Biosensors for biomarkers in medical diagnostics

Mascini, Marcello; Tombelli, Sara

doi:10.1080/13547500802645905

Cited by 175 publications

(92 citation statements)

References 87 publications

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“…Since there is no single oncogen that is altered in each type of cancer, several biosensors detecting different biomarkers were developed. These biosensors are able to detect prostate specific antigen (PSA), carcinoembryonic antigen (CEA), afetoprotein (AFP), epidermal growth factor-2 (HER-2), interleukin-6 (IL-6), and interleukin-8 (IL-8) [55]. Respiratory insufficiency can also be monitored with help of lactate biosensor based on lactate oxidase enzyme [56].…”

Section: Clinical Significance Of Polymer-based Biosensorsmentioning

confidence: 99%

Perspective potential of polymer-based biosensor chips in food industry and clinical diagnostics

Mehmedinovi¹,

Ibriimovi²,

Kesi³

et al. 2017

Biodegradable Polymers: Recent Developments and New Perspectives

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Section: Clinical Significance Of Polymer-based Biosensorsmentioning

confidence: 99%

Perspective potential of polymer-based biosensor chips in food industry and clinical diagnostics

Mehmedinovi¹,

Ibriimovi²,

Kesi³

et al. 2017

Biodegradable Polymers: Recent Developments and New Perspectives

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“…thrombin, C-reactive protein, troponin, and so far. Moreover, this could reduce hospital expenses and would be very beneficiary for treatment of patient [10].…”

Section: Clinical Diagnosismentioning

confidence: 99%

Emerging Trends in Medical Diagnosis: A Thrust on Nanotechnology

SH¹

2014

Med chem

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Nanotechnology is the manipulation of material on an atomic and molecular scale; by changing its physical, chemical and biological properties to produce novel materials, devices, and systems. Nanomaterials exhibit remarkable characteristics such as high surface to volume ratio, catalytic activity, and biocompatibility which make them suitable for various biomedical applications. Nanotechnology have prospective to improve the whole healthcare process for patient; starts from diagnosis to treatment and follow-up monitoring. Medical diagnosis based on nanotechnology provides two major advantages: rapid testing and early diagnosis. The potential contributions of nanotechnology in the medical diagnosis are extremely broad and improve traditional diagnostic tools and methods in the field of clinical diagnosis, imaging and electro-diagnosis. Emerging modalities such as biochip, microarray, nanobarcode, micro-electromechanical systems, lab on chip and nanobiosensor have revolutionized the field of medical diagnosis. Nanoscale materials and nano-enabled techniques are used for diagnosis of various diseases such as cardiovascular diseases, cancer, diabetes, infectious disease, musculoskeletal and neurodegenerative disease etc. Among all medical applications of nanotechnology, nanobiosensor especially enzyme nanobiosensor are sensitive, reliable, robust, reproducible and cost effective diagnostic tool to meet the requirements of healthcare.

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“…In this paper the current state and future trends of biosensors are presented. Also Mascini et al [3] reviewed the application of biosensor sin medical diagnostics, taking into account several crucial features.…”

Section: Introductionmentioning

confidence: 99%

“…The earlier biosensors were catalytic systems that integrated especially enzymes with transducers that converted the biological response into an electronic signal. The next generation of biosensors, took advantage of different biological elements, such as antibodies, receptors (natural or synthetic), or nucleic acids [3] [4].…”

Section: Introductionmentioning

confidence: 99%

Reliable Method for Steady-State Concentrations and Current over the Diagnostic Biosensor Transducers

Preethi¹,

Meena²,

Poovazhaki³

2017

AJAC

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A mathematical modelling of diagnostic biosensors system at three basic types of enzyme kinetics is discussed in the presence of diffusion. Enzyme kinetics is adopted to be first order, Michaelis-Menten and ping-pong mechanism. In this paper, approximate analytical solutions are obtained for the non-linear equations under steady-state conditions by using the new Homotopy perturbation method. Simple and closed forms of analytical expressions for concentrations of substrate, product and co-substrate and corresponding current response have been derived for all possible values of parameters. Furthermore, the numerical simulation of the problem is also reported here by using Matlab program. Good agreement between analytical and numerical results is noted.

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Biosensors for biomarkers in medical diagnostics

Cited by 175 publications

References 87 publications

Perspective potential of polymer-based biosensor chips in food industry and clinical diagnostics

Perspective potential of polymer-based biosensor chips in food industry and clinical diagnostics

Emerging Trends in Medical Diagnosis: A Thrust on Nanotechnology

Reliable Method for Steady-State Concentrations and Current over the Diagnostic Biosensor Transducers

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