Bioresorbable Polymer Coated Drug Eluting Stent: A Model Study

Rossi, Filippo; Casalini, Tommaso; Raffa, E.; Masi, Maurizio; Perale, Giuseppe

doi:10.1021/mp200573f

Cited by 37 publications

(22 citation statements)

References 80 publications

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“…Recent investigations have been working on the development of efficient NO-related materials for clinical demands [5][6][7] . In relation to cardiovascular disease (CVD) therapies, although implants like vascular stents have demonstrated its benefit effects, thrombus formation and intimal hyperplasia are still concerns [6][7][8] . One of the main topics of stent design is 'rapid endothelialization', mainly ascribed to the essentially inherent properties of generating NO via eNOS in the endothelial cell (EC) layer 9,10 .…”

Section: Introductionmentioning

confidence: 99%

Copper-Incorporated Collagen/Catechol Film for in Situ Generation of Nitric Oxide

Luo

Liu

Yao

et al. 2015

ACS Biomater. Sci. Eng.

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Local and continuous release of nitric oxide (NO) has been suggested to be a potential and desirable demand for blood contacting implants. However, the life time of NO release from polymer films is limited by the reservoir of loaded NO donor. In situ generation of NO via catalytic decomposing the endogenous S-nitrosothiols (RSNOs) at the blood/material interface is a novel and challenging approach. Herein, a copper-incorporated film was constructed with the copolymerization of catechols (catechol or epigallocatechin gallate (EGCG)) and collagen. FT-IR results suggested the successful deposition of catechol/collagen copolymer film. The XPS results demonstrated the existence of copper on the surfaces. AFM results demonstrated that copper particles were formed in the thin polymeric film. Copper-incorporated samples presented a capability of generating physiological levels of NO. Difference of the generated amount of NO was associated with the Cu (I) concentration during the testing period, demonstrated by micro-BCA assay. NO-generating films not only significant properties on inhibiting platelet activation and adhesion, but also dramatically decreased smooth muscle cell adhesion. Such copper-incorporated film might suggest potential in the design of vascular devices.

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Section: Introductionmentioning

confidence: 99%

Copper-Incorporated Collagen/Catechol Film for in Situ Generation of Nitric Oxide

Luo

Liu

Yao

et al. 2015

ACS Biomater. Sci. Eng.

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“…[20][21][22] Biodegradable polymers such as poly(lactic acid) (PLA) and poly(lactic-co-glycolic acid) have also been explored as completely degradable platforms and as stent coatings. 10,11,[23][24][25][26][27] The immobilization of heparin as an anti-coagulant on the surfaces of stent coatings has been employed with the aim of imparting non-thrombogenic properties, and has met with variable success. [28][29][30][31] The conjugation of antibodies aimed at capturing endothelial progenitor cells to promote re-endothelialization are also being explored.…”

mentioning

confidence: 99%

Covalent Polyisobutylene–Paclitaxel Conjugates for Controlled Release from Potential Vascular Stent Coatings

Trant

McEachran

Sran

et al. 2015

ACS Appl. Mater. Interfaces

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The development of covalent polyisobutylene (PIB)-paclitaxel (PTX) conjugates as a potential approach to controlling drug release from vascular stent coatings is described. PIB-PTX materials containing ∼24 and ∼48 wt % PTX, conjugated via ester linkages, were prepared. The PTX release profiles were compared with those of physical mixtures of PTX with carboxylic acid-functionalized PIB and with the triblock copolymer polystyrene-b-PIB-b-polystyrene (SIBS). Covalent conjugation led to significantly slower drug release. Atomic force microscopy imaging of coatings of the materials suggested that the physical mixtures exhibited multiple domains corresponding to phase separation, whereas the materials in which PTX was covalently conjugated appeared homogeneous. Coatings of the conjugated materials on stainless steel surfaces suffered less surface erosion than the physically mixed materials, remained intact, and adhered well to the surface throughout the thirty-five day study. Tensile testing and rheological studies suggested that the incorporation of PTX into the polymer introduces similar physical changes to the PIB as the incorporation of a glassy polystyrene block does in SIBS. Cytotoxicity assays showed that the coatings did not release toxic levels of PTX or other species into a cell culture medium over a 24 h period, yet the levels of PTX in the materials were sufficient to prevent C2C12 cells from adhering to and proliferating on them. Overall, these results indicate that covalent PIB-PTX conjugates have promise as coatings for vascular stents.

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“…The sirolimus and ALA eluted more quickly from SAS than SES and AES because the amount of coating polymer of SAS was less than other stents for same coating thickness. Other study reported that 'with the increase of drug-topolymer ratio, the release rate increases [24,25]. '…”

Section: Evaluation Of Aes Ses and Sasmentioning

confidence: 99%

Effect of stents coated with a combination of sirolimus and alpha-lipoic acid in a porcine coronary restenosis model

Lim

Park

Jeong

et al. 2016

J Mater Sci: Mater Med

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The aim of this study was to evaluate antiproliferative sirolimus- and antioxidative alpha-lipoic acid (ALA)-eluting stents using biodegradable polymer [poly-L-lactic acid (PLA)] in a porcine coronary overstretch restenosis model. Forty coronary arteries of 20 pigs were randomized into four groups in which the coronary arteries had a bare metal stent (BMS, n = 10), ALA-eluting stent with PLA (AES, n = 10), sirolimus-eluting stent with PLA (SES, n = 10), or sirolimus- and ALA-eluting stent with PLA (SAS, n = 10). A histopathological analysis was performed 28 days after the stenting. The ALA and sirolimus released slowly over 30 days. There were no significant differences between groups in the injury or inflammation score; however, there were significant differences in the percent area of stenosis (56.2 ± 11.78% in BMS vs. 51.5 ± 12.20% in AES vs. 34.7 ± 7.23% in SES vs. 28.7 ± 7.30% in SAS, P < 0.0001) and fibrin score [1.0 (range 1.0-1.0) in BMS vs. 1.0 (range 1.0-1.0) in AES vs. 2.0 (range 2.0-2.0) in SES vs. 2.0 (range 2.0-2.0) in SAS, P < 0.0001] between the four groups. The percent area of stenosis based on micro-computed tomography corresponded with the restenosis rates based on histopathological stenosis in different proportions in the four groups (54.8 ± 7.88% in BMS vs. 50.4 ± 14.87% in AES vs. 34.5 ± 7.22% in SES vs. 28.9 ± 7.22% in SAS, P < 0.05). SAS showed a better neointimal inhibitory effect than BMS, AES, and SES at 1 month after stenting in a porcine coronary restenosis model. Therefore, SAS with PLA can be a useful drug combination for coronary stent coating to suppress neointimal hyperplasia.

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Bioresorbable Polymer Coated Drug Eluting Stent: A Model Study

Cited by 37 publications

References 80 publications

Copper-Incorporated Collagen/Catechol Film for in Situ Generation of Nitric Oxide

Copper-Incorporated Collagen/Catechol Film for in Situ Generation of Nitric Oxide

Covalent Polyisobutylene–Paclitaxel Conjugates for Controlled Release from Potential Vascular Stent Coatings

Effect of stents coated with a combination of sirolimus and alpha-lipoic acid in a porcine coronary restenosis model

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