Bioprospection of Potential Trypanocidal Drugs

Muschietti, Liliana; Sülsen, Valeria P.; Martino, Virginia

doi:10.1016/b978-0-444-62615-8.00009-6

Studies in Natural Products Chemistry

2013

DOI: 10.1016/b978-0-444-62615-8.00009-6

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Bioprospection of Potential Trypanocidal Drugs

Liliana Muschietti¹,

Valeria P. Sülsen²,

Virginia Martino³

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Cited by 4 publications

(1 citation statement)

References 191 publications

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“…Chagas disease is particularly endemic in El Salvador compared to other Latin American nations, with approximately 39% of its population facing the risk of infection . However, El Salvador possesses abundant plant resources, many of which are utilized in traditional medicine practices . Building upon prior efforts to find alternative treatments for Chagas disease, our focus shifted to exploring lignans present in the extracts of Peperomia pseudopereskiifolia .…”

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confidence: 99%

Anti-trypanosomal Lignans Isolated from Salvadoran Peperomia pseudopereskiifolia

Castillo,

Uekusa,

Nishimura

et al. 2024

J. Nat. Prod.

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A search for anti-trypanosomal natural compounds from plants collected in El Salvador, a country particularly endemic for Chagas disease, resulted in the isolation of five lignan-type compounds (1−5) from Peperomia pseudopereskiifolia. The lignan derivatives 1, 2, and 4 are new. Their absolute configuration was determined by chemical derivatization. Compounds 1, 5, 6, and 8 exhibited antitrypanosomal activity against the amastigote form of T. cruzi comparable to that of the existing drug benznidazole.

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mentioning

confidence: 99%

Anti-trypanosomal Lignans Isolated from Salvadoran Peperomia pseudopereskiifolia

Castillo,

Uekusa,

Nishimura

et al. 2024

J. Nat. Prod.

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Anti-Trichomonas vaginalis activity of nano Micana cordifolia and Metronidazole: an in vitro study

Vazini

2017

J Parasit Dis

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is a flagellate parasite living in the genital tract and it is accounted as a sexually transmitted disease. The clinical symptoms vary from the asymptomatic to the severe form which is usually associated with the irritation, itching and infertility in some severe cases. Many drugs have been applied to treat this disease and Metronidazole is the gold standard for treatment; however, it has also detected that this medicine has many side-effects which it has been motivated the researchers to find an appropriate alternative for this medicine. One of the treatment options is the use of the herbal medicines and natural compounds. Thus, the aim of this study was to compare the in vitro anti- activity of nano-emulsion of and Metronidazole. In this study, was isolated from the clinical samples and were cultured on a modified Dorsate medium. The nano-emulsion of was prepared by heating technique. The effect of nano-emulsion of was separately investigated on the at the times of 12, 24 and 72 h and the obtained data were analyzed by the Spss 20 using the ANOVA test. The results indicated that the concentration of 100 ppm of nano-emulsion at the times of 12, 24 and 72 h has the anti- activity of 44 ± 1.66, 37 ± 1 and 25 ± 2, respectively. It is also observed that the concentration of 500 ppm of the extract has the best effect and was able to eliminate the 85% of . Furthermore, the anti- activity of nano was observed to be 100% in the concentrations of 1000 ppm. It can be concluded, based on the results, that the nano has acceptable efficacy on the elimination of and it can be a suitable alternative for Metronidazole after implementation of complementary tests on laboratory animals and human cells.

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Antiproliferative effect and ultrastructural alterations induced by 5- O -methylembelin on Trypanosoma cruzi

Spina

Lozano²,

Barrera

et al. 2018

Phytomedicine

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Bioprospection of Potential Trypanocidal Drugs

Cited by 4 publications

References 191 publications

Anti-trypanosomal Lignans Isolated from Salvadoran Peperomia pseudopereskiifolia

Anti-trypanosomal Lignans Isolated from Salvadoran Peperomia pseudopereskiifolia

Anti-Trichomonas vaginalis activity of nano Micana cordifolia and Metronidazole: an in vitro study

Antiproliferative effect and ultrastructural alterations induced by 5- O -methylembelin on Trypanosoma cruzi

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