2022
DOI: 10.1007/s10334-021-00998-x
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Biopsy-based optimization and calibration of a signal-intensity-ratio-based MRI method (1.5 Tesla) in a dextran-iron loaded mini-pig model, enabling estimation of very high liver iron concentrations

Abstract: Objective Magnetic resonance imaging (MRI)-based techniques for non-invasive assessing liver iron concentration (LIC) in patients with iron overload have a limited upper measuring range around 35 mg/g dry weight, caused by signal loss from accelerated T1-, T2-, T2* shortening with increasing LIC. Expansion of this range is necessary to allow evaluation of patients with very high LIC. Aim To assess measuring range of a gradient-echo R2* method and a T1-weig… Show more

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Cited by 2 publications
(3 citation statements)
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References 86 publications
(168 reference statements)
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“…[ 16 ] However, owing to its invasive nature, high inter-/intra-observer variability, and sampling bias, MR has become a noninvasive method for qualitative and quantitative assessment of liver iron deposition. [ 17 ] Studies have shown that MR techniques for detecting iron deposits in the liver correlate well with liver biopsies. [ 10 , 18 19 20 ]…”
Section: Discussionmentioning
confidence: 99%
“…[ 16 ] However, owing to its invasive nature, high inter-/intra-observer variability, and sampling bias, MR has become a noninvasive method for qualitative and quantitative assessment of liver iron deposition. [ 17 ] Studies have shown that MR techniques for detecting iron deposits in the liver correlate well with liver biopsies. [ 10 , 18 19 20 ]…”
Section: Discussionmentioning
confidence: 99%
“…And it leads to delayed signal loss at high LIC due to the shorter TE, thus allowing the assessment of more severe liver iron overload. In recent years, Jensen et al ( 21 ) found that the upper limit of 1.5 T MRI SIR Measurement range would be extended to 115 mg/g if the relevant parameters TE = 12 ms and TR = 1,200 ms were set in the liver iron overload experiment of quantitative miniature pigs. However, this conclusion was drawn in an animal model and requires further validation in iron-loaded patients.…”
Section: Mri Examinationmentioning
confidence: 99%
“…Then the corresponding signal decay time constants T 2 and T 2 * and the corresponding relaxation rates R 2 (1,000/T 2 ) and R 2 * (1,000/T 2 * ) were obtained ( 1 , 3 , 22 ). Relaxometry is a quantitative assessment of MRI signal loss caused by the shortening of T 2 /T 2 * relaxation times ( 21 , 22 ). Excess iron stored in the body in the form of trivalent iron can shorten T1 and T 2 —as T1 shortens, the corresponding SI increases; The corresponding SI decreases with the shortening of T 2 ( 1 , 3 ).…”
Section: Mri Examinationmentioning
confidence: 99%