Biopsychosocial correlates of psychological distress in Latina mothers

Santos, Hudson P.; Adynski, Harry; Harris, Rebeca; Bhattacharya, Arjun; Rodriguez, Angela C. Incollingo; Cali, Ryan J.; Yabar, Alessandra Torres; Nephew, Benjamin C.; Murgatroyd, Chris

doi:10.1016/j.jad.2020.12.193

Cited by 19 publications

(21 citation statements)

References 104 publications

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“…Although such research recognizes cultural strengths, this focus detracts from multiple dimensions of inequity that may drive the intergenerational cascade of emotional and biological vulnerabilities (Castañeda et al, 2015; Viruell‐Fuentes et al, 2012). Psychosocial responses to the sociocultural context of immigration, such as interpersonal discrimination and acculturative stress, may interact with economic hardship to predict prenatal depressive symptoms (Ponting et al, 2020; Santos et al, 2020) and adverse birth outcomes in Latinas (Earnshaw et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Which roads lead to depression in Latinas? A network analysis of prenatal depressive symptoms, discrimination, acculturative stress, and low birth weight

Harris

Da-qi

Santos

2022

Research in Nursing & Health

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Although immigrant mothers from some Latinx subgroups initially achieve healthy birth outcomes despite lower socioeconomic status, this advantage deteriorates across generations in the United States. Interpersonal discrimination and acculturative stress may interact with economic hardship to predict an intergenerational cascade of emotional and biological vulnerabilities, particularly perinatal depression. Network analyses may elucidate not only how and which psychosocial experiences relate to depressive symptoms, but which symptom-to-symptom relationships emerge. This study aims to understand (1) how economic, acculturative, and discrimination stressors relate to prenatal depression and low birth weight and(2) how Latinas may respond to and cope with stressors by exploring symptom-symptom and symptom-experience relationships. A sample of 151 pregnant Latinas (predominantly foreign-born and Mexican and Central American descent) completed the EPDS and psychosocial questionnaires (discrimination, acculturation, acculturative stress, economic hardship) during pregnancy (24-32 weeks). Birth weights were recorded from postpartum medical records. We created network models using the Extended Bayesian Information Criterion Graphical Least Absolute Shrinkage and Selection Operator to estimate the relationship between variables. Discrimination exposure connected psychosocial stressors to depressive symptoms, particularly worry, crying, sadness, and self-blame. Discrimination also revealed a connection between acculturation and low birth weight.Furthermore, younger age of migration and greater acculturation levels were correlated to greater discrimination stress and low birth weights. Perinatal research in Latinas must account not only for measures of cultural adaptation but recognize how developmental exposures across the life span, including discrimination, may be associated with adverse health trajectories for a mother and her child.

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Section: Introductionmentioning

confidence: 99%

Which roads lead to depression in Latinas? A network analysis of prenatal depressive symptoms, discrimination, acculturative stress, and low birth weight

Harris

Da-qi

Santos

2022

Research in Nursing & Health

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“…This is inconsistent with a previous study conducted in the Democratic Republic of Congo that showed a significant association between mean methylation and peritraumatic distress or mundane stress ( 30 ). Furthermore, a study conducted in the United States showed a significantly strong association between everyday discrimination and NR3C1 gene methylation ( 35 ). Meanwhile, many studies conducted in Africa also found that prenatal war stress was associated with NR3C1 gene methylation ( 30 , 33 ).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies on the effects of stress on maternal DNA methylation mainly focused on the stress of war in war-torn African countries ( 30 , 33 ) or the stress of discrimination among Latina mothers in the United States ( 34 , 35 ). COVID-19 presents a new challenge to humanity as a completely new disease that causes stress unlike the above types of stress.…”

Section: Introductionmentioning

confidence: 99%

The association between peritraumatic distress, perceived stress, depression in pregnancy, and NR3C1 DNA methylation among Chinese pregnant women who experienced COVID-19 lockdown

et al. 2022

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Prenatal stress can affect pregnant women in an epigenetic way during the critical period of conception of their offspring. The study aims to investigate the relationship between peritraumatic distress, prenatal perceived stress, depression, and glucocorticoid receptor (NR3C1) DNA methylation among pregnant women who experienced COVID-19 lockdown in China. Study data were collected from 30 pregnant women in Wuhan and Huanggang, China. The Peritraumatic Distress Inventory was used to measure peritraumatic distress, the Edinburgh Postnatal Depression Scale was used to measure depressive symptoms, and the Perceived Stress Scale was used to measure perceived stress. DNA methylation in the exon 1F promoter region of NR3C1 gene from the venous blood mononuclear cell genome was characterized by bisulfite sequencing. Correlation and linear regression were used for data analysis. The mean level of peritraumatic distress, perceived stress, and depression was 6.30 (SD = 5.09), 6.50 (SD = 5.41), and 6.60 (SD = 4.85), respectively, with 23.33% of pregnant women being depressed. The mean NR3C1 methylation was 0.65 (SD = 0.22). Prenatal depression was positively correlated with the degree of methylation in venous blood from the mother (r = 0.59, p = 0.001), and depression predicted methylation of NR3C1 gene at the CpG 8 site (β = 0.05, p = 0.03). No association was found between peritraumatic distress as well as perceived stress and methylation of NR3C1. NR3C1 gene was susceptible to epigenetic modification of DNA methylation in the context of prenatal stress, and maternal depression was associated with increased NR3C1 methylation among women who experienced COVID-19 lockdown.

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“…Minority groups often face discrimination stress that engages stress physiology and downstream consequences. Recent work in a Latina sample found that discrimination was related to postpartum mood disturbances and that epigenetic modifications of stress‐ and immune‐related genes played a modulating role 72,73 . Racism and resultant social structures have even been proffered as a key social determinant of health conferring increased maternal morbidity and mortality risk 74 …”

Section: The Wombs Frameworkmentioning

confidence: 99%

The WOMBS Framework: A review and new theoretical model for investigating pregnancy‐related weight stigma and its intergenerational implications

Rodriguez

Nagpal

2021

Obesity Reviews

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Summary As the growing weight stigma literature has developed, one critically relevant and vulnerable population has received little consideration—pregnant and postpartum women. Because weight fluctuations are inherent to this life phase, and rates of prepregnancy overweight and obesity are already high, this gap is problematic. More recently, however, there has been a rising interest in pregnancy‐related weight stigma and its consequences. This paper therefore sought to (a) review the emerging research on pregnancy‐related weight stigma phenomenology and (b) integrate this existing evidence to present a novel theoretical framework for studying pregnancy‐related weight stigma. The Weight gain, Obesity, Maternal‐child Biobehavioral pathways, and Stigma (WOMBS) Framework proposes psychophysiological mechanisms linking pregnancy‐related weight stigmatization to increased risk of weight gain and, in turn, downstream childhood obesity risk. This WOMBS Framework highlights pregnant and postpartum women as a theoretically unique at‐risk population for whom this social stigma engages maternal physiology and transfers obesity risk to the child via social and physiological mechanisms. The WOMBS Framework provides a novel and useful tool to guide the emerging pregnancy‐related weight stigma research and, ultimately, support stigma‐reduction efforts in this critical context.

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Biopsychosocial correlates of psychological distress in Latina mothers

Cited by 19 publications

References 104 publications

Which roads lead to depression in Latinas? A network analysis of prenatal depressive symptoms, discrimination, acculturative stress, and low birth weight

Which roads lead to depression in Latinas? A network analysis of prenatal depressive symptoms, discrimination, acculturative stress, and low birth weight

The association between peritraumatic distress, perceived stress, depression in pregnancy, and NR3C1 DNA methylation among Chinese pregnant women who experienced COVID-19 lockdown

The WOMBS Framework: A review and new theoretical model for investigating pregnancy‐related weight stigma and its intergenerational implications

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