Biorelevant Weakly Coordinating Directing Group Assisted C–H Alkenylation with Cyclopropanols via Sequential C–H/C–C Activation

Palladium-Catalyzed Weak Chelation-Assisted Site-Selective C–H Arylation of N-Aryl Pyridones via 2-fold C–H Activation

“…In addition, the presence of an aryl ring at the N atom of the pyridone heterocycle offers a unique opportunity for arene C–H functionalization exploiting weakly coordinating pyridone as an intrinsic directing group (DG). Remarkably, the C3–C6 positions of the pyridone moiety are preferentially functionalized through innate reactivity or chelation-guided C–H bond activation, whereas functionalization of the N -aryl ring utilizing intrinsic pyridone assistance has rarely been explored. , Accessing the arene C–H bond of N -aryl pyridone in the presence of potentially reactive sites on the pyridone ring imposes a formidable synthetic challenge (see Scheme S1a).…”