Bioproduction of 2-Phenylethanol in a Biphasic Ionic Liquid Aqueous System

Sendovski, M.; Nir, N.; Fishman, Ayelet

doi:10.1021/jf903879x

Cited by 96 publications

(63 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In general, the toxicity of ILs appears to be directly proportional to the length of the alkyl chain as well as the number of alkyl groups substituted on the cation (Pernak et al 2003;Romero et al 2008;Sendovski et al 2010).…”

Section: Approaches To Manage Il Toxicitymentioning

confidence: 99%

“…The toxicity of certain ILs can also inhibit enzymatic activity of microorganisms due to accumulation in cell membranes (Matsumoto et al 2004;Pham et al 2010;Romero et al 2008). Some ILs also have been shown to inhibit cell growth and cell viability for various microorganisms (Ganske and Bornscheuer 2006;Jing et al 2014;Pernak et al 2003;Pfruender et al 2006;Sendovski et al 2010). Many challenges associated with IL toxicity must be overcome before ILs can be utilized at the commercial scale (Egorova and Ananikov 2014).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ionic liquid-tolerant microorganisms and microbial communities for lignocellulose conversion to bioproducts

Simmons

Singer

et al. 2016

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

Chemical and physical pretreatment of biomass is a critical step in the conversion of lignocellulose to biofuels and bioproducts. Ionic liquid (IL) pretreatment has attracted significant attention due to the unique ability of certain ILs to solubilize some or all components of the plant cell wall. However, these ILs not only inhibit enzyme activities, but also the growth and productivity of microorganisms used in downstream hydrolysis and fermentation processes.While pretreated biomass can be washed to remove residual IL and reduce inhibition, extensive washing is costly and not feasible in large-scale processes. IL tolerant microorganisms and microbial communities have been discovered from environmental samples and studies begun to elucidate mechanisms of IL tolerance. The discovery of IL tolerance in environmental microbial communities and individual microbes has lead to the proposal of molecular mechanisms of resistance. In this article, we review recent progress on discovering IL tolerant microorganisms, identifying metabolic pathways and mechanisms of tolerance, and engineering microorganisms for IL tolerance. Research in these areas will yield new approaches to overcome inhibition in lignocellulosic biomass bioconversion processes and increase opportunities for the use of ILs in biomass pretreatment.

show abstract

Section: Approaches To Manage Il Toxicitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ionic liquid-tolerant microorganisms and microbial communities for lignocellulose conversion to bioproducts

Simmons

Singer

et al. 2016

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

show abstract

“…The wide variety of flavour compounds amenable of microbial production permits the application of various separation methods. For example, organic solvent extraction [14], ionic liquid extraction [15], solid-liquid sorption [16], supercritical CO 2 extraction [17], immobilized solvent extraction [18], and pervaporation [19], have been employed to remove 2-phenylethanol from the medium following its production. Although some of these techniques are more efficient, they have some shortcomings.…”

Section: Introductionmentioning

confidence: 99%

Lindnera saturnus Kullanılarak Hücresel Biyodönüşüm Yolu ile Fuzel Yağından Muz Aroması Eldesi

Yılmaztekin¹,

Tay²

2016

Çukurova Üniversitesi Mühendislik-Mimarlık Fakültesi Dergisi

View full text Add to dashboard Cite

An efficient biotransformation of isoamyl alcohol obtained from fusel oil to isoamyl acetate in a molasses based medium via in situ product removal (ISPR) with macroporous adsorption resin was carried out with Lindnera saturnus. Nine types of macroporous adsorption resins with different polarities and surface areas were tested with synthetic medium and then in batch and fed-batch cultivations. H103 resin had the best adsorption capacity because of its large and nonpolar surface areas. The isoamyl acetate concentration was increased with 42 and 30 folds in batch and fed-batch cultivations, respectively, compared to the biotransformations without addition of adsorbent resin. When 1 g H103 resin (wet w/v) was added to 50 mL of the biotransformation medium, the total isoamyl acetate concentration achieved was 1.9 g/L, of which 123 mg/L remained in the aqueous phase and 1787 mg/L was adsorbed onto the resin, within 120 h in fed-batch system. This was the highest isoamyl acetate yield by biotransformation until now and was remarkable for making the process more feasible for industrial application.

show abstract

“…According to ZHU et al (2011) it occurs naturally in essential oils of flowers as hyacinth, jasmine, lilies and daffodils, however, concentrations are too low to justify extraction (SENDOVSKI et al, 2010), with the exception of rose oil that contains up to 60% PE. High percentages of FE can be obtained by steam drag distillation and solvent extraction.…”

Section: Introductionmentioning

confidence: 99%

“…BOONNOP et al (2009) used S. cerevisiae to increase by-products nutritional value of cassava by fermentation processes. The yeast was used in PE production studies for present phenylpyruvate pathway which allows obtaining this type of alcohol (OLIVEIRA et al, 2013;MEI et al, 2009;SENDOVSKI et al, 2010). …”

Section: Introductionmentioning

confidence: 99%

Production of natural aroma by yeast in wastewater of cassava starch industry

et al. 2015

View full text Add to dashboard Cite

2-Phenylethanol (PE) is an aromatic alcohol with a characteristic odor of roses, widely used in food industry to modify certain aroma compositions in formulations with fruit, jam, pudding, and chewing gums, and also in cosmetic and fragrance industry. This compound occurs naturally in low concentrations in some essential oils from flowers and plants. An alternative to plants extraction are biotechnological processes. This study evaluated 2-phenylethanol's production in cultivation of Saccharomyces cerevisiae in cassava wastewater originated from starch industry. The substrate was supplemented with glucose and L-phenylalanine in order to obtain higher 2-phenylethanol concentrations and better efficiency in glucose/2-phenylethanol conversion. It was performed using Rotatable Center Composite Design and response surface analysis. Cultures were performed under aerobic conditions in a batch system in Erlenmeyer flasks containing 50 mL of medium in shaker at 150 rpm and 24 ± 1 ºC. The highest PE values were obtained with supplementation of 20.0 g.L -1 of glucose and 5.5 g.L -1 of L-phenylalanine, which has been experimentally validated, obtaining a PE production of 1.33 g.L -1 and PE/glucose yield factor of 0.070 g.g -1 , equivalent to 74.3 and 89.7% of desirability values according to the validated model.

show abstract

Bioproduction of 2-Phenylethanol in a Biphasic Ionic Liquid Aqueous System

Cited by 96 publications

References 24 publications

Ionic liquid-tolerant microorganisms and microbial communities for lignocellulose conversion to bioproducts

Ionic liquid-tolerant microorganisms and microbial communities for lignocellulose conversion to bioproducts

Lindnera saturnus Kullanılarak Hücresel Biyodönüşüm Yolu ile Fuzel Yağından Muz Aroması Eldesi

Production of natural aroma by yeast in wastewater of cassava starch industry

Contact Info

Product

Resources

About