Biosensors for waterborne viruses: Detection and removal

Altıntaş, Zeynep; Gittens, Micah; Pocock, Jack; Tothill, Ibtisam E.

doi:10.1016/j.biochi.2015.05.010

Cited by 54 publications

(43 citation statements)

References 112 publications

(139 reference statements)

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“…This is because they can be developed inexpensively into sensitive, specific and easy-to-operate tools. They can also give very rapid readings, saving hours of sample analysis time compared to conventional methods (Altintas et al 2015). The application of nanomaterials such as quantum dots, carbon nanotubes and smart nanostructures for the detection of indicator organisms using biosensors also plays an important role in increasing the sensitivity and capacity of these platforms.…”

Section: Emerging Methodsmentioning

confidence: 99%

Assessment of the microbiological quality of recreational waters: indicators and methods

Rodrigues

Cunha

2017

Euro-Mediterr J Environ Integr

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The microbiological quality of recreational waters (RW) has been assessed through the use of microbial indicators. Usually, three typical fecal bacteria, namely fecal coliforms, Escherichia coli and Enterococcus spp., are deemed by legislation and regulatory agencies for routine monitoring of the fecal contamination in RW. However, these traditional indicators have some limitations, as they underestimate health risks and do not determine the sources of contamination. Currently, the increasing concern with the minimization of human health risks associated with recreational water use and the protection of water resources outweigh the actual normative perspective. The potentials and limitations of conventional and alternative fecal contamination detection systems must be carefully evaluated, taking into account the specificities of each recreational water body and the natural or anthropogenic sources of environmental variability. The careful choice of analysis for detection and quantification of indicators in the light of their potential and shortcomings is of major importance for the timely evaluation of risks and implementation of strategies that effectively protect users and preserve water quality. This paper presents a critical literature review of the traditional and innovative methodologies for the analysis of fecal indicators in recreational water and intends to discuss their contribution for the management of the microbiological quality and safety of leisure surface waters.

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Section: Emerging Methodsmentioning

confidence: 99%

Assessment of the microbiological quality of recreational waters: indicators and methods

Rodrigues

Cunha

2017

Euro-Mediterr J Environ Integr

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“…Despite of structural and natural similarity between MS2 phage and adenovirus, their size and also Vancomycin Control template to imprint MS2 phage Control virus template to imprint coating materials are quite different. MS2 phage is 25 nm whereas adenovirus is 90 nm (Altintas et al, 2015a). In this study, we aimed to compare these two different MIPs (MS2-MIP and vancomycin-MIP) with our target MIP to see the effect of receptors characteristics.…”

Section: Spr Detection Of Adenovirus Using Plastic Antibodiesmentioning

confidence: 99%

“…They also demonstrate high affinity for their target and have a proven, successful track record of implementation into reliable, effective and portable biosensor systems, such as in pregnancy tests (Hu et al, 2014). However, their maintenance can be difficult, they can be very expensive (Tothill, 2009), are prone to oxidative/ microbial degradation and are unusable in harsh environments such as strong acidic/basic conditions or organic solvents (Altintas et al, 2015a). An alternative to antibodies circumventing these factors is the use of molecularly imprinted polymers (MIPs).…”

Section: Introductionmentioning

confidence: 96%

Comparative investigations for adenovirus recognition and quantification: Plastic or natural antibodies?

Altıntaş

Pocock

Thompson

et al. 2015

Biosensors and Bioelectronics

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“…The multistep procedures of virus separation, concentration and purification are of great importance for the preparation of the products containing a virus as the principal component, such as cell culturederived virus stocks for vaccine manufacturing, research and gene therapy [1][2][3][4]. On the other hand, virus separation is also required during procedures involving virus removal such as preparation of biopharmaceutical products, which should be free of any viral contamination [5] and in the purification of drinking water from water-borne viruses such as hepatitis A virus, hepatitis E virus, norovirus, rotavirus, and adenovirus [6].…”

Section: Introductionmentioning

confidence: 99%

Biopolymeric nano/microspheres for selective and reversible adsorption of coronaviruses

Ciejka

Wolski

Nowakowska

et al. 2017

Materials Science and Engineering: C

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A novel biopolymeric material in the form of nano/microspheres was developed which was capable of adsorbing coronaviruses. The biopolymer was obtained by crosslinking of chitosan (CHIT) with genipin, a nontoxic compound of plant origin, in inverted emulsion and reacting the chitosan nano/microspheres obtained (CHIT-NS/MS) with glycidyltrimethyl-ammonium chloride (GTMAC). As a result the nano/microspheres of N-(2-hydroxypropyl)-3-trimethyl chitosan (HTCC-NS/MS) were obtained. HTCC-NS/MS were studied as the adsorbents of human coronavirus NL63 (HCoV-NL63), mouse hepatitis virus (MHV), and human coronavirus HCoV-OC43 particles in aqueous virus suspensions. By studying cytopathic effect (CPE) caused by these viruses and performing PCR analyses it was found HTCC-NS/MS strongly adsorb the particles of HCoV-NL63 virus, moderately adsorb mouse hepatitis virus (MHV) particles, but do not adsorb HCoV-OC43 coronavirus. The adsorption capacity of HTCC-NS/MS well correlated with the antiviral activity of soluble HTCC against a given virus. Importantly, it was shown that HCoV-NL63 particles could be desorbed from the HTCC-NS/MS surface with a salt solution of high ionic strength with retention of virus virulence. The obtained material may be applied for the removal of coronaviruses, purification and concentration of virus samples obtained from biological matrices and for purification of water from pathogenic coronaviruses.

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Biosensors for waterborne viruses: Detection and removal

Cited by 54 publications

References 112 publications

Assessment of the microbiological quality of recreational waters: indicators and methods

Assessment of the microbiological quality of recreational waters: indicators and methods

Comparative investigations for adenovirus recognition and quantification: Plastic or natural antibodies?

Biopolymeric nano/microspheres for selective and reversible adsorption of coronaviruses

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