Bioresponsive drug delivery systems

Alavi, Seyed Ebrahim; Alharthi, Sitah; Alavi, Seyed Zeinab; Raza, Aun; Ebrahimi Shahmabadi, Hasan

doi:10.1016/j.drudis.2023.103849

Cited by 15 publications

(7 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polymers have become the preferred material for constructing these systems, owing to their versatile properties, which enable meticulous control over material characteristics. Moreover, polymers can undergo substantial changes in their properties when exposed to specific stimuli, facilitating controlled and targeted drug release. , …”

Section: Drug Delivery Systems For Wound Healing and Skin Regenerationmentioning

confidence: 99%

“…Moreover, polymers can undergo substantial changes in their properties when exposed to specific stimuli, facilitating controlled and targeted drug release. 136,137 Stimuli-responsive DDSs offer several advantages over passive release systems. They provide precise control over spatial, temporal, and dosage aspects of drug release, ensuring that drugs are released only when needed.…”

Section: Microparticlesmentioning

confidence: 99%

See 1 more Smart Citation

Revolutionizing Wound Healing: Exploring Scarless Solutions through Drug Delivery Innovations

Alavi,

Nisa

et al. 2024

Mol. Pharmaceutics

Self Cite

View full text Add to dashboard Cite

Human skin is the largest organ and outermost surface of the human body, and due to the continuous exposure to various challenges, it is prone to develop injuries, customarily known as wounds. Although various tissue engineering strategies and bioactive wound matrices have been employed to speed up wound healing, scarring remains a significant challenge. The wound environment is harsh due to the presence of degradative enzymes and elevated pH levels, and the physiological processes involved in tissue regeneration operate on distinct time scales. Therefore, there is a need for effective drug delivery systems (DDSs) to address these issues. The objective of this review is to provide a comprehensive exposition of the mechanisms underlying the skin healing process, the factors and materials used in engineering DDSs, and the different DDSs used in wound care. Furthermore, this investigation will delve into the examination of emergent technologies and potential avenues for enhancing the efficacy of wound care devices.

show abstract

Section: Drug Delivery Systems For Wound Healing and Skin Regenerationmentioning

confidence: 99%

Section: Microparticlesmentioning

confidence: 99%

Revolutionizing Wound Healing: Exploring Scarless Solutions through Drug Delivery Innovations

Alavi,

Nisa

et al. 2024

Mol. Pharmaceutics

Self Cite

View full text Add to dashboard Cite

show abstract

“…Drug delivery systems overcome some issues associated with drugs, among which are issues related to stability, the specific targeting of cells and tissues, stabilization of drugs and control of release rates, solubility, bioavailability, and therapeutic outcomes [5].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…Drug delivery systems (DDSs) are designed to provide an efficient transport of the therapeutic agent to the cellular target, through improved aqueous solubility, chemical stability and higher pharmacological activity [4,5]. The selection of drug carriers, additives and processing is also important for the safe and effective transport of the drug molecules [6].…”

Section: Introductionmentioning

confidence: 99%

The Emerging Role of Silk Fibroin for the Development of Novel Drug Delivery Systems

Pollini,

Paladini

2024

Biomimetics

View full text Add to dashboard Cite

In order to reduce the toxicological impact on healthy cells and to improve the therapeutic response, many drug delivery systems have been fabricated and analysed, involving the use of different natural and synthetic materials at macro-, micro- and nanoscales. Among the natural materials which have demonstrated a huge potential for the development of effective drug delivery systems, silk fibroin has emerged for its excellent biological properties and for the possibility to be processed in a wide range of forms, which can be compliant with multiple active molecules and pharmaceutical ingredients for the treatment of various diseases. This review aims at presenting silk fibroin as an interesting biopolymer for applications in drug delivery systems, exploring the results obtained in recent works in terms of technological progress and effectiveness in vitro and in vivo.

show abstract

“…The presence or upregulation of the target protease in a pathological condition results in the disease dependent release of the active substance (e.g., brentuximab vedotin) . This means that a focused or localized intervention in the progression of the disease can be triggered and unwanted off-target effects can be avoided …”

Section: Introductionmentioning

confidence: 99%

An Introductory Guide to Protease Sensitive Linker Design Using Matrix Metalloproteinase 13 as an Example

Hamm,

Meinel,

Driessen

2024

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Proteases play a crucial role, not only in physiological, but also in pathological processes, such as cancer, inflammation, arthritis, Alzheimer's, and infections, to name but a few. Their ability to cleave peptides can be harnessed for a broad range of biotechnological purposes. To do this efficiently, it is essential to find an amino acid sequence that meets the necessary requirements, including interdependent factors like specificity, selectivity, cleavage kinetics, or synthetic accessibility. Cleavage sequences from natural substrates of the protease may not be optimal in terms of specificity and selectivity, which is why these frequently require arduous and sometimes unsuccessful optimization such as by iterative exchange of single amino acids. Hence, here we describe the systematic design of protease sensitive linkers (PSLs)�peptide sequences specifically cleaved by a target protease�guided by the mass spectrometry based determination of target protease specific cleavage sites from a proteome-based peptide library. It includes a procedure for identifying bespoke PSL sequences, their optimization, synthesis, and validation and introduces a program that can indicate potential cleavage sites by hundreds of enzymes in any arbitrary amino acid sequence. Thereby, we provide an introduction to PSL design, illustrated by the example of matrix metalloproteinase 13 (MMP13). This introduction can serve as a guide and help to greatly accelerate the development and use of protease-sensitive linkers in diverse applications.

show abstract

Bioresponsive drug delivery systems

Cited by 15 publications

References 68 publications

Revolutionizing Wound Healing: Exploring Scarless Solutions through Drug Delivery Innovations

Revolutionizing Wound Healing: Exploring Scarless Solutions through Drug Delivery Innovations

The Emerging Role of Silk Fibroin for the Development of Novel Drug Delivery Systems

An Introductory Guide to Protease Sensitive Linker Design Using Matrix Metalloproteinase 13 as an Example

Contact Info

Product

Resources

About