feeding using DO and outgas analysis online data (for oxygen consumption or carbon dioxide production) was also proven as suitable fed-batch approach to prevent carbon source limitation and increase polysaccharide production by Pleurotus ostreatus (El Enshasy et al 2010) and in DNA vaccine production by the recombinant Escherichia coli (Chen et al 1997). However, in addition to the advantages of this approach to prevent carbon source limitation and substrate overflow, this cultivation strategy also helped to control the DO value at certain levels during the cultivation.…”

Section: Fed-batch Cultivation Of S Rimosusmentioning

confidence: 99%

Development of Fed-Batch Cultivation Strategy for Efficient Oxytetracycline Production by Streptomyces rimosus at Semi-Industrial Scale

Elsayed

Omar

El‐Enshasy

2015

Braz. arch. biol. technol.

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Section: Fed-batch Cultivation Of S Rimosusmentioning

confidence: 99%

Development of Fed-Batch Cultivation Strategy for Efficient Oxytetracycline Production by Streptomyces rimosus at Semi-Industrial Scale

Elsayed

Omar

El‐Enshasy

2015

Braz. arch. biol. technol.

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“…They are also rich in many bioactive metabolites of high medicinal value such as lectins, polysaccharides, phenolics and polyphenolics, terpenoids, ergosterols, and volatile organic compounds [ 19 – 21 ]. Mushroom extracts have therefore been used medicinally in immunomodulator [ 22 – 25 ], antitumor/anticancer [ 26 – 30 ], antibacterial and antiviral [ 31 – 33 ], antioxidant [ 34 – 37 ], and antihypoglycaemic [ 38 – 40 ] applications and as active medicines in the prevention of cardiovascular diseases through their action as antiatherosclerotic agents [ 41 ]. In addition, many compounds of highly diversified chemical structures with anti-inflammatory activities have been isolated and purified from different types of mushrooms.…”

Section: Introductionmentioning

confidence: 99%

Mushrooms: A Potential Natural Source of Anti-Inflammatory Compounds for Medical Applications

Elsayed

Enshasy

Wadaan

et al. 2014

Mediators of Inflammation

170

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For centuries, macrofungi have been used as food and medicine in different parts of the world. This is mainly attributed to their nutritional value as a potential source of carbohydrates, proteins, amino acids, and minerals. In addition, they also include many bioactive metabolites which make mushrooms and truffles common components in folk medicine, especially in Africa, the Middle East, China, and Japan. The reported medicinal effects of mushrooms include anti-inflammatory effects, with anti-inflammatory compounds of mushrooms comprising a highly diversified group in terms of their chemical structure. They include polysaccharides, terpenoids, phenolic compounds, and many other low molecular weight molecules. The aims of this review are to report the different types of bioactive metabolites and their relevant producers, as well as the different mechanisms of action of mushroom compounds as potent anti-inflammatory agents.

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“…For many years mushroom cultivation is usually carried out using green house. However, nowadays beside solid state cultivation system using lignocellulosic biomass residues, cultivations were also successfully carried out in full submerged cultivation system under controlled sterile conditions to reduce the production time, increase in both volumetric and specific bioactive metabolites production, and to reduce the risk of contamination during mushroom cultivation [10,11].…”

Section: Introductionmentioning

confidence: 99%

The Edible Mushroom Pleurotus spp.: I. Biodiversity and Nutritional Values

Maftoun

Johari

Soltani

et al. 2015

Int. J. Biotech. Well. Indus.

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Mushrooms are macrofungi with numerous varieties and widely known as food and medicine in many ancient cultures. They are considered as potential source of many essential nutrients as well as therapeutic bioactive compounds and thus became one of the main components in Traditional Chinese Medicine (TCM) and in Japanese herbal medicine since more than two thousand years. The genus Pleurotus (widely known as oyster mushroom) is fast growing fungus belongs to basidiomycota group and considered as one of the famous species with many health benefits. Nowadays, seventy species of this genus has been discovered, but solely a few of them such as P. florida, P. sajor-caju and P. ostreatus are available in the market. The rich nutrients such as proteins, fibers, carbohydrates, minerals, vitamins, and lipids present this mushroom as famous healthy food. Furthermore, Bioactive compounds such as polysaccharides, proteins and nucleic acid are extracted from various species of Pleurotus tends the researcher to investigate more on this beneficial genus. This work is focused on reviewing the recent work published in the biodiversity and nutritional content of Pleurotus spp.

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Bioprocess Development for Large Scale Production of Anticancer Exo-Polysaccharide by Pleurotus ostreatus in Submerged Culture

Cited by 24 publications

References 17 publications

Development of Fed-Batch Cultivation Strategy for Efficient Oxytetracycline Production by Streptomyces rimosus at Semi-Industrial Scale

Development of Fed-Batch Cultivation Strategy for Efficient Oxytetracycline Production by Streptomyces rimosus at Semi-Industrial Scale

Mushrooms: A Potential Natural Source of Anti-Inflammatory Compounds for Medical Applications

The Edible Mushroom Pleurotus spp.: I. Biodiversity and Nutritional Values

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