Biosensors Based on Inorganic Composite Fluorescent Hydrogels

Sokolov, Pavel M.; Samokhvalov, Pavel; Sukhanova, Alyona; Nabiev, Igor

doi:10.3390/nano13111748

Cited by 3 publications

(2 citation statements)

References 102 publications

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“…Hydrogels have been widely investigated as biosensors for detecting specific biomolecules like proteins or DNA [130,131]. Numerous studies have developed hydrogel-based biosensors capable of detecting biomolecules by modulating properties such as color, fluorescence, and conductivity.…”

Section: Biosensorsmentioning

confidence: 99%

Enhanced Surface Immunomodification of Engineered Hydrogel Materials through Chondrocyte Modulation for the Treatment of Osteoarthritis

Yao,

Huo,

et al. 2024

Coatings

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Osteoarthritis (OA) is characterized by cartilage degeneration and synovial inflammation, with chondrocytes playing a pivotal role in this disease. However, inflammatory mediators, mechanical stress, and oxidative stress can compromise functionality. The occurrence and progression of OA are intrinsically linked to the immune response. Current research on the treatment of OA mainly concentrates on the synergistic application of drugs and tissue engineering. The surface of engineered hydrogel materials can be immunomodified to affect the function of chondrocytes in drug therapy, gene therapy, and cell therapy. Prior studies have concentrated on the drug-loading function of hydrogels but overlooked the immunomodulatory role of chondrocytes. These modifications can inhibit the proliferation and differentiation of chondrocytes, reduce the inflammatory response, and promote cartilage regeneration. The surface immunomodification of engineered hydrogel materials can significantly enhance their efficacy in the treatment of OA. Thus, immunomodulatory tissue engineering has significant potential for treating osteoarthritis.

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Section: Biosensorsmentioning

confidence: 99%

Enhanced Surface Immunomodification of Engineered Hydrogel Materials through Chondrocyte Modulation for the Treatment of Osteoarthritis

Yao,

Huo,

et al. 2024

Coatings

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“…Hydrogels can detect low concentrations of biomarkers and visually monitor changes in fluorescence intensity, signaling alterations within the body. 490 The flexibility, scalability, adhesiveness, and self-healing properties of hydrogel sensors render them highly promising for health monitoring applications. They can adjust to various dynamic changes in the body and through innovative design, achieve precise health status monitoring and data transmission.…”

Section: Hydrogels For Non-cell Therapymentioning

confidence: 99%

Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Lu,

Ruan,

Huang

et al. 2024

Sig Transduct Target Ther

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The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements and the potential of hydrogels in therapeutic applications, focusing primarily on two areas: emerging cell-based therapies and promising non-cell therapeutic modalities. Within the context of cell therapy, we discuss the capacity of hydrogels to overcome the existing translational challenges faced by mainstream cell therapy paradigms, provide a detailed discussion on the advantages and principal design considerations of hydrogels for boosting the efficacy of cell therapy, as well as list specific examples of their applications in different disease scenarios. We then explore the potential of hydrogels in drug delivery, physical intervention therapies, and other non-cell therapeutic areas (e.g., bioadhesives, artificial tissues, and biosensors), emphasizing their utility beyond mere delivery vehicles. Additionally, we complement our discussion on the latest progress and challenges in the clinical application of hydrogels and outline future research directions, particularly in terms of integration with advanced biomanufacturing technologies. This review aims to present a comprehensive view and critical insights into the design and selection of hydrogels for both cell therapy and non-cell therapies, tailored to meet the therapeutic requirements of diverse diseases and situations.

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Nanocomposite hydrogel fibers in the field of diagnosis and treatment

Yu,

Wang,

2023

AIMSMATES

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<abstract> <p>In the past few decades, many researchers have focused their research interests on nanocomposite hydrogel fibers (NHFs). These practitioners have developed and optimized techniques for preparing nanofiber membranes such as the template method, microfluidic spinning, electrospinning, wet spinning and three-dimensional printing (3D printing). NHFs have important applications in wearable monitoring, diagnosis and nursing due to their various excellent properties (such as high-water content, porous morphology, flexibility, braiding and rich active functional groups). In this paper, the latest progress of NHFs in pose monitoring, continuous monitoring of physiological indicators, diagnosis, wearables, nursing, drug delivery and dressings are reviewed. This paper also aims to review their key operational parameters, advantages and disadvantages of NHFs in the above fields, including sensitivity, working range and other special properties. Specifically, NHFs can be used for continuous monitoring of biological postures (such as gestures) or physiological indicators (such as blood sugar) <italic>in vitro</italic> and <italic>in vivo</italic>. NHFs also can be used for long-term monitoring of related indicators in the wearable field. NHFs can be used in tissue engineering and drug delivery. Finally, we look forward to the development prospects, challenges and opportunities of the next generation of NHFs. We confirm that the emergence of NHFs in the field of diagnosis and treatment has opened up a new vision for human health. Researchers have optimized the template method, microfluidic spinning, electrospinning, wet spinning and 3D printing.</p> </abstract>

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Biosensors Based on Inorganic Composite Fluorescent Hydrogels

Cited by 3 publications

References 102 publications

Enhanced Surface Immunomodification of Engineered Hydrogel Materials through Chondrocyte Modulation for the Treatment of Osteoarthritis

Enhanced Surface Immunomodification of Engineered Hydrogel Materials through Chondrocyte Modulation for the Treatment of Osteoarthritis

Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Nanocomposite hydrogel fibers in the field of diagnosis and treatment

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