Biosorption von polycyclischen aromatischen Kohlenwasserstoffen an Mikroorganismen und Zellmembranen

Herrenbauer, Michael; Posten, Clemens

doi:10.1002/1522-2640(200009)72:9<1107::aid-cite11072>3.0.co;2-v

Cited by 2 publications

(7 citation statements)

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“…Thus, pyrenes in the fluid phase prefer to position themselves quite near the glycerol region of the bilayer. These results are in good agreement with previous simulation studies of pyrene in a lipid membrane 20 and with experimental measurements where pyrenes were mostly found between carbons C5 and C6 . The fact that pyrenes reside in the acyl chain region instead of the membrane center implies that intermolecular forces are playing a more important role than entropy.…”

Section: Resultssupporting

confidence: 92%

“…The study of Hoff et al proposed that free pyrene probes prefer to be positioned in the hydrophobic part of a membrane near the head group region, with the long axis of the probe being approximately in parallel to the bilayer normal . Other experimental studies based on fluorescent quenching support this view …”

Section: Introductionmentioning

confidence: 98%

“…The location of pyrene and its properties within a membrane have been characterized experimentally in a number of studies. ,,,− Fluorescence decay measurements of pyrene in fluid dipalmitoylphosphatidylcholine (DPPC) vesicles at different temperatures and concentrations have provided information about the excimer lifetimes, which have turned out to be on a scale of nanoseconds. , References 22 and 24 also considered the lateral diffusion of pyrene and have later been complemented by fluorescence self-quenching measurements in dimyristoylphosphatidylcholine (DMPC) vesicles . When it comes to pyrene-induced membrane perturbations, differential scanning calorimetry applied to DMPC vesicles has shown that pyrene causes a detectable reduction of the main phase transition temperature, T M .…”

Section: Introductionmentioning

confidence: 99%

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Free Pyrene Probes in Gel and Fluid Membranes: Perspective through Atomistic Simulations

et al. 2007

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We consider the properties of free pyrene probes inside gel- and fluidlike phospholipid membranes and unravel their influence on membrane properties. For this purpose, we employ atomic-scale molecular dynamics simulations at several temperatures for varying pyrene concentrations. Molecular dynamics simulations show that free pyrene molecules prefer to be located in the hydrophobic acyl chain region close to the glycerol group of lipid molecules. Their orientation is shown to depend on the phase of the membrane. In the fluid phase, pyrenes favor orientations where they are standing upright in parallel to the membrane normal, while, in the gel phase, the orientation is affected by the tilt of lipid acyl chains. Pyrenes are found to locally perturb membrane structure, while the nature of perturbations in the gel and fluid phases is completely different. In the gel phase, pyrenes break the local packing of lipids and decrease the ordering of lipid acyl chains around them, while, in the fluid phase, pyrenes increase the ordering of nearby acyl chains, thus having an opposite effect. Interestingly, this proposes a similarity to effects induced by cholesterol on structural membrane properties above and below the gel-fluid transition temperature. Further studies express a view that the orientational ordering of pyrene is not a particularly good measure of the acyl chain ordering of lipids. While pyrene ordering provides the correct qualitative behavior of acyl chain ordering in the fluid phase, its capability to predict the correct temperature dependence is limited.

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Free Pyrene Probes in Gel and Fluid Membranes: Perspective through Atomistic Simulations

et al. 2007

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“…They are more fat-soluble than water-soluble. It is to be expected that molecules of such (hazardous) substances enter the lipid phase of the tracheal membrane -independent of the function of the organ supplied by these tracheoles (Herrenbauer, 2002).…”

Section: Characterization Of Tracheoles and Potential Risk For Respirmentioning

confidence: 99%

“…Little is known about the special nature of the tracheole membrane and its contact to an adjacent or surrounding cell. a) PAH PAH molecules enter lipid membranes, accumulate in the region of the head groups of the lipid molecules (Herrenbauer, 2002), and possibly enter neighboring membranes. According to findings in Drosophila, however, membranes and cellular processes of insects react to these substances less than cellular processes of mammals (Würgler et al, 1986).…”

Section: Potential Fate and Effect Of Inhaled Hazardous Substances Inmentioning

confidence: 99%

Decline of Insects: Is Dust Emission Conflicting with Insects’ Tracheal System?

Thurm¹

2020

Preprint

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Is the extensive decline of insects partially due to an insect-specific feature of their functional organization that is disadvantageous for living in an industrialized environment? The unique way in which gases are supplied in insect tissues is such a special trait. It exposes cells directly to the gas phase, via tracheae that end in micro-tubes, the tracheoles, which have diameters in the same range as particles of ultra-fine dust transported by air of industrialized countries. Number and volume of these particles – calculated to be inhaled by honeybees, e.g., – are indicative to locally impede O2-uptake and CO2-release and thus to restrain physiological activities.

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Biosorption von polycyclischen aromatischen Kohlenwasserstoffen an Mikroorganismen und Zellmembranen

Cited by 2 publications

References 0 publications

Free Pyrene Probes in Gel and Fluid Membranes: Perspective through Atomistic Simulations

Free Pyrene Probes in Gel and Fluid Membranes: Perspective through Atomistic Simulations

Decline of Insects: Is Dust Emission Conflicting with Insects’ Tracheal System?

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