Bioresponsive starPEG-heparin hydrogel coatings on vascular stents for enhanced hemocompatibility

Johnbosco, Castro; Zschoche, Stefan; Nitschke, Mirko; Hahn, Dominik; Werner, Carsten; Maitz, Manfred F.

doi:10.1016/j.msec.2021.112268

Cited by 29 publications

(15 citation statements)

References 37 publications

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“…Ekblad and his colleagues prepared PEGMA copolymer hydrogel coatings on the surface of biomaterials, reducing the sedimentation density of bacteria to less than 5% compared to that on the original surface [81]. Johnbosco Castro et al used a spray coating technique to uniformly distribute a reactive hydrogel precursor on cobaltchromium (CoCr) vascular stents and left the solution polymerizing to form a hydrogel coating [82]. The hydrogel coating is a mixture of four-armed PEG and heparin with disilane and poly (ethylene-alt-maleic anhydride) (PEMA) as a bonding layer, ensuring that the hydrogel coating can provide covalent immobilization on the stent surface.…”

Section: Bacterial Repellence and Inhibitionmentioning

confidence: 99%

Antibacterial-Based Hydrogel Coatings and Their Application in the Biomedical Field—A Review

Peng

Shi

Chen

et al. 2023

JFB

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Hydrogels exhibit excellent moldability, biodegradability, biocompatibility, and extracellular matrix-like properties, which make them widely used in biomedical fields. Because of their unique three-dimensional crosslinked hydrophilic networks, hydrogels can encapsulate various materials, such as small molecules, polymers, and particles; this has become a hot research topic in the antibacterial field. The surface modification of biomaterials by using antibacterial hydrogels as coatings contributes to the biomaterial activity and offers wide prospects for development. A variety of surface chemical strategies have been developed to bind hydrogels to the substrate surface stably. We first introduce the preparation method for antibacterial coatings in this review, which includes surface-initiated graft crosslinking polymerization, anchoring the hydrogel coating to the substrate surface, and the LbL self-assembly technique to coat crosslinked hydrogels. Then, we summarize the applications of hydrogel coating in the biomedical antibacterial field. Hydrogel itself has certain antibacterial properties, but the antibacterial effect is not sufficient. In recent research, in order to optimize its antibacterial performance, the following three antibacterial strategies are mainly adopted: bacterial repellent and inhibition, contact surface killing of bacteria, and release of antibacterial agents. We systematically introduce the antibacterial mechanism of each strategy. The review aims to provide reference for the further development and application of hydrogel coatings.

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Section: Bacterial Repellence and Inhibitionmentioning

confidence: 99%

Antibacterial-Based Hydrogel Coatings and Their Application in the Biomedical Field—A Review

Peng

Shi

Chen

et al. 2023

JFB

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“…All in all, we demonstrated the suitability of pegylated hydrogels as a new method to overcome the Debye length problem in samples with high ionic strength, providing the advantages of such hydrogels to protect the sensor surface from non-specific adsorption and to preserve the activity of antibodies. We predict that the presence of heparin in the gel can be of great importance for future measurements directly in blood samples due to the anticoagulant activity known for starPEG-heparin 55 . Such measurements could help identifying other infectious diseases only detectable in blood or other biomarkers related to various health conditions.…”

Section: Discussionmentioning

confidence: 99%

Hydrogel-gated silicon nanotransistors for SARS-CoV-2 antigen detection in physiological ionic strength

Parichenko

Choi

Shin

et al. 2023

Preprint

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The recent COVID-19 outbreak has strongly pushed the field of biosensors, resulting in multiple new approaches for quantitative virus detection. Among them, those using nanostructured field-effect transistors (FETs) as transducers provide an ultrasensitive approach requiring simple setups for their miniaturization toward point-of-care diagnostics of the disease. However, this type of biosensors suffer from limited sensitivity when it comes to analyzing biofluids due to their shortened screening length in presence of complex liquids with high ionic strength. In this work we propose a solution to this problem, which consists on the surface modification of the FETs with a hydrogel based on star-shaped polyethylene glycol and loaded with specific antibodies against SARS-CoV-2 spike protein. The hydrogel increases the effective Debye length, allowing to preserve the sensitivity in high ionic strength solutions. We provide the demonstration employing silicon nanonet-based FETs for the detection of viral antigens in buffer and in saliva, as well as cultured viral particles. We finally discriminate positive and negative patient samples (nasopharyngeal swab), and propose the theoretical frame that discusses the mechanism of the sensitivity preservation based on the presence of the pegylated hydrogel.

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“…It may be a tendency that the next generation of stents could take the oxidative stress microenvironment by intelligent features that respond to the inflammatory and oxidative stress stimuli with the release of drugs for precise treatment, and simultaneously modulate the oxidative environment to avoid complications of stenting and promote vascular tissue repair . Recently, the application of hydrogel coatings on stent surfaces has started to gain attention. , Compared with conventional coatings, hydrogels have the advantages of high drug loading, easy-to-build intelligent responses, three-dimensional structure that facilitates cell growth, and mechanical states closer to healthy vascular intima . This inspires us that it will be of theoretical importance to construct a new smart hydrogel coating with high binding to vascular stents that respond to ROS for drug release …”

Section: Introductionmentioning

confidence: 99%

Allicin-Loaded Intelligent Hydrogel Coating Improving Vascular Implant Performance

Han,

Lu,

Zou

et al. 2023

ACS Appl. Mater. Interfaces

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Coronary atherosclerosis is closely related to inflammation and oxidative stress. Owing to poor biocompatibility, lack of personalized treatment, and late toxic side effects, traditional drug-eluting stent intervention, releasing antiproliferative drugs, can delay endothelial repair and cause late thrombosis. The inflammation caused by atherosclerosis results in an acidic microenvironment and oxidative stress, which can be considered as triggers for precise and intelligent treatment. Here, we used catechol hyaluronic acid (C-HA) and cystamine (Cys) to prepare C-HA-Cys hydrogel coatings by amide reaction. The H 2 S-releasing donor allicin was loaded in the hydrogel to form an intelligent biomimetic coating. The disulfide bond of Cys made the crosslinked network redox-responsive to the inflammation and oxidative stress in the microenvironment by releasing the drug and H 2 S intelligently to combat the side effects of stent implantation. This study evaluated the hemocompatibility, anti-inflammatory capacity, vascular wall cytocompatibility, and in vivo histocompatibility of this intelligent hydrogel coating. Furthermore, the effect of H 2 S released from the coating on atherosclerosis-related signaling pathways such as CD31 and cystathionine γ-lyase (CSE), CD36, and ACAT-1 was investigated. Our results indicate that the C-HA-Cys-Allicin hydrogel coating could be manufactured on the surface of vascular interventional devices to achieve a precise response to the microenvironment of the lesion to release drug, which can attain the purpose of prevention of in-stent restenosis and ensure the effectiveness and safety of the application of interventional devices.

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Bioresponsive starPEG-heparin hydrogel coatings on vascular stents for enhanced hemocompatibility

Cited by 29 publications

References 37 publications

Antibacterial-Based Hydrogel Coatings and Their Application in the Biomedical Field—A Review

Antibacterial-Based Hydrogel Coatings and Their Application in the Biomedical Field—A Review

Hydrogel-gated silicon nanotransistors for SARS-CoV-2 antigen detection in physiological ionic strength

Allicin-Loaded Intelligent Hydrogel Coating Improving Vascular Implant Performance

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