Biopsy assessment of fifty hearts during transplantation

Darracott-Cankovic, Sally; Wheeldon, D.; Cory-Pearce, R.; Wallwork, J.; English, T. A. H.

doi:10.1016/s0022-5223(19)36480-3

Cited by 24 publications

(1 citation statement)

References 26 publications

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“…UW solution is less frequently used for preserving thoracic organs [6]. Hearts can be preserved with St Thomas's solution [7], HTK [8] or Euro Collins solution [9], and lungs with Collins solution or Papworth solution, a homemade preparation containing donor blood [10]. Thus, two or even three different solutions may be used to preserve thoracic and abdominal organs during a single procurement, increasing both the complexity and the cost of the procedure.…”

Section: Introductionmentioning

confidence: 95%

A single solution for multiple organ procurement and preservation

et al. 2005

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Summary Two or three different solutions may be used to preserve thoracic and abdominal organs during a single procurement. The aim of this prospective, multi‐center, noncomparative study was to evaluate the safety and efficacy of Celsior® (study solution, solution S) as a flushing and cold storage solution for both thoracic and abdominal organs. Between August 1999 and July 2000, 72 consecutive multiple‐organ procurements were performed using solution S as the sole solution for flushing out and cold‐storing thoracic and abdominal grafts. Two hundred and sixty‐four grafts were implanted into 245 recipients (131 kidneys, 9 kidney–pancreases, 69 livers, 34 hearts and 6 heart–lungs). The mean cold ischemia time was 21 h for kidneys (26%>24 h); 11 h 26 min for pancreases, 9 h 16 min for livers (23%>12 h), and 2 h 58 min for hearts and lungs. No cardiac failure or arrhythmia occurred on graft reperfusion. Fourteen percent of kidney recipients had delayed graft function. The mean serum creatinin level at 3 months was 123 ± 41 μmol/l. All pancreas recipients were insulin‐free at 3 months. Primary graft nonfunction occurred in one liver recipient. Complete hepatic artery thrombosis occurred in six liver recipients during the first month; four of these patients had a risk factor for thrombosis. All but three of the heart recipients were in sinus rhythm on day 1, and 65% were extubated on day 1. Inotropic drugs were necessary during the first 72 h in 25% of heart recipients. Twelve‐month patient and graft survival rates were, respectively, 100% and 96% (kidney), 100% and 89% (pancreas), 88% and 83% (liver), 77.5% (heart) and 67% (heart–lung). These results suggest that Celsior®, a ready‐to‐use solution, is safe and effective for multiple organ procurement and preservation.

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Section: Introductionmentioning

confidence: 95%