Bioresorbable thin-film silicon diodes for the optoelectronic excitation and inhibition of neural activities

Huang, Yilun; Cui, Yuting; Deng, Hanjie; Wang, Jingjing; Hong, Rongqi; Hu, Shuhan; Hou, Hanqing; Dong, Yuanrui; Wang, Huachun; Chen, Junyu; Li, Lizhu; Xie, Yang; Sun, Peng; Fu, Xin; Yin, Lan; Xiong, Wei; Shi, Song-Hai; Luo, Minmin; Wang, Shirong; Li, Xiaojian; Sheng, Xing

doi:10.1038/s41551-022-00931-0

Cited by 48 publications

(48 citation statements)

References 87 publications

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“…Moreover, both the host material (PCL) and thin-film Si are degradable in a biological environment, implicating their use in tissue regeneration ( 36 , 37 ). Since compositional materials of the scaffold would take a long time to naturally disappear in the physiological condition at 37°C [for example, 1 to 2 years for PCL ( 38 ) and 3 to 6 months for Si ( 39 )], we evaluate the accelerated dissolution process of the scaffold immersed in the phosphate-buffered saline (PBS) solution at 60°C ( Fig. 2D ).…”

Section: Resultsmentioning

confidence: 99%

“…To further understand the results, we establish a circuit model to simulate the Si/cell interaction (fig. S10) ( 39 , 51 , 52 ). In the simulation, the Si/cell interface is modeled by a faradaic impedance ( Z faradaic ).…”

Section: Resultsmentioning

confidence: 99%

“…Advanced Si device design could be envisioned to further improve the optoelectronic response and effectiveness for biological modulations. For instance, Si pn diode structures incorporating coplanar stimulation and return electrodes can be adopted for in vivo optoelectronic stimulations ( 29 , 39 , 66 ). In addition, the current scaffold only has layers of microstructured Si for in vivo demonstration.…”

Section: Discussionmentioning

confidence: 99%

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A 3D biomimetic optoelectronic scaffold repairs cranial defects

et al. 2023

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Bone fractures and defects pose serious health-related issues on patients. For clinical therapeutics, synthetic scaffolds have been actively explored to promote critical-sized bone regeneration, and electrical stimulations are recognized as an effective auxiliary to facilitate the process. Here, we develop a three-dimensional (3D) biomimetic scaffold integrated with thin-film silicon (Si)–based microstructures. This Si-based hybrid scaffold not only provides a 3D hierarchical structure for guiding cell growth but also regulates cell behaviors via photo-induced electrical signals. Remotely controlled by infrared illumination, these Si structures electrically modulate membrane potentials and intracellular calcium dynamics of stem cells and potentiate cell proliferation and differentiation. In a rodent model, the Si-integrated scaffold demonstrates improved osteogenesis under optical stimulations. Such a wirelessly powered optoelectronic scaffold eliminates tethered electrical implants and fully degrades in a biological environment. The Si-based 3D scaffold combines topographical and optoelectronic stimuli for effective biological modulations, offering broad potential for biomedicine.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A 3D biomimetic optoelectronic scaffold repairs cranial defects

et al. 2023

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“…conditions and structural architecture. Moreover, both dynamic and passive behaviors, mirroring biological behavior with potential in biomedical applications, [25] are hardly integrated into these generators. To take the nature-inspired soft devices to the next level, hybrid dynamic ionic electroresponse and passive unremitting power output should be devised holistically, capitalizing on the materials principle of upcycling biowaste for the circular economy.…”

Section: (2 Of 10)mentioning

confidence: 99%

Differentiated Ionic Electroresponse of Asymmetric Bio‐Hydrogels with Unremitting Power Output

Pan

Jin

Zhou

et al. 2023

Advanced Energy Materials

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Cytomembranes with efficient ionic selectivity and energy circulation, essential for biological activities in multicellular organisms, are a source of inspiration for man‐made biomedical devices. However, current man‐made soft systems mainly imitate simple and passive cytomembranes behaviors, restrained by the grand challenge that lies at the meeting point of synchronous engineering of both (dynamic) ionic selectivity and (passive) transcellular‐like potential in one structure. Here a dynamically differentiated ionic electroresponse and passive incessant power output of an asymmetric bio‐hydrogel constructed using a simple self‐propagative flow approach are reported. The unprecedented freely formed p and n analogue hydrogels yield a transcellular‐like potential (110–200 mV) in response to diverse stimuli—where the cathode or anode is capable of perceivable electroresponse to water and/or salt media, respectively. A single hydrogel can generate an output power density of 135–190 mW m−2 superior to most bio‐inspired soft and/or green power sources. The scalable manufacturing and proof‐of‐concept demonstration elucidate the feasibility of mobilizing passive and dynamic behaviors in one structure. This work has the potential for realizing high‐performance soft power sources in parallel to electrostimulation for neural excitation/inhibition, extending into the previously inaccessible region of biomedical applications.

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“…Brain interface technology is a bio-electronic bridging platform for monitoring brain activity [ 1 , 2 , 3 , 4 , 5 ] or modulating brain function [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ] by connecting electronic devices to the neurological system. Owing to its technological-convergence-related benefits [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ], brain interface platforms could be applied to various advanced biomechatronic-associated areas that include: (i) biomedical applications, such as the diagnosis and therapy of neuropathy, daily biomonitoring, healthcare, recovery of brain function from trauma or injury, rehabilitation, and prosthetics for quadriplegia and motor or sensory dysfunction; (ii) human–machine connection for the remote control of objects and avatar robotics; (iii) human enhancement technology, such as memory reinforcement and cognitive function extension; and (iv) tangible user-experience media, such as immersive virtual or augmented reality, metaverse contents, and realistic interactive gaming.…”

Section: Introductionmentioning

confidence: 99%

Stretchable Surface Electrode Arrays Using an Alginate/PEDOT:PSS-Based Conductive Hydrogel for Conformal Brain Interfacing

et al. 2022

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An electrocorticogram (ECoG) is the electrical activity obtainable from the cerebral cortex and an informative source with considerable potential for future advanced applications in various brain−interfacing technologies. Considerable effort has been devoted to developing biocompatible, conformal, soft, and conductive interfacial materials for bridging devices and brain tissue; however, the implementation of brain−adaptive materials with optimized electrical and mechanical characteristics remains challenging. Herein, we present surface electrode arrays using the soft tough ionic conductive hydrogel (STICH). The newly proposed STICH features brain−adaptive softness with Young’s modulus of ~9.46 kPa, which is sufficient to form a conformal interface with the cortex. Additionally, the STICH has high toughness of ~ 36.85 kJ/mm3, highlighting its robustness for maintaining the solid structure during interfacing with wet brain tissue. The stretchable metal electrodes with a wavy pattern printed on the elastomer were coated with the STICH as an interfacial layer, resulting in an improvement of the impedance from 60 kΩ to 10 kΩ at 1 kHz after coating. Acute in vivo experiments for ECoG monitoring were performed in anesthetized rodents, thereby successfully realizing conformal interfacing to the animal’s cortex and the sensitive recording of electrical activity using the STICH−coated electrodes, which exhibited a higher visual−evoked potential (VEP) amplitude than that of the control device.

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Bioresorbable thin-film silicon diodes for the optoelectronic excitation and inhibition of neural activities

Cited by 48 publications

References 87 publications

A 3D biomimetic optoelectronic scaffold repairs cranial defects

A 3D biomimetic optoelectronic scaffold repairs cranial defects

Differentiated Ionic Electroresponse of Asymmetric Bio‐Hydrogels with Unremitting Power Output

Stretchable Surface Electrode Arrays Using an Alginate/PEDOT:PSS-Based Conductive Hydrogel for Conformal Brain Interfacing

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