Biosensor Microsystems

Urban, G.

doi:10.1002/1616-8984(200011)8:1<189::aid-seup189>3.0.co;2-a

Cited by 8 publications

(3 citation statements)

References 75 publications

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“…The use of carbon fibers for SH immobilization was applied in the development of biosensors for in situ analysis. Furthermore, the architecture of this microelectrode defined the level of sensitivity and stability (Carvalho et al, 2000 and2001).…”

Section: Salicylatesmentioning

confidence: 99%

“…The electrochemical methods are especially useful in the study of neurotransmitters (NT) and neuronal drugs, not only from a quality control point of view, but also for physiological purposes. Voltammetry coupled to microelectrodes modified with drug or NT receptors are a useful tool for evaluating the physiopathological process, elucidating their pharmacological mechanism of action, as well as for the development of new drugs (Crespi, 1995;Urban, 2001;Crespi, 2002).…”

Section: Neurotransmitters Drugsmentioning

confidence: 99%

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Electrochemical biosensors in pharmaceutical analysis

Gil

Melo

2010

Braz. J. Pharm. Sci.

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Given the increasing demand for practical and low-cost analytical techniques, biosensors have attracted attention for use in the quality analysis of drugs, medicines, and other analytes of interest in the pharmaceutical area. Biosensors allow quantification not only of the active component in pharmaceutical formulations, but also the analysis of degradation products and metabolites in biological fluids. Thus, this article presents a brief review of biosensor use in pharmaceutical analysis, focusing on enzymatic electrochemical sensors.
Em virtude do aumento da demanda por técnicas analíticas simples e de baixo custo, os biossensores têm atraído a atenção para a análise de fármacos, medicamentos e outros analitos de interesse em controle de qualidade de medicamentos. Os biossensores permitem a quantificação não somente de princípio ativo em formulações farmacêuticas, mas também de produtos de degradação e metabólitos em fluídos biológicos, bem como análise de amostras de interesse clínico e industrial, além de possibilitar a determinação de enantiômeros. Desta forma, este artigo objetiva fazer uma breve revisão a respeito do emprego de biossensores em análise farmacêutica, com ênfase em sensores eletroquímicos enzimáticos

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Section: Salicylatesmentioning

confidence: 99%

Section: Neurotransmitters Drugsmentioning

confidence: 99%

Electrochemical biosensors in pharmaceutical analysis

Gil

Melo

2010

Braz. J. Pharm. Sci.

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“…A very fast response signal can be observed with a short analysis time. Recently, microfluidic devices have been incorporated with various biological materials such as enzymes, immunological materials, DNA and whole cells to prepare bioanalytical systems 3–6. Moreover, it is well known that enzymes carry out a vast range of chemical transformations; enzyme assays make these enzymatic transformations visible 7.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic devices and true‐color sensor as platform for glucose oxidase and laccase assays

Demirkol

Dornbusch²,

Feller³

et al. 2011

Engineering in Life Sciences

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The commonly used assay for measuring glucose oxidase (GOx) and laccase (Lac) activity, based on spectrophotometric test using 2,2′‐azinobis‐(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS), has been adapted to measure these enzyme activities via microfluidic devices. The effects of flow rate and concentration of substrates were examined. The developed assays allowed analyzing GOx and Lac activities in the range of 0.8–8.0 Unit (0.1–1.0 mg/mL) and 0.9–17.7 Unit (0.1–2.0 mg/mL), respectively. Moreover, repeatability tests were obtained for both enzyme assays.

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Thermal Biosensor and Microbiosensor Techniques

Xie

Danielsson

2007

Handbook of Biosensors and Biochips

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This chapter describes principles and features of thermal biosensors and microbiosensors and includes a discussion of different thermal transducers. A number of instrumental concepts are described in detail from larger flow injection instruments to miniaturized devices and chip designs with thermal arrays. A thermal–electrochemical hybrid sensor is also presented. The chapter contains many descriptions of actual assays from different fields, such as process and in vivo monitoring, multianalyte determination, operation in organic solvents, and environmental analysis.

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Biosensor Microsystems

Cited by 8 publications

References 75 publications

Electrochemical biosensors in pharmaceutical analysis

Electrochemical biosensors in pharmaceutical analysis

Microfluidic devices and true‐color sensor as platform for glucose oxidase and laccase assays

Thermal Biosensor and Microbiosensor Techniques

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