Bioresorbable Materials for Orthopedic Applications (Lactide and Glycolide Based)

Prabhu, Balaji; Karau, Andreas; Wood, Andrew; Dadsetan, Mahrokh; Liedtke, H.; DeWitt, Todd

doi:10.1007/978-3-319-89542-0_13

Cited by 12 publications

(13 citation statements)

References 147 publications

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“…In all histological analyses, particularly at a high magnification field, new bone growth was observed in the region closely contacted to the suture anchors. The findings of the polymer SA are compatible with those of previous studies [ 26 , 27 ]. Our results revealed high biocompatibility of the iron SA; this finding is compatible with those of the MTT assay and SEM analysis ( Figure 2 A,B).…”

Section: Resultssupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

“…The synthetic polymer SA used in this study consisted of 20% calcium sulfate and 15% β-TCP [ 27 , 28 , 29 ] and was expected to result in favorable bone growth. Our histological and micro-CT examination demonstrated favorable bone growth; these findings are compatible with those of previous studies [ 27 , 28 , 29 ]. As shown in Figure 2 B, the results of SEM analysis demonstrated cell attachment on the implant with lamellipodial and filopodial extrusions; this result is compatible with the histopathological finding ( Figure 7 ) that demonstrated satisfactory cell contact with the implant.…”

Section: Discussionmentioning

confidence: 99%

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Biocompatibility and Biological Performance Evaluation of Additive-Manufactured Bioabsorbable Iron-Based Porous Suture Anchor in a Rabbit Model

Tai

Liaw

et al. 2021

IJMS

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This study evaluated the biocompatibility and biological performance of novel additive-manufactured bioabsorbable iron-based porous suture anchors (iron_SAs). Two types of bioabsorbable iron_SAs, with double- and triple-helical structures (iron_SA_2_helix and iron_SA_3_helix, respectively), were compared with the synthetic polymer-based bioabsorbable suture anchor (polymer_SAs). An in vitro mechanical test, MTT assay, and scanning electron microscope (SEM) analysis were performed. An in vivo animal study was also performed. The three types of suture anchors were randomly implanted in the outer cortex of the lateral femoral condyle. The ultimate in vitro pullout strength of the iron_SA_3_helix group was significantly higher than the iron_SA_2_helix and polymer_SA groups. The MTT assay findings demonstrated no significant cytotoxicity, and the SEM analysis showed cells attachment on implant surface. The ultimate failure load of the iron_SA_3_helix group was significantly higher than that of the polymer_SA group. The micro-CT analysis indicated the iron_SA_3_helix group showed a higher bone volume fraction (BV/TV) after surgery. Moreover, both iron SAs underwent degradation with time. Iron_SAs with triple-helical threads and a porous structure demonstrated better mechanical strength and high biocompatibility after short-term implantation. The combined advantages of the mechanical superiority of the iron metal and the possibility of absorption after implantation make the iron_SA a suitable candidate for further development.

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Section: Resultssupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Biocompatibility and Biological Performance Evaluation of Additive-Manufactured Bioabsorbable Iron-Based Porous Suture Anchor in a Rabbit Model

Tai

Liaw

et al. 2021

IJMS

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“…The Tg of PLGA copolymers is usually in the range of 40–60°C. 108 PLGA is a synthetic polymer that has been regularly used in orthopedic implants, surgical technique development, drug delivery systems, and tissue engineering scaffolds due to its exceptional mechanical and physical properties, biodegradability, and biocompatibility. 106 , 109–111 PLGA is one of the best characterized biodegradable copolymers thereby accounting for its long clinical experience and use in developing sustained drug delivery systems.…”

Section: Biomaterials For 3d Printing Of Bone Substitutesmentioning

confidence: 99%

3D Printing of Micro- and Nanoscale Bone Substitutes: A Review on Technical and Translational Perspectives

Cheng

et al. 2021

IJN

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Recent developments in three-dimensional (3D) printing technology offer immense potential in fabricating scaffolds and implants for various biomedical applications, especially for bone repair and regeneration. As the availability of autologous bone sources and commercial products is limited and surgical methods do not help in complete regeneration, it is necessary to develop alternative approaches for repairing large segmental bone defects. The 3D printing technology can effectively integrate different types of living cells within a 3D construct made up of conventional micro- or nanoscale biomaterials to create an artificial bone graft capable of regenerating the damaged tissues. This article reviews the developments and applications of 3D printing in bone tissue engineering and highlights the numerous conventional biomaterials and nanomaterials that have been used in the production of 3D-printed scaffolds. A comprehensive overview of the 3D printing methods such as stereolithography (SLA), selective laser sintering (SLS), fused deposition modeling (FDM), and ink-jet 3D printing, and their technical and clinical applications in bone repair and regeneration has been provided. The review is expected to be useful for readers to gain an insight into the state-of-the-art of 3D printing of bone substitutes and their translational perspectives.

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“…As they are fully absorbed by the body and present excellent biocompatibility properties, they have generated immense interest for the manufacturing of scaffolds for tissue engineering and regenerative applications [7]. Indeed, using a bioabsorbable polymer improves patient post-healing, as it avoids needing a second intervention to remove the implant [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Effects of Two Melt Extrusion Based Additive Manufacturing Technologies and Common Sterilization Methods on the Properties of a Medical Grade PLGA Copolymer

et al. 2021

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Although bioabsorbable polymers have garnered increasing attention because of their potential in tissue engineering applications, to our knowledge there are only a few bioabsorbable 3D printed medical devices on the market thus far. In this study, we assessed the processability of medical grade Poly(lactic-co-glycolic) Acid (PLGA)85:15 via two additive manufacturing technologies: Fused Filament Fabrication (FFF) and Direct Pellet Printing (DPP) to highlight the least destructive technology towards PLGA. To quantify PLGA degradation, its molecular weight (gel permeation chromatography (GPC)) as well as its thermal properties (differential scanning calorimetry (DSC)) were evaluated at each processing step, including sterilization with conventional methods (ethylene oxide, gamma, and beta irradiation). Results show that 3D printing of PLGA on a DPP printer significantly decreased the number-average molecular weight (Mn) to the greatest extent (26% Mn loss, p < 0.0001) as it applies a longer residence time and higher shear stress compared to classic FFF (19% Mn loss, p < 0.0001). Among all sterilization methods tested, ethylene oxide seems to be the most appropriate, as it leads to no significant changes in PLGA properties. After sterilization, all samples were considered to be non-toxic, as cell viability was above 70% compared to the control, indicating that this manufacturing route could be used for the development of bioabsorbable medical devices. Based on our observations, we recommend using FFF printing and ethylene oxide sterilization to produce PLGA medical devices.

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Bioresorbable Materials for Orthopedic Applications (Lactide and Glycolide Based)

Cited by 12 publications

References 147 publications

Biocompatibility and Biological Performance Evaluation of Additive-Manufactured Bioabsorbable Iron-Based Porous Suture Anchor in a Rabbit Model

Biocompatibility and Biological Performance Evaluation of Additive-Manufactured Bioabsorbable Iron-Based Porous Suture Anchor in a Rabbit Model

3D Printing of Micro- and Nanoscale Bone Substitutes: A Review on Technical and Translational Perspectives

Effects of Two Melt Extrusion Based Additive Manufacturing Technologies and Common Sterilization Methods on the Properties of a Medical Grade PLGA Copolymer

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