Bioprospecting on invasive plant species to prevent seed dispersal

Guzzetti, Lorenzo; Galimberti, Andrea; Bruni, Ilaria; Magoni, Chiara; Ferri, Maura; Tassoni, Annalisa; Sangiovanni, Enrico; Dell’Agli, Mario; Labra, Massimo

doi:10.1038/s41598-017-14183-5

Cited by 12 publications

(8 citation statements)

References 64 publications

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“…Toxicity is an important factor to be investigated as part of prospecting for new active substances [23]. Concentration-response tests performed with human cells have been increasingly used in the screening of new active substances [24–26].…”

Section: Discussionmentioning

confidence: 99%

Screening and Antifungal Activity of a β-Carboline Derivative against Cryptococcus neoformans and C. gattii

Cruz

Lima

Silva

et al. 2019

International Journal of Microbiology

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Background Cryptococcosis is a fungal disease of bad prognosis due to its pathogenicity and the toxicity of the drugs used for its treatment. The aim of this study was to investigate the medicinal potential of carbazole and β-carboline alkaloids and derivatives against Cryptococcus neoformans and C. gattii. Methods MICs were established in accordance with the recommendations of the Clinical and Laboratory Standards Institute for alkaloids and derivatives against C. neoformans and C. gattii genotypes VNI and VGI, respectively. A single active compound was further evaluated against C. neoformans genotypes VNII, VNIII, and VNIV, C. gattii genotypes VGI, VGIII, and VGIV, Candida albicans ATCC 36232, for cytotoxicity against the MRC-5 lineage of human fibroblasts and for effects on fungal cells (cell wall, ergosterol, and leakage of nucleic acids). Results Screening of 11 compounds revealed 8-nitroharmane as a significant inhibitor (MIC 40 μg/mL) of several C. neoformans and C. gattii genotypes. It was not toxic to fibroblasts (IC50 > 50 µg/mL) nor did it alter fungal cell walls or the concentration of ergosterol in C. albicans or C. neoformans. It increased leakage of substances that absorb at 260 nm. Conclusions The synthetic β-carboline 8-nitroharmane significantly inhibits pathogenic Cryptococcus species and is interesting as a lead compound towards new therapy for Cryptococcus infections.

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Section: Discussionmentioning

confidence: 99%

Screening and Antifungal Activity of a β-Carboline Derivative against Cryptococcus neoformans and C. gattii

Cruz

Lima

Silva

et al. 2019

International Journal of Microbiology

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“…Social consequences mainly affect human health and safety, as well as the quality of life in general (Lykholat et al, 2016); cultural heritage and other aspects of the social order (Marbuah et al, 2014). Thus, alien species damage agriculture (Pratt et al, 2017) and forestry (Borisova, 2016), negatively transform the functioning of urban ecosystems and adversely affect human health by becoming a source of allergies and other diseases (Guzzetti et al, 2017;Pismarkina & Silaeva, 2018).…”

Section: Introductionmentioning

confidence: 99%

Modeling the invasiveness of Ulmus pumila in urban ecosystems in conditions of climate change

Lykholat

Хромых

Дідур

et al. 2018

Regul. Mech. Biosyst.

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Climatic change can influence the boundaries of the natural and alien plant species distribution. Fluctuations in air temperature, relative humidity and other factors can become a stimulus to initiation and / or intensification of the invasive nature of some adventive plant species, especially in areas with a high degree of anthropogenic transformation. This paper presents an analysis of the current state and a forecast of the invasiveness of the alien species Ulmus pumila L. (Asiatic elm) in the Northern Steppe Dnieper under conditions of climatic change. Two local U. pumila populations consisting of young different age trees were found during a route survey in the territory of the large industrial city Dnipro (48°28′00″ N, 35°01′05″ E) in its left-bank and right-bank parts.The seed origin of both local populations of Asiatic elm is confirmed by the fact that the young plants were spaced at a distance of 50 to 120 m from adult trees, which could potentially be parent plants. Both the left-bank and right-bank populations of U. pumila were located on abandoned construction sites, where there were numerous reinforced concrete slabs, piles and abundant construction debris. In both U. pumila local populations, 100 different-aged trees were randomly selected throughout the site, and their age and the morphometric parameters were measured to simulate the development process of the detected populations, provided the current trends of climate change continue. Analytical dependence of the number of trees in the left-bank local U. pumila population on development time was described by a polynomial model with a determination coefficient of 98.3%. The graphic representation of this model had a sinusoidal character, and a similar dynamic of left-bank population growth in the subsequent years was suggested. The dynamic of the number of trees in the right-bank local Asiatic elm population was described by an exponential model with a determination coefficient of 84.4%, and its graphical representation was exponential. According to the forecast, by 2020, the number of plants in the right-bank local population of U. pumila can increase 4-fold in comparison with 2015 while maintaining the current dynamic of population development. Thus, the created mathematical models adequately described the dynamics of development of both local populations during the last 15 years and predicted their subsequent intensive growth, confirming the initiation and intensification of the invasive nature of the alien species U. pumila by climatic change in the Steppe Dnieper.

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“…As a result, numerous reports are dedicated to the study of useful properties of invasive plants, among which different biological activities. The antioxidant activity of these plants demonstrated valuable results comparing with widely used species (Guzzetti, et al, 2017;Sari, et al, 2018;Maema, Potgieter and Samie, 2019). Several studies showed that the content of polyphenol compounds of invasive plants had higher values than native (Kim and Lee, 2011).…”

Section: Resultsmentioning

confidence: 99%

Phenolic content and antioxidant activity of Echinocystis lobata (Mich.) Torr. ET Gray (Cucurbitaceae)

Vinogradova

Shelepova

Vergun³

et al. 2021

Potr. S. J. F. Sci.

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Echinocystis lobata (Mich.) Torr. et Gray extracts were investigated for their bioactive compounds and their potential for natural antioxidant properties. In vitro antioxidant activity of methanol, ethanol, and water extracts were evaluated by 1,1-diphenyl-picrylhydrazyl (DPPH) radical scavenging activity. Total phenolic content (TPC) and total flavonoid content (TFC) of fruits and seeds were determined. TPC is a fairly constant value and varies weakly both among the different organs of Echinocystis lobata and among the geographical locations of the populations studied. Like other invasive species, Echinocystis lobata is superior to many other plants in terms of the total amount of flavonoids contained in its fruits and seeds. The dried fruits contain more flavonoids than the seeds. Seeds from Slovak populations have higher flavonoid content than those from Russian populations. The results demonstrated that Echinocystis lobata can be a good source of natural antioxidants and have a great potential for commercialization, especially in the pharmaceutical industry.

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Bioprospecting on invasive plant species to prevent seed dispersal

Cited by 12 publications

References 64 publications

Screening and Antifungal Activity of a β-Carboline Derivative against Cryptococcus neoformans and C. gattii

Screening and Antifungal Activity of a β-Carboline Derivative against Cryptococcus neoformans and C. gattii

Modeling the invasiveness of Ulmus pumila in urban ecosystems in conditions of climate change

Phenolic content and antioxidant activity of Echinocystis lobata (Mich.) Torr. ET Gray (Cucurbitaceae)

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