Biorhythm of arginine-vasopressin in the paraventricular, supraoptic and suprachiasmatic nuclei of rats

Noto, Tadashi; Hashimoto, Hiromichi; Doi, Yasushi; Nakajima, Teruo; Kato, Nobukatsu

doi:10.1016/0196-9781(83)90084-0

Cited by 48 publications

(18 citation statements)

References 18 publications

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“…There is direct and indirect evidence to support the hypothesis that this AVP plays a role in establishing neuroendocrine rhythms. There has been evidence of endogenous rhythmic release of AVP from the SCN in SCN explants (Earnest and Sladek, 1986;Gillette and Reppert, 1987) and rhythmic AVP expression has also been reported (Noto et al, 1983;Yamase et al, 1991;Tominaga et al, 1992).…”

Section: Introductionmentioning

confidence: 93%

Arginine vasopressin (AVP) depletion in neurons of the suprachiasmatic nuclei affects the AVP content of the paraventricular neurons and stimulates adrenocorticotrophic hormone release

et al. 1997

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Arginine vasopressin (AVP) produced in the hypothalamic suprachiasmatic nuclei (SCN) plays a role in establishing neuroendocrine rhythms and, in particular, in regulating the corticotrope axis rhythm. It has recently been shown that AVP from SCN inhibits corticosteroid release. In order to investigate the influence of suprachiasmatic AVP on the different peptidergic systems through the hypothalamus, SCN neurons containing AVP were functionally lesioned by using toxins associated with a cytotoxic monoclonal antibody (MAb) raised against AVP. Six days later, the AVP contents and AVP mRNA were measured in different hypothalamic and extrahypothalamic sites. Adrenocorticotrophic hormone (ACTH) concentration was also measured in plasma. Microinjection of the AVP-MAb/toxin mixture into SCN brought about a significant decrease in the AVP expression in SCN. This is demonstrated by the decrease in the AVP immunoreactive content (24%, P < 0.01) and the decrease of AVP hybridized mRNA (33%, P < 0.01). This points to the efficiency of the microinjection in decreasing the production of AVP in the injection area. Modifications of the AVP contents in the two subdivisions of the hypothalamic paraventricular nucleus (PVN) were also observed. AVP contents decreased in the parvocellular subdivision (pPVN); this is coherent with the AVP depletion in SCN since pPVN is the major site of the SCN hypothalamic efferences. AVP content and AVP mRNA increased in the magnocellular subdivision (mPVN); this also confirms the difference in AVP synthesis regulation according to the PVN subdivisions. The microinjection did not modify AVP expression in supraoptic nuclei or oxytocin (OT) immunoreactive content in the main hypothalamic OT containing sites. Plasma ACTH values were double (P < 0.02) the values measured under non-specific IgG treatment 10 hr after lights on. This probably resulted from the stimulation of the hypothalamo-pituitary-adrenal system since corticotrophin-releasing hormone (CRH) mRNA increased simultaneously by 24% (P < 0.05) in the PVN and the immunoreactive CRH content of the median eminence significantly decreased (26%, P < 0.05). Overall, our data confirm that AVP produced in the SCN inhibits the CRH-adrenocorticotrope axis in normal conditions, probably because of SCN projections of AVP neurons on the PVN.

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Section: Introductionmentioning

confidence: 93%

Arginine vasopressin (AVP) depletion in neurons of the suprachiasmatic nuclei affects the AVP content of the paraventricular neurons and stimulates adrenocorticotrophic hormone release

et al. 1997

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“…Little, however, is known of the changes in circulating oxytocin concentrations in the male rat, although Landgraf, Hacker & Buhl (1982) showed that, in man, the plasma concentration of both these neurohypophysial hormones tended to be higher during the night. Within the hypothalamus, daily variations have been found in the hormonal con¬ tent of the suprachiasmatic nucleus (SCN), supraoptic nucleus (SON) and paraventricular nucleus (PVN) (Noto, Hashomoto, Doi et al 1983). Central release of these hormones also shows daily fluctuation, with concentrations in the cerebrospinal fluid of most species studied being higher during the day (Reppert, 1985).…”

Section: Introductionmentioning

confidence: 99%

Daily rhythms in the hormone content of the neurohypophysial system and release of oxytocin and vasopressin in the male rat: effect of constant light

Windle¹,

Forsling²,

Guzek³

1992

Journal of Endocrinology

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Patterns of neurohypophysial hormone secretion and changes in the hormone content of the hypothalamus and posterior pituitary lobe were monitored in the male rat for cycles of 24 h in association with changes in food and water intake and fluid excretion. Plasma oxytocin and vasopressin concentrations were seen to rise significantly over the hours of daylight, decreasing during the night. Parallel changes were seen in the immunoreactive material in the hypothalamus, whilst the content of the neurohypophysis was inversely related to plasma concentrations. The ratio of plasma oxytocin:vasopressin reached a significant peak at about 02.00 h which might be related to the feeding activity of the rats, food and water intake being largely confined to the night, as was fluid excretion. On exposure to constant light, despite initial disruption hormonal rhythms were still seen but showed a phase shift. The relationships between plasma and tissue levels were maintained. Patterns of food and water intake and urinary excretion were little affected by exposure to constant light, remaining largely confined to the former night phase. The hormonal rhythms appeared to be more closely related to the activity of the rats, which also showed a phase shift during constant light.

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“…In several respects, the SCN functions similarly in nocturnal and diurnal species. Within the SCN of both diurnal and nocturnal mammals, the rates of glucose utilization (Schwartz et al, 1983), levels of immunoreactive (IR) vasopressin (VP; Hofman and Swaab, 1993;Noto et al, 1983), and electrical activity (Inouye and Kawamura, 1979;Sato and Kawamura, 1984;Ruby and Heller, 1996) are higher during the day than at night. In some brain regions outside the SCN, daily rhythms in multiple unit activity and in the expression of Fos peak during the night in nocturnal species and during the day in diurnal species (Inouye and Kawamura, 1979;Sato and Kawamura, 1984;O'Hara et al, 1997).…”

mentioning

confidence: 99%

The suprachiasmatic nucleus and intergeniculate leaflet ofArvicanthis niloticus, a diurnal murid rodent from East Africa

Smale

Boverhof

1999

J. Comp. Neurol.

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Biorhythm of arginine-vasopressin in the paraventricular, supraoptic and suprachiasmatic nuclei of rats

Cited by 48 publications

References 18 publications

Arginine vasopressin (AVP) depletion in neurons of the suprachiasmatic nuclei affects the AVP content of the paraventricular neurons and stimulates adrenocorticotrophic hormone release

Arginine vasopressin (AVP) depletion in neurons of the suprachiasmatic nuclei affects the AVP content of the paraventricular neurons and stimulates adrenocorticotrophic hormone release

Daily rhythms in the hormone content of the neurohypophysial system and release of oxytocin and vasopressin in the male rat: effect of constant light

The suprachiasmatic nucleus and intergeniculate leaflet ofArvicanthis niloticus, a diurnal murid rodent from East Africa

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