Biosensor Economics and Manufacturing

Organoelement Coatings on Glass as Precursors for Biochip Technologies

“…Currently, for manufacturing biochips it is common to use glass, relative chemical inertness and the possibility of functionalization of which make it a convenient material to allow the molecule consolidation on its surface . Immobilization of biomolecules on the glass surface is possible after chemical modification, including the generation of free silanol groups, and treatment with organic compounds to form reactive functional groups on the surface …”

“…[1,2] Currently, for manufacturing biochips it is common to use glass, relative chemical inertness and the possibility of functionalization of which make it a convenient material to allow the molecule consolidation on its surface. [3] Immobilization of biomolecules on the glass surface is possible after chemical modification, including the generation of free silanol groups, and treatment with organic compounds to form reactive functional groups on the surface. [4,5] The molecular assembly of micro-and nanosized molecular and macromolecular structures from functional organoelement compounds (including organosilicon compounds) on the polymer surface allows the targeted control of the molecular structure and properties of surface layers.…”