Biosafety, stability, and osteogenic activity of novel implants made of Zr70Ni16Cu6Al8 bulk metallic glass for biomedical application

Ida, Hiroto; Seiryu, Masahiro; Takeshita, Nobuo; Iwasaki, Masanari; Yokoyama, Yoshihiko; Tsutsumi, Yusuke; Ikeda, Etsuko; Sasaki, Satoshi; Miyashita, Shuhei; Sasaki, Shutaro; Fukunaga, Tomohiro; Deguchi, Toru; Takano‐Yamamoto, Teruko

doi:10.1016/j.actbio.2018.05.020

Cited by 28 publications

(15 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The implant coating developed in this study imparted both antibacterial and osteoinductive functions that was highly beneficial to allow host cells to interact with the implant surface and inhibit bacterial adhesion . Several strategies have been presented to fabricate antibacterial materials, such as polymer coating, photoactivatable bioactive titanium, antibiotics, and ion implanted materials . We used AgNPs because Ag is readily available with great stability, low cytotoxicity, and broad‐spectrum antibacterial function.…”

Section: Discussionmentioning

confidence: 99%

Effects of Programmed Local Delivery from a Micro/Nano‐Hierarchical Surface on Titanium Implant on Infection Clearance and Osteogenic Induction in an Infected Bone Defect

Shrestha

et al. 2019

Adv Healthcare Materials

View full text Add to dashboard Cite

The two major causes for implant failure are postoperative infection and poor osteogenesis. Initial period of osteointegration is regulated by immunocytes and osteogenic‐related cells resulting in inflammatory response and tissue healing. The healing phase can be influenced by various environmental factors and biological cascade effect. To synthetically orchestrate bone‐promoting factors on biomaterial surface, built is a dual delivery system coated on a titanium surface (abbreviated as AH‐Sr‐AgNPs). The results show that this programmed delivery system can release Ag+ and Sr2+ in a temporal‐spatial manner to clear pathogens and activate preosteoblast differentiation partially through manipulating the polarization of macrophages. Both in vitro and in vivo assays show that AH‐Sr‐AgNPs‐modified surface renders a microenvironment adverse for bacterial survival and favorable for macrophage polarization (M2), which further promotes the differentiation of preosteoblasts. Infected New Zealand rabbit femoral metaphysis defect model is used to confirm the osteogenic property of AH‐Sr‐AgNPs implants through micro‐CT, histological, and histomorphometric analyses. These findings demonstrate that the programmed surface with dual delivery of Sr2+ and Ag+ has the potential of achieving an enhanced osteogenic outcome through favorable immunoregulation.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Programmed Local Delivery from a Micro/Nano‐Hierarchical Surface on Titanium Implant on Infection Clearance and Osteogenic Induction in an Infected Bone Defect

Shrestha

et al. 2019

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…Titanium (Ti) has been successfully used in the field of orthopedic and dental implant due to its excellent physical and biological properties, such as high deformation and fatigue resistance, low specific gravity, and remarkable biocompatibility [1,2]. However, the biological inertia of Ti would inhibit the osseointegration between the metal and bone tissue in some degree [3].…”

Section: Graphical Abstract 1 Introductionmentioning

confidence: 99%

Enhancing antibacterial property of porous titanium surfaces with silver nanoparticles coatings via electron-beam evaporation

Zhang

Luo

et al. 2022

J Mater Sci: Mater Med

View full text Add to dashboard Cite

Antibacterial activity is one of the most vital characteristics for Titanium (Ti) dental implants. Coating antibacterial material onto Ti surfaces is an effective approach to enhance their intrinsic antibacterial ability. However, a cost-effective but efficient coating strategy for realizing this objective still remains challenging. In this study, we proposed a novel implant surface modification strategy for coating silver nanoparticles onto the porous Ti surface via a facile electron beam evaporation (EBE) approach. Porous Ti surfaces were firstly prepared by sand-blasting large grit acid-etching (SLA) process. Then, the silver nanoparticles coating thickness on the porous Ti surface was adjusted and optimized by altering the duration of EBE process. Consequently, composite porous Ti surfaces with different silver thicknesses were synthesized. Polished Ti (PT) surface without SLA or EBE process was also prepared as the controlled blank group. The surface characterizations were analyzed by SEM, AFM, and XPS. After that, the antibacterial properties of all groups were tested with bacteria counting method, bacterial viability test, live/dead bacterial staining, and SEM examination. Results show that silver nanoparticles were uniformly distributed on the porous Ti surfaces after the SLA and EBE processes. After being incorporated with silver nanoparticles, the composite surfaces successfully inhibited the growth of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The antibacterial ratio (AR) values of SLA-Ag groups increased with the increasing silver thickness and are significantly higher than those of PT and SLA groups. Therefore, by the SLA and EBE processes, the composite porous Ti surfaces modified with silver nanoparticles coatings demonstrate superior antibacterial property compared with pure Ti surfaces, which is highly promising for enhancing the antibacterial functions of dental implants.

show abstract

“…[1][2][3][4][5][6][7] Besides, due to their minimal stress shielding and anti-biocorrosion, biocompatibility with the promotion of cell adhesion, and in some cases, biodegradability, these advanced amorphous alloys have started to be used in daily healthcare applications such as orthopedics and dental implants, screws for bone fracture fixation, and stents for cardiovascular repair. [8][9][10][11][12][13][14][15] Promising antimicrobial properties of thin film metallic glass (TFMG) coatings have been shown in the literature. [16][17][18][19][20][21][22] Biocompatible flexible metallic films were suggested to be used in smart windows, microfluidic channels, and antifouling coatings by adjusting the pattern of the wrinkled structure to achieve a dynamically tunable transmittance and wetting behavior [23] .…”

Section: Introductionmentioning

confidence: 99%

Magnetron Sputtered Non‐Toxic and Precious Element‐Free TiZrGe Metallic Glass Nanofilms with Enhanced Biocorrosion Resistance

Sarac

Mičušík

Pütz

et al. 2022

Adv Materials Inter

View full text Add to dashboard Cite

The chemical composition and structural state of advanced alloys are the decisive factors in optimum biomedical performance. This contribution presents unique Ti-Zr-Ge metallic glass thin-film compositions fabricated by magnetron sputter deposition targeted for nanocoatings for biofouling prevention. The amorphous nanofilms with nanoscale roughness exhibit a large relaxation and supercooled liquid regions as revealed by flash differential scanning calorimetry. Ti68Zr8Ge24 shows the lowest corrosion (0.17 µA cm -2 ) and passivation (1.22 µA cm -2 ) current densities, with the lowest corrosion potential of -0.648 V and long-range stability against pitting, corroborating its excellent performance in phosphate buffer solution at 37 °C. The oxide layer is comprised of TiO2, TiOx and ZrOx, as determined using X-ray photoelectron spectroscopy by short-term ion-etching of the surface layer. The two orders of magnitude increase in the oxide and interface resistance (from 14 to 1257 Ω cm 2 ) along with an order of magnitude decrease in the capacitance parameter of the oxide interface (from 1.402  10 -5 to 1.677  10 -6 S s n cm -2 ) of the same composition is linked to the formation of carbonyl groups and reduction of the native oxide layer during linear sweep voltammetry. 4(21-25 at.%) were produced using magnetron sputter deposition and examined thoroughly using structural, thermal, morphological, compositional and electrochemical methods. Results and Discussion Structural, Thermal, and Optical PropertiesThe amorphous nature of the as-sputtered samples was checked using grazing incidence Xray diffraction (Figure 1a). The broad amorphous diffraction maximum shifts from ~37.8° to ~38.6° as the amount of Ti in the TiNFs increases. Although the second broad hump is barely distinguishable for all the samples (between 65° and 85°), the determination of the peak

show abstract

Biosafety, stability, and osteogenic activity of novel implants made of Zr70Ni16Cu6Al8 bulk metallic glass for biomedical application

Cited by 28 publications

References 65 publications

Effects of Programmed Local Delivery from a Micro/Nano‐Hierarchical Surface on Titanium Implant on Infection Clearance and Osteogenic Induction in an Infected Bone Defect

Effects of Programmed Local Delivery from a Micro/Nano‐Hierarchical Surface on Titanium Implant on Infection Clearance and Osteogenic Induction in an Infected Bone Defect

Enhancing antibacterial property of porous titanium surfaces with silver nanoparticles coatings via electron-beam evaporation

Magnetron Sputtered Non‐Toxic and Precious Element‐Free TiZrGe Metallic Glass Nanofilms with Enhanced Biocorrosion Resistance

Contact Info

Product

Resources

About