Bioresorbable filomicelles for targeted delivery of betulin derivative – In vitro study

Jelonek, Katarzyna; Kasperczyk, Janusz; Li, Suming; Nguyen, Thi Hong Nhung; Orchel, Arkadiusz; Chodurek, Ewa; Paduszyński, Piotr; Jaworska-Kik, Marzena; Chrobak, Elwira; Bębenek, Ewa; Boryczka, Stanisław; Jarosz-Biej, Magdalena; Smolarczyk, Ryszard; Foryś, Aleksander

doi:10.1016/j.ijpharm.2018.12.033

Cited by 19 publications

(18 citation statements)

References 32 publications

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“…The vitamin receptors, especially a folate and biotin receptors are overexpressed on the cancer cells and may function as drug targeting biomarkers. 9,35‐37 In the breast cancer the overexpression of biotin receptor is even higher than the folate receptor 35,38 . Therefore, PLA–PEG‐BIO micelles can be considered as a tool for tumor‐targeting drug delivery in breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic effect of targeted biodegradable epothilone B and rapamycin co‐loaded nanocarriers on breast cancer cells

Zajdel

Wilczok

Jelonek

et al. 2021

J Biomedical Materials Res

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The new therapeutic solutions for breast cancer treatment are needed, for example, combined therapy consisted of several drugs that characterize different mechanisms of action and modern drug delivery systems. Therefore, we used combination of epothilone B (EpoB) and rapamycin (Rap) to analyze the cytotoxic effect against breast cancer cells (MCF‐7; MDA‐MB‐231). Also, the effect of drugs co‐delivered in bioresorbable micelles functionalized with biotin (PLA–PEG‐BIO; poly(lactide)‐co‐poly(ethylene glycol)‐biotin) was studied. The comparison of effects of the mixture of free drugs and the micelles co‐loaded with EpoB and Rap revealed a significant decrease in the cell metabolic activity and survival. Moreover, the dual drug‐loaded PLA–PEG‐BIO micelles enhanced the cytotoxicity of EpoB and Rap against the tested cells as compared with the free drugs. The blank PLA–PEG‐BIO micelles did not affect the tested cells. We expect that mixture of EpoB and Rap may be promising in breast cancer treatment and PLA–PEG‐BIO micelles as carrier of these two drugs can be applicable for successful targeted delivery.

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Section: Discussionmentioning

confidence: 99%

Cytotoxic effect of targeted biodegradable epothilone B and rapamycin co‐loaded nanocarriers on breast cancer cells

Zajdel

Wilczok

Jelonek

et al. 2021

J Biomedical Materials Res

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“…The study is also conducted to develop FA targeted filomicelles that can enter cells by receptor-mediated endocytosis, which can potentially maximize therapeutic efficacy while minimizing side effects. We have reported on the development of FA-targeted filomicelles obtained from the mixture of the newly synthesized and characterized PLA-Jeffamine-FA polymer and PLA-PEG [23]. Jeffamine (Fig.…”

Section: Introductionmentioning

confidence: 99%

“…in nanoparticle decoration [26], thermo-responsive hydrogels for drug delivery [27], thermo-associative nanoparticles for drug delivery [28], preparation of micelles [24,25]. The micelles obtained from PLA-PEG/PLA-Jeffamine-FA characterized the prolonged release of anticancer agent, successful in vitro internalization by FR-positive HeLa cell line and cytotoxicity of drug-loaded loaded micelles against anticancer cells [23]. It is also important to note that the Jeffamine® ED used in the synthesis of PLA-Jeffamine-FA has confirmed biocompatibility [29].…”

Section: Introductionmentioning

confidence: 99%

Correlation between the composition of PLA-based folate targeted micelles and release of phosphonate derivative of betulin

Jelonek

Kaczmarczyk

Orchel

et al. 2021

Journal of Drug Delivery Science and Technology

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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“…PLA is among the most common hydrophobic blocks that form the inner core due to its bioresorption and biocompatibility [24]. PLA-PEG micelles for single or multidrug delivery have been developed [25,26,27,28].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Effect of Paclitaxel and Lapatinib Co-Delivered in Polylactide-co-Poly(ethylene glycol) Micelles on HER-2-Negative Breast Cancer Cells

et al. 2019

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To find better strategies to enhance the cytotoxic effect of paclitaxel (PTX) and lapatinib (LAP) against breast cancer cells, we analyzed the efficacy of a novel delivery system containing polylactide-co-poly(ethylene glycol) (PLA-PEG) filomicelles of over 100 nm in length and spherical micelles of approximately 20 nm in diameter. The 1H NMR measurements confirmed the incorporation of PTX and LAP into micelles. Analysis of the drug release mechanism revealed the diffusion-controlled release of LAP and anomalous transport of PTX. Drug content analysis in lyophilized micelles and micellar solution showed their good storage stability for at least 6 weeks. Blank micelles, LAP-loaded micelles and free LAP did not affect MCF-7 breast cancer cell proliferation, suggesting that the cytotoxicity of PTX-, PTX/LAP-loaded micelles, and the binary mixture of free PTX and LAP was solely caused by PTX. PTX/LAP-loaded micelles showed greater toxicity compared to the binary mixture of PTX and LAP after 48 h and 72 h. Only free PTX alone induced P-gp activity. This study showed the feasibility of using a LAP and PTX combination to overcome MDR in MCF-7 cells, particularly when co-loaded into micelles. We suggest that PTX/LAP micelles can be applicable not only for the therapy of HER-2-positive, but also HER-2-negative breast cancers.

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Bioresorbable filomicelles for targeted delivery of betulin derivative – In vitro study

Cited by 19 publications

References 32 publications

Cytotoxic effect of targeted biodegradable epothilone B and rapamycin co‐loaded nanocarriers on breast cancer cells

Cytotoxic effect of targeted biodegradable epothilone B and rapamycin co‐loaded nanocarriers on breast cancer cells

Correlation between the composition of PLA-based folate targeted micelles and release of phosphonate derivative of betulin

Cytotoxic Effect of Paclitaxel and Lapatinib Co-Delivered in Polylactide-co-Poly(ethylene glycol) Micelles on HER-2-Negative Breast Cancer Cells

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