Bioresponsive nanogated ensemble based on structure-switchable aptamer directed assembly and disassembly of gold nanoparticles from mesoporous silica supports

Zhang, Zhiyong; Runa, A; Wu, Jie; Zhang, Han; Li, Xia; He, Zhiqiang

doi:10.1016/j.cclet.2018.10.019

Cited by 30 publications

(13 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[29][30][31] Simple and sensitive detection of aptamer binding is desirable. [32][33][34][35] Since aptamer binding can fold DNA and hide the bases, [29] the adsorption of aptamer/target complexes to AuNPs is also expected to be slow. Measuring aptamer binding is a challenging task, especially for small molecular targets.…”

Section: Introductionmentioning

confidence: 99%

Label‐Free Colorimetric Biosensors Based on Aptamers and Gold Nanoparticles: A Critical Review

Zhang

Liu

2020

Analysis & Sensing

View full text Add to dashboard Cite

Taking advantage of the adsorption of single‐stranded DNA oligonucleotides by gold nanoparticles (AuNPs) and the protection effect of the adsorbed DNA against salt‐induced aggregation of AuNPs, a label‐free colorimetric sensor for the detection of DNA was reported in 2004. Since then, the range of target molecules has extended from complementary nucleic acids to metal ions and small molecules by using aptamers. In the presence of target molecules, a blue color arising from aggregated AuNPs is expected. However, these sensors only considered aptamer binding to its target, and the adsorption of aptamers by AuNPs, while the target/AuNP interactions were ignored. We recently found that target adsorption can often dominate the system. In this Review, we list literature examples of using this label‐free strategy for sensing aptamer targets. Seven target analytes are discussed in detail. For As(III), dopamine, melamine, kanamycin, adenosine, and ATP, target adsorption dominated, and the same color change was observed even with non‐aptamer sequences. Only in the case of K+ detection, did the effect of specific aptamer binding dominate, attributable to weak K+/AuNP interactions. These examples call for a careful evaluation of target adsorption and the use of non‐aptamer control sequences in validating these sensors.

show abstract

Section: Introductionmentioning

confidence: 99%

Label‐Free Colorimetric Biosensors Based on Aptamers and Gold Nanoparticles: A Critical Review

Zhang

Liu

2020

Analysis & Sensing

View full text Add to dashboard Cite

show abstract

“…Compared with conventional preparations, the metabolic time of nano-transporter drugs in the blood circulation may be prolonged. By regulating pH value (Gao et al, 2018;Yi et al, 2018), temperature (Wei L. et al, 2017), light , ultrasound or biological enzyme (Zhang et al, 2019), the rate of those targeted nano-transporter drugs can be controlled to function longer.…”

Section: Targeting Strategy Of the Nddssmentioning

confidence: 99%

Application of the Nano-Drug Delivery System in Treatment of Cardiovascular Diseases

Deng

Zhang

Shen

et al. 2020

Front. Bioeng. Biotechnol.

192

View full text Add to dashboard Cite

Cardiovascular diseases (CVDs) have become a serious threat to human life and health. Though many drugs acting via different mechanism of action are available in the market as conventional formulations for the treatment of CVDs, they are still far from satisfactory due to poor water solubility, low biological efficacy, non-targeting, and drug resistance. Nano-drug delivery systems (NDDSs) provide a new drug delivery method for the treatment of CVDs with the development of nanotechnology, demonstrating great advantages in solving the above problems. Nevertheless, there are some problems about NDDSs need to be addressed, such as cytotoxicity. In this review, the types and targeting strategies of NDDSs were summarized, and the new research progress in the diagnosis and therapy of CVDs in recent years was reviewed. Future prospective for nano-carriers in drug delivery for CVDs includes gene therapy, in order to provide more ideas for the improvement of cardiovascular drugs. In addition, its safety was also discussed in the review.

show abstract

“…The emergence of nanotechnology has gained more attention, with effective applications appearing in recent years, including biomedical, drug delivery, textiles, agriculture, food industry, cosmetics, and electronics applications [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. Metal nanoparticles (MNPs), including gold, iron, zinc and silver nanoparticles, have been extensively investigated in the last decade [ 10 , 11 , 12 , 13 , 14 , 15 ]. Among them, silver nanoparticles (AgNPs) have emerged as prominent antimicrobial agents due to their unique physicochemical characteristics, chemical stability, and therapeutic, biomolecular detection, and preservative properties [ 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Biomedical Applications of Chinese Herb-Synthesized Silver Nanoparticles by Phytonanotechnology

2021

View full text Add to dashboard Cite

Recent advances in nanotechnology have opened up new avenues for the controlled synthesis of nanoparticles for biomedical and pharmaceutical applications. Chinese herbal medicine is a natural gift to humanity, and it has long been used as an antibacterial and anticancer agent. This study will highlight recent developments in the phytonanotechnological synthesis of Chinese herbal medicines to utilize their bioactive components in biomedical and therapeutic applications. Biologically synthesized silver nanoparticles (AgNPs) have emerged as a promising alternative to chemical and physical approaches for various biomedical applications. The comprehensive rationale of combinational or synergistic effects of Chinese herb-based AgNPs synthesis was investigated with superior physicochemical and biological properties, and their biomedical applications, including antimicrobial and anticancer activity and wound healing properties. AgNPs can damage the cell ultrastructure by triggering apoptosis, which includes the formation of reactive oxygen species (ROS), DNA disintegration, protein inactivation, and the regulation of various signaling pathways. However, the anticancer mechanism of Chinese herbal medicine-based AgNPs is more complicated due to the potential toxicity of AgNPs. Further in-depth studies are required to address Chinese herbs’ various bioactive components and AgNPs as a synergistic approach to combat antimicrobial resistance, therapeutic efficiency of drug delivery, and control and prevention of newly emerged diseases.

show abstract

Bioresponsive nanogated ensemble based on structure-switchable aptamer directed assembly and disassembly of gold nanoparticles from mesoporous silica supports

Cited by 30 publications

References 43 publications

Label‐Free Colorimetric Biosensors Based on Aptamers and Gold Nanoparticles: A Critical Review

Label‐Free Colorimetric Biosensors Based on Aptamers and Gold Nanoparticles: A Critical Review

Application of the Nano-Drug Delivery System in Treatment of Cardiovascular Diseases

Biomedical Applications of Chinese Herb-Synthesized Silver Nanoparticles by Phytonanotechnology

Contact Info

Product

Resources

About