Biosensing strategies (approaches) for diagnosis and monitoring of multiple sclerosis

Serin, Marina; Kara, Pınar

doi:10.1016/j.talanta.2022.123794

Cited by 8 publications

(4 citation statements)

References 100 publications

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“…Multiple sclerosis (MS) is a chronic autoimmune disease characterized by inflammation, neurodegeneration, and demyelination of the central nervous system (CNS). It is frequently diagnosed in women aged 20 to 40, although it can affect individuals of all genders, including children and the elderly [ 36 ]. MS is principally developed by both genetic predisposition and environmental factors.…”

Section: Autoimmune Diseases and Their Biomarkersmentioning

confidence: 99%

“…It induces the destruction of myelin sheaths and myelin-producing oligodendrocytes, thereby leading to the injury and degeneration of demyelinated axons. In these areas where the myelin sheath is damaged, sclerosis (hardened tissues) appear and occur at various positions within the CNS, thus hindering the transmission of electrical signals along the nerves [ 36 , 37 , 38 ]. This process can be manifests clinically through physical disability, cognitive impairment, and other symptoms that affect quality of life [ 39 ].…”

Section: Autoimmune Diseases and Their Biomarkersmentioning

confidence: 99%

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Recent Advances in Biosensors for Diagnosis of Autoimmune Diseases

Teniou,

Rhouati,

Marty

2024

Sensors

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Over the last decade, autoimmune diseases (ADs) have undergone a significant increase because of genetic and/or environmental factors; therefore, their simple and fast diagnosis is of high importance. The conventional diagnostic techniques for ADs require tedious sample preparation, sophisticated instruments, a dedicated laboratory, and qualified personnel. For these reasons, biosensors could represent a useful alternative to these methods. Biosensors are considered to be promising tools that can be used in clinical analysis for an early diagnosis due to their high sensitivity, simplicity, low cost, possible miniaturization (POCT), and potential ability for real-time analysis. In this review, recently developed biosensors for the detection of autoimmune disease biomarkers are discussed. In the first part, we focus on the main AD biomarkers and the current methods of their detection. Then, we discuss the principles and different types of biosensors. Finally, we overview the characteristics of biosensors based on different bioreceptors reported in the literature.

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Section: Autoimmune Diseases and Their Biomarkersmentioning

confidence: 99%

Section: Autoimmune Diseases and Their Biomarkersmentioning

confidence: 99%

Recent Advances in Biosensors for Diagnosis of Autoimmune Diseases

Teniou,

Rhouati,

Marty

2024

Sensors

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“…Several review articles have presented biosensors/immunosensors for ADs, some of which deal only with electrochemical sensors, while others present information on sensors based on more types of signal transduction [ 1 , 3 , 24 , 36 ]. Some recent reviews have described biosensors/immunosensors proposed to serve diagnosis of specific ADs, such as MS [ 37 , 38 ] and RA [ 39 ], while other review papers have focused on biosensors/immunosensors for the detection of specific AD-related biomarkers, such as IL-6 [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Immunosensors for Autoimmune-Disease-Related Biomarkers: A Literature Review

Karachaliou

Livaniou

2023

Sensors

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Immunosensors are a special class of biosensors that employ specific antibodies for biorecognition of the target analyte. Immunosensors that target disease biomarkers may be exploited as tools for disease diagnosis and/or follow-up, offering several advantages over conventional analytical techniques, such as rapid and easy analysis of patients’ samples at the point-of-care. Autoimmune diseases have been increasingly prevalent worldwide in recent years, while the COVID-19 pandemic has also been associated with autoimmunity. Consequently, demand for tools enabling the early and reliable diagnosis of autoimmune diseases is expected to increase in the near future. To this end, interest in immunosensors targeting autoimmune disease biomarkers, mainly, various autoantibodies and specific pro-inflammatory proteins (e.g., specific cytokines), has been rekindled. This review article presents most of the immunosensors proposed to date as potential tools for the diagnosis of various autoimmune diseases, such as type 1 diabetes, rheumatoid arthritis, and multiple sclerosis. The signal transduction and the immunoassay principles of each immunosensor have been suitably classified and are briefly presented along with certain sensor elements, e.g., special nano-sized materials used in the construction of the immunosensing surface. The main concluding remarks are presented and future perspectives of the field are also briefly discussed.

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“…To create polyclonal antibodies, an antigen is injected into an animal that has an immune response, after which they are collected directly from the serum and purified. They can be used as markers for diagnosing chronic [8], neurodegenerative [9,10], oncological [11] and infectious [12] diseases, etc. Traditional methods for the detection of protein biomarkers, such as immunoassays (ELISA, immunochemiluminescent assays), despite their high sensitivity and selectivity, are expensive, time-consuming and multi-stage procedures performed in specialized diagnostic laboratories [13].…”

Section: Introductionmentioning

confidence: 99%

Impedimetric Biosensor Coated with Zinc Oxide Nanorods Synthesized by a Modification of the Hydrothermal Method for Antibody Detection

et al. 2023

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Impedimetric biosensors are used for detecting a wide range of analytes. The detection principle is a perspective for the development of new types of analytical devices for biomolecular diagnosis of diseases. Of particular interest are biosensors with very high sensitivities, capable of detecting trace amounts of biomarkers or drugs in biological fluids. Impedimetric biosensors possess a potential for increased sensitivity, since their electrodes can be modified with nanostructured materials, in particular zinc oxide. In this work, a miniature biosensor with an array of zinc oxide nanorods synthesized by the hydrothermal method has been created. Protein A was immobilized on the resulting structure, which was previously tested for binding to omalizumab by capillary electrophoresis. Using impedance spectroscopy, it was possible to detect the binding of omalizumab at concentrations down to 5 pg/mL. The resulting structures are suitable for creating reusable biosensor systems, since ZnO-coated electrodes are easily cleaned by photocatalytic decomposition of the bound molecules. The biosensor is promising for use in Point-of-Care systems designed for fast, multimodal detection of molecular markers of a wide range of diseases.

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Biosensing strategies (approaches) for diagnosis and monitoring of multiple sclerosis

Cited by 8 publications

References 100 publications

Recent Advances in Biosensors for Diagnosis of Autoimmune Diseases

Recent Advances in Biosensors for Diagnosis of Autoimmune Diseases

Immunosensors for Autoimmune-Disease-Related Biomarkers: A Literature Review

Impedimetric Biosensor Coated with Zinc Oxide Nanorods Synthesized by a Modification of the Hydrothermal Method for Antibody Detection

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