Biópsia Estereotáxica

No differential effects of subthalamic nucleus vs. globus pallidus deep brain stimulation in Parkinson’s disease: Speech acoustic and perceptual findings

“…Some research opposes the preference for STN over GPI in PD patients, as there is evidence of equivalent improvements in motor symptoms and some potential benefits of GPI-DBS, such as improved dyskinesia control that allows for greater flexibility in dosing parameters without risking medication-induced dyskinesia ( Vitek, 2003 ). In theory, the larger size and lower density of functional circuitry in the GPI may also reduce risk of unintentional current spread to non-target functional circuits ( Zimpel et al, 2023 ). No comparison studies have shown significant differences in stimulation-induced motor side effects between the two targets, although there is evidence that GPI-DBS results in slightly better neurocognitive outcomes ( Combs et al, 2015 , Odekerken et al, 2013 , Okun et al, 2009 ).…”