Bioresorbable elastomeric vascular tissue engineering scaffolds via melt spinning and electrospinning

Chung, Sang-Keun; Ingle, Nilesh P.; Montero, Gerardo A.; Kim, Jeongrae; King, Martin W.

doi:10.1016/j.actbio.2009.12.007

Cited by 145 publications

(102 citation statements)

References 46 publications

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“…Although PCL is highly elastic and strain is more than 700 per cent at breakage [10], the degradation rate of PCL is rather slow for urothelial tissue engineering, taking up to 2 years [10,12]. Various poly-L-lactide-co-1-caprolactone (PLCL) compositions have been studied in tissue engineering applications [13][14][15][16][17][18], but the main focus has been on producing electrospun nanofibrous membranes. In our recent study [19], we showed that compression-moulded smooth PLCL membranes supported the proliferation and differentiation of hUCs better than human amniotic membrane.…”

Section: Introductionmentioning

confidence: 99%

Characterizing and optimizing poly- l -lactide-co-ε-caprolactone membranes for urothelial tissue engineering

Sartoneva

Haaparanta

Lahdes-Vasama

et al. 2012

J. R. Soc. Interface.

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Different synthetic biomaterials such as polylactide (PLA), polycaprolactone and poly-Llactide-co-1-caprolactone (PLCL) have been studied for urothelial tissue engineering, with favourable results. The aim of this research was to further optimize the growth surface for human urothelial cells (hUCs) by comparing different PLCL-based membranes: smooth (s) and textured (t) PLCL and knitted PLA mesh with compression-moulded PLCL (cPLCL). The effects of topographical texturing on urothelial cell response and mechanical properties under hydrolysis were studied. The main finding was that both sPLCL and tPLCL supported hUC growth significantly better than cPLCL. Interestingly, tPLCL gave no significant advantage to hUC attachment or proliferation compared with sPLCL. However, during the 14 day assessment period, the majority of cells were viable and maintained phenotype on all the membranes studied. The material characterization exhibited potential mechanical characteristics of sPLCL and tPLCL for urothelial applications. Furthermore, the highest elongation of tPLCL supports the use of this kind of texturing. In conclusion, in light of our cell culture results and mechanical characterization, both sPLCL and tPLCL should be further studied for urothelial tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Characterizing and optimizing poly- l -lactide-co-ε-caprolactone membranes for urothelial tissue engineering

Sartoneva

Haaparanta

Lahdes-Vasama

et al. 2012

J. R. Soc. Interface.

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“…Porosity and thereby cell penetration could be enhanced in scaffolds by using the strategy of creating a 3D nano-/micro-architecture, where nanofibers are combined with microfibers [18][19][20][21][22]. Nano-/micro-fibrous scaffolds have an innovative structure, inspired by an ECM that combines a nano-network, aimed to promote cell adhesion, with a micro-fiber mesh to generate the 3-D structure [23,24]. Although micro-fibrous scaffolds are not on the same size scale as ECM components, they could potentially be advantageous because they are composed of larger pores as compared to nano-fibrous scaffolds [25].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of bioactive polycaprolactone/hydroxyapatite scaffolds with final bilayer nano-/micro-fibrous structures for tissue engineering application

Rajzer

2014

J Mater Sci

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In this study, two techniques, namely electrospinning and needle-punching processes, were used to fabricate bioactive polycaprolactone/hydroxyapatite scaffolds with a final bilayer nano-/micro-fibrous porous structure. A hybrid scaffold was fabricated to combine the beneficial properties of nanofibers and microfibers and to create a three-dimensional porous structure (which is usually very difficult to produce using electrospinning technology only). The first part of this work focused on determining the conditions necessary to fabricate nano-and micro-fibrous components of scaffold layers. A characterization of scaffold components, with respect to their morphology, fiber diameter, pore size, wettability, chemical composition and mechanical properties, was performed. Then, the same process parameters were applied to produce a hybrid bilayer scaffold by electrospinning the nanofibers directly onto the micro-fibrous nonwovens obtained in a traditional mechanical needle-punching process. In the second part, the bioactive character of a hybrid nano-/ micro-fibrous scaffold in simulated body fluid (SBF) was assessed. Spherical calcium phosphate was precipitated onto the nano-/micro-fibrous scaffold surface proving its bioactivity.

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“…Moreover, it has low tensile strength (~23 MPa), but very high elongation at breakage (4700 %) making it a good elastic biomaterial [81] [182]. PCL is used in the production of implants composed of adhered nano/microspheres [183], electrospun fibers [184,185], or porous networks [186] used for regeneration of bone [187,188], ligament [189,190], cartilage [191], nerve [192], and vascular tissues [193]. In addition, PCL is often blended or copolymerized with other polymers like polyesters and polyethers to expedite overall polymer erosion [194].…”

Section: Polyestersmentioning

confidence: 99%

Biodegradable polymers for dental tissue engineering and regeneration

Conte¹,

Riccitiello²,

Luise³

et al. 2017

Biodegradable Polymers: Recent Developments and New Perspectives

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Bioresorbable elastomeric vascular tissue engineering scaffolds via melt spinning and electrospinning

Cited by 145 publications

References 46 publications

Characterizing and optimizing poly- l -lactide-co-ε-caprolactone membranes for urothelial tissue engineering

Characterizing and optimizing poly- l -lactide-co-ε-caprolactone membranes for urothelial tissue engineering

Fabrication of bioactive polycaprolactone/hydroxyapatite scaffolds with final bilayer nano-/micro-fibrous structures for tissue engineering application

Biodegradable polymers for dental tissue engineering and regeneration

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