Biosensors; noninvasive method in detection of C-reactive protein  (CRP)

Khanmiri, Hamidreza Hassanzadeh; Yazdanfar, Fatemeh; Mobed, Ahmad; Rezamohammadi, Fatemeh; Rahmani, Mehrnoush; Haghgouei, Tannaz

doi:10.1007/s10544-023-00666-y

Cited by 10 publications

(3 citation statements)

References 47 publications

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“…43,44 There are several innovative methods developed for the detection of CRP with varying degrees of sensitivity. 44,45 The plasmonic ELISA utilizes etched Ag-coated Au nanobipyramids for multicolorimetric detection and achieves an LOD of 0.09 ng/ mL. 46 The fluorescent fullerene nanoparticle-based LFIA can detect CRP concentrations between 0.1 and 10 ng/mL in serum in just 15 min.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Currently, the detection limit of CRP in conventional enzyme-linked immunosorbent assay (ELISA) can reach the level of 0.1 ng/mL. , There are several innovative methods developed for the detection of CRP with varying degrees of sensitivity. , The plasmonic ELISA utilizes etched Ag-coated Au nanobipyramids for multicolorimetric detection and achieves an LOD of 0.09 ng/mL . The fluorescent fullerene nanoparticle-based LFIA can detect CRP concentrations between 0.1 and 10 ng/mL in serum in just 15 min .…”

Section: Resultsmentioning

confidence: 99%

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Improving Sensitivity and Reproducibility of Surface-Enhanced Raman Scattering Biochips Utilizing Magnetoplasmonic Nanoparticles and Statistical Methods

Lin,

Chen,

Huang

et al. 2024

ACS Sens.

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Surface-enhanced Raman scattering (SERS) technology has been widely recognized for its remarkable sensitivity in biochip development. This study presents a novel sandwich immunoassay that synergizes SERS with magnetoplasmonic nanoparticles (MPNs) to improve sensitivity. By taking advantage of the unique magnetism of these nanoparticles, we further enhance the detection sensitivity of SERS biochips through the applied magnetic field. Despite the high sensitivity, practical applications of SERS biochips are often limited by the issues of stability and reproducibility. In this study, we introduced a straightforward statistical method known as "Gaussian binning", which involves initially binning the two-dimensional Raman mapping data and subsequently applying Gaussian fitting. This approach enables a more consistent and reliable interpretation of data by reducing the variability inherent in Raman signal measurements. Based on our method, the biochip, targeting for C-reactive protein (CRP), achieves an impressive detection limit of 5.96 fg/mL, and with the application of a 3700 G magnetic field, it further enhances the detection limit by 5.7 times, reaching 1.05 fg/mL. Furthermore, this highly sensitive and magnetically tunable SERS biochip is easily designed for versatile adaptability, enabling the detection of other proteins. We believe that this innovation holds promise in enhancing the clinical applicability of SERS biochips.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Improving Sensitivity and Reproducibility of Surface-Enhanced Raman Scattering Biochips Utilizing Magnetoplasmonic Nanoparticles and Statistical Methods

Lin,

Chen,

Huang

et al. 2024

ACS Sens.

View full text Add to dashboard Cite

show abstract

“…Currently, common detection methods include fluorescence [53, 54], electrochemical [55, 56], colorimetric [57, 58], and capillary electrophoresis [59, 60]. Although the above methods can provide accurate detection in diagnosis, they all have more limitations, such as complex and expensive instruments, high requirements for operating techniques, or time‐consuming tests [61–63]. And the cost of providing health care in centralized facilities, such as hospitals, is increasing [64, 65].…”

Section: Introductionmentioning

confidence: 99%

Recent advances on portable photoelectrochemical biosensors for diagnostics

Wu,

Tang

2023

Electroanalysis

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Efficient and accurate diagnostic methods are important for human health monitoring and prevention of major diseases, so the establishment of efficient and convenient testing methods for clinical diagnosis is urgent. Photoelectrochemical (PEC) biosensors have attracted much attention because of their high sensitivity, low detection background, and especially the advantages of combining photoexcitation and electrochemical detection. With the rapid development of integrated circuit technology many wireless transmissions of highly aggregated portable micro devices are manufactured, its small size, easy to carry, and the ability to visualize the results of the test is shown to be the potential for the application of such devices. This review aims to cover recent advances in PEC biosensing within the field of portable detection, including the principles of PEC biosensors, common photovoltaic materials, and scalable fabrication techniques for portable PEC biosensing. Future prospects in the field are also discussed.

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Sensitive and Cost‐Effective Tools in the Detection of Ovarian Cancer Biomarkers

Elhami,

Mobed,

Soleimany

et al. 2024

Analytical Science Advances

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Women diagnosed with late‐stage ovarian cancer suffer a very high rate of mortality. Accordingly, it is imperative to detect and diagnose the disease as early as possible in its development. Achievement of this aim implies relatively large‐scale screening of women at an age of clinical significance through assay of biomarkers for disease present in blood or serum. Biosensor detection offers an attractive technology for the automated detection of such species. Among several biomarkers that have been identified that are present in patients with ovarian cancer, the only one that is commonly tested for in clinical use is cancer antigen 125, which is considered to be a poor biomarker for the disease. Here, we describe several biosensors that developed in the past decade for the detection of ovarian cancer biomarkers such as CA125, human epididymis protein 4 (HE4) and apolipoprotein A1. The challenges presented by the fabrication of biosensor devices for detecting ovarian cancer and the limited number of biosensors developed for this purpose are discussed.

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Biosensors; noninvasive method in detection of C-reactive protein (CRP)

Cited by 10 publications

References 47 publications

Improving Sensitivity and Reproducibility of Surface-Enhanced Raman Scattering Biochips Utilizing Magnetoplasmonic Nanoparticles and Statistical Methods

Improving Sensitivity and Reproducibility of Surface-Enhanced Raman Scattering Biochips Utilizing Magnetoplasmonic Nanoparticles and Statistical Methods

Recent advances on portable photoelectrochemical biosensors for diagnostics

Sensitive and Cost‐Effective Tools in the Detection of Ovarian Cancer Biomarkers

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